Association between tumor necrosis factor alpha-238G/a polymorphism and tuberculosis susceptibility: a meta-analysis study

BMC Infectious Diseases

Yang Wang³  Qin Liu¹  Lei Xun¹  Fan Zhang¹  Siying Meng²  Xudi Pu¹  Hang Zhu¹  Zhijiao Zhang¹ 

[1] School of Public Health and Health Management, Chongqing Medical University, Chongqing 400016, China;School of Foreign Language, Chongqing Medical University, Chongqing 400016, China;School of Public Health, Chongqing Medical University, No 1 Yixueyuan Road, Chongqing 400016, P.R. China

关键词: Meta-analysis;    Susceptibility;    Tuberculosis;    Polymorphism;    TNF-α;   

Others  :  1158770
DOI  :  10.1186/1471-2334-12-328

 received in 2012-04-22, accepted in 2012-11-26,  发布年份 2012

【 摘 要 】

Background

Tumor necrosis factor alpha (TNF-α) plays a key role in the containment of tuberculosis. The relationship between the TNF -238G/A polymorphism and tuberculosis susceptibility remains inconclusive. A comprehensive meta-analysis was made to provide a more precise estimate of the relationship between them.

Methods

Multiple search strategies were used. A fixed effect model was takentook to estimate pooled OR with 95% confidence interval (CI) for the association between the TNF -238G/A polymorphism and tuberculosis susceptibility. The Chi-squared-based Q-test and I-squaredI² statistic were calculated to examine heterogeneity. Begg’s funnel plot and Egger’s test were used to assess publication bias.

Results

9 case-control studies were included in this meta-analysis. No significant heterogeneity was demonstrated, and no obvious publication bias was detected among the included studies. The meta-analysis indicated that there was no significant association between the TNF -238G/A polymorphism and tuberculosis susceptibility (GA+AA versus GG model: OR=1.005, 95% CI: 0.765-1.319; A versus G model: OR=1.000, 95% CI: 0.769-1.300). In the subgroup analyses by ethnicity, types of TB and human immunodeficiency virus (HIV) status, no significant association were identified.

Conclusions

The meta-analysis involving 2723 subjects did not detect any association between the TNF -238G/A polymorphism and tuberculosis susceptibility.

【 授权许可】

   
2012 Zhang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

Figure 4.

Figure 5.

