Diet, a new target to prevent depression?

BMC Medicine

Miguel A Martínez-González²  Almudena Sanchez-Villegas¹ 

[1] Deparment of Clinical Sciences, University of Las Palmas de Gran Canaria, PO Box 550, CP 35080, Las Palmas de Gran Canaria, Spain;Department of Preventive Medicine and Public Health, University of Navarra, C/Irunlarrea 1, CP 31008, Pamplona, Spain

关键词: primary prevention trial;    nutrigenetics;    trans fatty acids;    omega-3;    Mediterranean diet;    dietary patterns;    Cohort study;   

Others  :  857242
DOI  :  10.1186/1741-7015-11-3

 received in 2012-06-20, accepted in 2013-01-03,  发布年份 2013

【 摘 要 】

Background

Research on the role of diet in the prevention of depression is scarce. Some evidence suggests that depression shares common mechanisms with cardiovascular disease.

Discussion

Before considering the role of diet in the prevention of depression, several points need to be considered. First, in general, evidence has been found for the effects of isolated nutrients or foods, and not for dietary patterns. Second, most previous studies have a cross-sectional design. Third, information is generally collected though questionnaires, increasing the risk of misclassification bias. Fourth, adequate control of confounding factors in observational studies is mandatory.

Summary

Only a few cohort studies have analyzed the relationship between overall dietary patterns, such as the Mediterranean diet, and primary prevention of depression. They have found similar results to those obtained for the role of this dietary pattern in cardiovascular disease. To confirm the findings obtained in these initial cohort studies, we need further observational longitudinal studies with improved methodology, as well as large randomized primary prevention trials, with interventions based on changes in the overall food pattern, that include participants at high risk of mental disorders.

【 授权许可】

   
2013 Sanchez-Villegas and Martínez-González; licensee BioMed Central Ltd.

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