Lavender oil suppresses indoleamine 2,3-dioxygenase activity in human PBMC

BMC Complementary and Alternative Medicine

Dietmar Fuchs³  Harald Schennach⁴  Florian Überall²  Sebastian Schroecksnadel³  Simon Geisler³  Kathrin Becker³  Markus Ganzera¹  Johanna M Gostner² 

[1] Institute of Pharmacy, Pharmacognosy, University of Innsbruck, Innsbruck, Austria;Division of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria;Division of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria;Central Institute of Blood Transfusion and Immunology, University Hospital, Innsbruck, Austria

关键词: Kynurenine;    Neopterin;    Indoleamine 2,3-dioxygenase;    Tryptophan;    Lavender oil;   

Others  :  1084623
DOI  :  10.1186/1472-6882-14-503

 received in 2014-01-10, accepted in 2014-12-09,  发布年份 2014

【 摘 要 】

Background

Lavender remedies have been used in traditional medicine because of antimicrobial, anti-inflammatory and mood alleviating effects, but underlying molecular mechanisms are not yet fully elucidated. Recently, studies investigating the effects of lavender oil in the context of psychiatric disorders have indicated potent pharmacological properties. Metabolism of tryptophan by indoleamine 2,3-dioxygenase (IDO) was found to provide a biochemical link between immunology and neuroendocrinology and to be a frequent target of natural products.

Methods

In this in vitro study, interferences of lavender oil and constituents (-)-linalool, (+)-α-pinene and (+)-limonene with tryptophan catabolism by IDO and formation of neopterin via guanosine triphosphate (GTP)-cyclohydrolase-I and of interferon-γ have been investigated using unstimulated and phytohemagglutinin (PHA)-stimulated human peripheral blood mononuclear cells (PBMC).

Results

Treatment with lavender oil dose-dependently suppressed PHA-induced tryptophan breakdown and kynurenine formation. Similar effects were observed for the three constituents. In parallel, formation of neopterin and interferon-γ was diminished upon lavender oil treatment. In unstimulated PBMC, effect of lavender oil treatment was similar, but less pronounced.

Conclusion

Data from this in vitro study suggest that lavender oil treatment might contribute to the modulation of the immune and neuroendocrine system by interfering with activation-induced tryptophan breakdown and IDO activity.

【 授权许可】

   
2014 Gostner et al.; licensee BioMed Central.

【 图 表 】

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