Prevention of allergic airway hyperresponsiveness and remodeling in mice by Astragaliradix Antiasthmatic decoction

BMC Complementary and Alternative Medicine

Hua-Hao Shen¹  Wen Li²  Zhi-Hua Chen²  Li-Xia Xia²  Wen Hua²  Lan-Hong Zhang²  Bao-Ping Tian²  Su Xu² 

[1] State Key Laboratory of Respiratory Diseases, Guangzhou 510120, China;Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Medicine, 88 Jiefang Rd., Hangzhou 310009, China

关键词: Airway remodeling;    Airway hyperresponsiveness;    Astragalus Antiasthmatic Decoction;   

Others  :  1220417
DOI  :  10.1186/1472-6882-13-369

 received in 2013-05-13, accepted in 2013-11-29,  发布年份 2013

【 摘 要 】

Background

Astragali radix Antiasthmatic Decoction (AAD), a traditional Chinese medication, is found effective in treating allergic diseases and chronic cough. The purpose of this study is to determine whether this medication could suppress allergen-induced airway hyperresponsiveness (AHR) and remodeling in mice, and its possible mechanisms.

Methods

A mouse model of chronic asthma was used to investigate the effects of AAD on the airway lesions. Mice were sensitized and challenged with ovalbumin (OVA), and the extent of AHR and airway remodeling were characterized. Cells and cytokines in the bronchoalveolar lavage fluid (BALF) were examined.

Results

AAD treatment effectively decreased OVA-induced AHR, eosinophilic airway inflammation, and collagen deposition around the airway. It significantly reduced the levels of IL-13 and TGF-β1, but exerted inconsiderable effect on INF-γ and IL-10.

Conclusions

AAD greatly improves the symptoms of allergic airway remodeling probably through inhibition of Th2 cytokines and TGF-β1.

【 授权许可】

   
2013 Xu et al.; licensee BioMed Central Ltd.

【 图 表 】

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