The use of dietary supplements and their association with blood pressure in a large Midwestern cohort

BMC Complementary and Alternative Medicine

Richard A Dart²  Carla M Rottscheit²  Richard L Berg²  Catherine A McCarty¹ 

[1] Essentia Institute of Rural Health, 6AV-2 502 East Second Street, Duluth, MN 55805, USA;Marshfield Clinic Research Foundation, Marshfield, WI, USA

关键词: Dietary supplements;    Blood pressure;   

Others  :  1220478
DOI  :  10.1186/1472-6882-13-339

 received in 2013-04-24, accepted in 2013-11-12,  发布年份 2013

【 摘 要 】

Background

There have been numerous studies assessing the association of diet and blood pressure but little is known about the association between less commonly used nutritional supplements and blood pressured. The purpose of this study was to quantify the use of dietary supplements and their potential association with blood pressure in a large population-based cohort of adults in the Midwest.

Methods

The Personalized Medicine Research Project cohort was the population source for the current study. The current study includes subjects with Dietary History Questionnaire (DHQ) data available as well as at least one clinical blood pressure measurement recorded in their electronic medical record. After excluding extreme outlying measurements, median systolic and diastolic blood pressure measurements were calculated for each individual and were compared for subjects who did and did not report taking one of a list of 37 different supplements listed on the DHQ more than once per week over the previous 12 months.

Results

9,732 subjects had both blood pressure and DHQ data available. They ranged in age from 18 to 98 years (mean 56 years) and 3,625 (37%) were male. Nine of 37 supplements showed evidence for association with blood pressure: coenzyme Q10, fish oil, iron, bilberry, echinacea, evening primrose oil, garlic, goldenseal and milk thistle. With the exception of the mineral iron, mean systolic and diastolic blood pressures were higher for users of the specific supplements than non-users.

Conclusions

These results should not be interpreted as causal, nor can the direction of the association be assumed to be correct because the temporality of the association is unknown. We hope the observed significant associations will foster future research to evaluate blood pressure effects of dietary supplements.

【 授权许可】

   
2013 McCarty et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, et al.: Heart disease and stroke statistics – 2012 update: a report from the American Heart Association. Circulation 2012, 125:e2-e220.
• [2]Bartsch JA, Teare GF, Neufeld A, Hudema N, Muhajarine N: Secondary prevention of stroke in Saskatchewan, Canada: hypertension control. Int J Stroke 2012. doi: 10.1111/j.1747-4949.2012.00930.x. [Epub ahead of print]
• [3]Gillespie C, Kuklina EV, Briss PA, Blair NA, Hong Y: Vital signs: prevalence, treatment and control of hypertension – United States, 1999–2002 and 2005–2008. MMWR 2011, 60:103-108.
• [4]US Department of Health and Human Services: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. US Department of Health and Human Services; 2004. NIH Publication No. 04–5230 http://www.nhlbi.nih.gov/guidelines/hypertension/ webcite
• [5]Rasmussen CB, Glisson JK, Minor DS: Dietary supplements and hypertension: potential benefits and precautions. J Clin Hypertens 2012, 14:467-471.
• [6]McCarty CA, Wilke RA, Giampietro PF, Wesbrook S, Caldwell MD: Marshfield Clinic Personalized Medicine Research Project (PMRP): design, methods and recruitment for a large, population-based biobank. Pers Med 2005, 2:49-79.
• [7]Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, McNutt S, et al.: Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires. The eating at America’s table study. Am J Epidemiol 2001, 154:1089-1099.
• [8]Strobush L, Berg R, Cross D, Foth W, Kitchner T, Coleman L, McCarty CA: Dietary intake in the personalized medicine research project: a resource for studies of gene-diet interaction. Nutr J 2011, 10:13. BioMed Central Full Text
• [9]Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong J-Y, Watts GF: Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens 2007, 21:297-306.
• [10]Shah SA, Schlesselman L, Cios D, Lipeika J, Patel AA, Kluger J, White CM: Effects of Echinacea on electrocardiographic and blood pressure measurements. Am J Health Syst Pharm 2007, 64:1615-1618.
• [11]Brankovic S, Radenkovic M, Kitic D, Veljkovic S, Ivetic V, Pavlovic D, Miladinovic B: Comparison of the hypotensive and bradycardic activity of ginkgo, garlic, and onion extracts. Clin Experiment Hypertens 2011, 33:95-99.
• [12]Shim SH, Kim JM, Choi CY, Kim CY, Park KH: Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma. J Medicinal Food 2012, 15:818-823.
• [13]Buettner C, Yeh GY, Phillips RS, Mittleman MA, Kapthuk TJ: Systematic review of the effects of ginseng on cardiovascular risk factors. Ann Pharmacother 2005, 39:83-95.
• [14]Stavro PM, Woo M, Leiter LA, Heim TF, Sievenpiper JL, Vuksan V: Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function. Hypertension 2006, 47:791-796.
• [15]Simons S, Wollersheim H, Thien T: A systematic review on the influence of trial quality on the effect of garlic on blood pressure. Netherland J Med 2009, 67:212-219.
• [16]Stabler SN, Tejani AM, Hunyh F, Fowkes C: Garlic for the prevention of cardiovascular morbidity and mortality in hypertensive patients. Cochrane Database Syst Rev 2012., 810.1002/14651858.CD007653.pub2. CD007653
• [17]Appel LJ, Miller ER III, Seidler AJ, Whelton PK: Does supplementation of diet with ‘fish oil’ reduce blood pressure? A meta-analysis of controlled clinical trials. Arch Intern Med 1993, 153:1429-1438.
• [18]Morris MC, Sacks F, Rosner B: Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 1993, 88:523-533.
• [19]Xun P, Hou N, Liu K, Morris JS, Shikany JM, et al.: Fish oil, selenium and mercury in relation to incidence of hypertension: a 20-year follow-up study. J Internal Med 2011, 270:175-186.
• [20]Ueshima H, Stamler J, Elliott P, Chan Q, Brown IJ, Carnethon MR, et al.: Food omega-3 fatty acid intake of individuals (total, linoleic acid, long-chain) and their blood pressure. INTERMAP Study. Hypertension 2007, 50:131-319.
• [21]Nordmann AJ, Suter-Zimmerman K, Bucher HC, Shai I, Tuttle KR, Estruch R, et al.: Meta-analysis comparing Mediterranean to low-fat diets for modification of cardiovascular risk factors. Am J Med 2011, 124:841-851.
• [22]Tzoulaki I, Brown IJ, Chan Q, Van Horn L, Ueshima H, Zhao L, et al.: Realtion of iron and red meat intake to blood pressure: cross sectional epidemiological study. BMJ 2008, 337:a258.
• [23]Galan P, Vergnaud A-C, Tzoulaki I, Buyck J-F, Blacher J, Czernichow S, et al.: Low total and nonheme iron intakes are associated with a greater risk of hypertension. J Nutr 2010, 140:75-80.
• [24]Tzoulaki I, Patel CJ, Okamura T, Chan Q, Brown IJ, Miura K, et al.: A nutrient-wide association study on blood pressure. Circulation 2012, 126:2456-2464.