Elite athletes’ genetic predisposition for altered risk of complex metabolic traits

BMC Genomics

Nir Eynon⁶  Ruth Birk³  Xu Yan⁶  Yuliya E Pushkareva⁴  Aleksandr V Degtyarev⁵  Evgeniy F Orekhov⁵  Dmitry A Dyatlov⁵  Agata Leońska-Duniec⁷  M-arek Sawczuk⁷  Agnieszka Maciejewska-Karlowska⁷  Aleksandra Zarebska¹  Pawel Cieszczyk⁷  Vladimir P Pushkarev⁵  Lauren K Banting² 

[1] Academy of Physical Education and Sport, Department of Sport Education, Gdansk, Poland;Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne 8001VICAustralia;Department of Nutrition, Faculty of Health Sciences, Ariel University, Ariel, Israel;South Ural State Medical University, Chelyabinsk, Russia;Ural State University of Physical Culture, Chelyabinsk, Russia;Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne, Australia;University of Szczecin, Department of Physical Culture and Health Promotion, Szczecin, Poland

Others  :  1109670
DOI  :  10.1186/s12864-014-1199-0

【 摘 要 】

BackgroundGenetic variants may predispose humans to elevated risk of common metabolic morbidities such as obesity and Type 2 Diabetes (T2D). Some of these variants have also been shown to influence elite athletic performance and the response to exercise training. We compared the genotype distribution of five genetic Single Nucleotide Polymorphisms (SNPs) known to be associated with obesity and obesity co-morbidities (IGF2BP2 rs4402960, LPL rs320, LPL rs328, KCJN rs5219, and MTHFR rs1801133) between athletes (all male, n?=?461; endurance athletes n?=?254, sprint/power athletes n?=?207), and controls (all male, n?=?544) in Polish and Russian samples. We also examined the association between these SNPs and the athletes? competition level (`elite? and `national? level). Genotypes were analysed by Single-Base Extension and Real-Time PCR. Multinomial logistic regression analyses were conducted to assess the association between genotypes and athletic status/competition level.Results IGF2BP2 rs4402960 and LPL rs320 were significantly associated with athletic status; sprint/power athletes were twice more likely to have the IGF2BP2 rs4402960 risk (T) allele compared to endurance athletes (OR?=?2.11, 95% CI =1.03-4.30, P <0.041), and non-athletic controls were significantly less likely to have the T allele compared to sprint/power athletes (OR =0.62, 95% CI =0.43-0.89, P <0.0009). The control group was significantly more likely to have the LPL rs320 risk (G) allele compared to endurance athletes (OR?=?1.26, 95% CI =1.05-1.52, P <0.013). Hence, endurance athletes were the ?protected? group being significantly (p?