Study protocol for a randomised controlled trial of a cognitive-behavioural prevention programme for the children of parents with depression: the PRODO trial

BMC Psychiatry

Gerd Schulte-Körne²  Frans Oort¹  Kathrin Krick²  Kathrin Pietsch²  Belinda Platt² 

[1] Research Institute of Child Development and Education, Faculty of Social and Behavioural Sciences, University of Amsterdam, Nieuwe Achtergracht 127, Amsterdam, 1018, WS, Netherlands;Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-University, Nußbaumstraße 5a, Munich, 80336, Germany

关键词: Preventive;    SPIRIT;    Offspring;    RCT;    Parental depression;    Cognitive behavioural therapy;    Psychiatry;    Adolescent;    Paediatric;   

Others  :  1123331
DOI  :  10.1186/s12888-014-0263-2

 received in 2014-08-29, accepted in 2014-09-09,  发布年份 2014

【 摘 要 】

Background

Depression is one of the most common psychiatric illnesses worldwide, but is nevertheless preventable. Since the children of parents who have depression are at greatest risk of developing depression themselves, prevention programmes for this population are a major public health priority. Here we report the study protocol of a randomised controlled trial of a group-based psychological intervention for families with i) at least one parent who suffers (or has suffered) from depression and ii) at least one child who has no current or previous psychiatric diagnosis.

Methods/Design

Eligible families will be randomly allocated to receive either a German adaptation of the 12-session cognitive-behavioural Raising Healthy Children intervention (Gesund und glücklich aufwachsen; N = 50), or no intervention (usual care; N = 50). The primary outcome (child diagnosis of an episode of depression) will be assessed at 15-month follow-up. The secondary outcomes (child psychopathological symptoms) will be assessed immediately following completion of the intervention (6-months), as well as at 9- and 15-month follow-up. We hypothesise that children in the intervention condition, compared with those who do not receive the intervention, will show fewer symptoms of psychopathology, and be less likely to meet diagnostic criteria for a depressive episode, at follow-up.

Discussion

Despite their elevated risk of developing depression, there is little formal support available for the children of parents with depression. This study provides an important step in the development of more effective depression prevention measures, which are needed if the personal, social and economic burden of depression is to be reduced.

Trial registration

Clinical Trials NCT02115880 webcite. Registered April 7 2014.

【 授权许可】

   
2014 Platt et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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