【 参考文献 】

• [1]World Health Organization: The burden of disease caused by TB Global tuberculosis control. 2011, 9-27.
• [2]World Health Organization: [http://www.who.int/mediacentre/factsheets/fs104/en/index.html] webciteTuberculosis.
• [3]Schurr E: Is susceptibility to tuberculosis acquired or inherited? J Intern Med 2007, 261:106-111.
• [4]Lewis SJ, Baker I, Davey Smith G: Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease 2005, 9:1174-1177.
• [5]Denholm JT, McBryde ES, Eisen DP: Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis. Clin Exp Immunol 2010, 162:84-90.
• [6]Can T, Yonglang Z, Jie Z, et al.: The +874T/A polymorphism in the interferon-gamma gene and tuberculosis risk: An update by meta-analysis. Hum Immunol 2011, 72:1137-1142.
• [7]Moeller M, Hoal EG: Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis. Tuberculosis (Amsterdam) 2010, 90:71-83.
• [8]Engele M, Stoessel E, Castiglione K, et al.: Induction of TNF in human alveolar macrophages as a potential evasion mechanism of virulent Mycobacterium tuberculosis. J Immunol 2002, 168:1328-1337.
• [9]Mohan VP, Scanga CA, Yu K, et al.: Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: Possible role for limiting pathology. Infect Immun 2001, 69:1847-1855.
• [10]Keane J, Gershon S, Wise RP, et al.: Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 2001, 345:1098-1104.
• [11]Messer G, Spengler U, Jung MC, et al.: Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med 1991, 173:209-219.
• [12]Aguillon JC, Cruzat A, Aravena O, et al.: Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution? Immunobiology 2006, 211:75-84.
• [13]Merza M, Farnia P, Anoosheh S, et al.: The NRAMPI, VDR and TNF-alpha Gene Polymorphisms in Iranian Tuberculosis Patients: The Study on Host Susceptibility. Braz J Infect Dis 2009, 13:252-256.
• [14]Sharma S, Rathored J, Ghosh B, et al.: Genetic polymorphisms in TNF genes and tuberculosis in North Indians. BMC Infect Dis 2010, 10:165. BioMed Central Full Text
• [15]Bayley JP, Ottenhoff THM, Verweij CL: Is there a future for TNF promoter polymorphisms? Genes Immun 2004, 5:315-329.
• [16]Correa PA, Gomez LM, Cadena J, et al.: Autoimmunity and tuberculosis. Opposite association with TNF polymorphism. J Rheumatol 2005, 32:219-224.
• [17]Amirzargar AA, Rezaei N, Jabbari H, et al.: Cytokine single nucleotide polymorphisms in Iranian patients with pulmonary tuberculosis. Eur Cytokine Netw 2006, 17:84-89.
• [18]Selvaraj P, Sriram U, Mathan Kurian S, et al.: Tumour necrosis factor alpha (-238 and -308) and beta gene polymorphisms in pulmonary tuberculosis: haplotype analysis with HLA-A, B and DR genes. Tuberculosis 2001, 81:335-341.
• [19]Fitness J, Floyd S, David K, et al.: Large-scale candidate gene study of tuberculosis susceptiblity in the karonga district of northern malawi. AmJTrop Med Hyg 2004, 71:341-349.
• [20]Vejbaesya S, Chierakul N, Luangtrakool P, et al.: NRAMP1 and TNF-alpha polymorphisms and susceptibility to tuberculosis in Thais. Respirology 2007, 12:202-206.
• [21]Ates Ö, Musellim B, Ongen G, et al.: Interleukin-10 and Tumor Necrosis Factor-α Gene Polymorphisms in Tuberculosis. J Clin Immunol 2008, 28:232-236.
• [22]G. Cochran W: The combination of estimates from different experiments. Biometrics 1954, 10:101-129.
• [23]Higgins JPT, Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med 2002, 21:1539-1558.
• [24]Mantel N, Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959, 22:719-748.
• [25]DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials 1986, 7:177-188.
• [26]Begg CB, Mazumdar M: Operating characteristics of a rank correlation test for publication bias. Biometrics 1994, 50:1088-1101.
• [27]Egger M, Davey Smith G, Schneider M, et al.: Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical research ed) 1997, 315:629-634.
• [28]M R, F R: GENEPOP (version 1.2): population genetics software for exact tests and ecumenicism. J Heredity 1995, 86:248-249.
• [29]Rousset F: Genepop’007: a complete reimplementation of the Genepop software for Windows and Linux. Mol Ecol Resources 2008, 8:103-106.
• [30]Chunmei J, Anya C, Jun L, et al.: Relationship of tumor necrosis factor alpha and beta genetic polymorphisms with onset of pulmonary tuberculosis in Hans of north China: A 1:1 paired case-control study. Chinses Journal of Clinical Rehabilitation 2006, 10:4.
• [31]Fan H, Wang Z, Feng F, et al.: Association of TNF-α-238G/A and 308 G/A Gene Polymorphisms with Pulmonary Tuberculosis among Patients with Coal Worker’s Pneumoconiosis. Biomed Environ Sci 2010, 23:137-145.
• [32]Zhaohai L: Association between Cytokine gene polymorphisms and pulmonary tuberculosis. Nanchang University, immunology; 2009. PhD thesis
• [33]Trajkov D, Trajchevska M, Arsov T, et al.: Association of 22 cytokine gene polymorphisms with tuberculosis in Macedonians. Indian J Tuberc 2009, 56:117-131.
• [34]Anoosheh S, Farnia P, Kargar M: Association between TNF-Alpha (-857) Gene Polymorphism and Susceptibility to Tuberculosis. Iranian Red Crescent Medical Journal 2010, 13:243-248.
• [35]Chunyan L, Yufang Y, Jufei F, et al.: Association between Bone-joint tuberculosis and TNF-α polymorphism. Chinese Journal of Spine and Spinal Cord 2011, 21:427-429.
• [36]Khoury MJ, Yang Q: The future of genetic studies of complex human diseases: an epidemiologic perspective. Epidemiology (Cambridge, Mass) 1998, 9:350-354.
• [37]Tsantes AE, Nikolopoulos GK, Bagos PG, et al.: Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: A meta-analysis. Int J Cardiol 2007, 118:189-196.
• [38]Qin W, Ping Z, Lixin Q, et al.: TNF-308 gene polymorphism and tuberculosis susceptibility: a meta-analysis involving 18 studies. Mol Biol Rep 2012, 39:3393-3400.
• [39]Gerard C, Bruyns C, Marchant A, et al.: Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993, 177:547-550.