BMC Complementary and Alternative Medicine | |
Anti-hyperglycemic effects of three medicinal plants in diabetic pregnancy: modulation of T cell proliferation | |
Naim A Khan2  Kabirou Moutairou3  Mansourou Moudachirou4  Zouhair Tabka5  Anne-Marie Simonin2  Aziz Hichami1  Oussama Grissa5  Joachim Gbenou4  Akadiri Yessoufou3  | |
[1] INSERM U866, University of Bourgogne, 6 BD Gabriel, Dijon, 21000, France;University of Bourgogne, Physiology of Nutrition and Toxicology, INSERM UMR866, AgroSup/UB, Faculty of Life Sciences, 6 Boulevard Gabriel, Dijon, 21000, France;Laboratory of Cell Biology and Physiology, Department of Biochemistry and Cellular Biology, Faculty of Sciences and Techniques (FAST) and Institute of Applied Biomedical Sciences (ISBA), University of Abomey-Calavi, Cotonou, 01 BP 918, Benin;Laboratory of Pharmacognosy and Essential Oils (ISBA/FAST), University of Abomey-Calavi, Cotonou, 01 BP 918, Benin;Department of Physiology and Functional Exploration, University Hospital Farhat Hached, Sousse, 4000, Tunisia | |
关键词: Fatty acids; T-cell proliferation; Antioxidants; Diabetic pregnancy; Medicinal plants; | |
Others : 1230115 DOI : 10.1186/1472-6882-13-77 |
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received in 2012-05-26, accepted in 2013-03-26, 发布年份 2013 | |
【 摘 要 】
Background
Populations in Africa mostly rely on herbal concoctions for their primarily health care, but so far scientific studies supporting the use of plants in traditional medicine remain poor. The present study was undertaken to evaluate the anti-hyperglycemic effects of Picralima nitida (seeds), Nauclea latifolia (root and stem) and Oxytenanthera abyssinica (leaves) commonly used, in diabetic pregnancy.
Methods
Pregnant wistar rats, rendered diabetic by multiple low injections of streptozotocin, were treated with selected plant extracts based on their antioxidant activities. Vitamin C concentrations, fatty acid compositions and phytochemical analysis of plants extracts were determined. Effect of selected plant extracts on human T cell proliferation was also analysed.
Results
All analysed plant extracts exhibited substantial antioxidant activities probably related to their content in polyphenols. Picralima nitida exhibited the highest antioxidant capacity. Ethanolic and butanolic extracts of Picralima nitida, butanolic extract of Nauclea latifolia and ethanolic extract of Oxytenanthera abyssinica significantly decreased hyperglycemia in the diabetic pregnant rats. Butanolic extract of Picralima, also appeared to be the most potent immunosuppressor although all of the analysed extracts exerted an immunosuppressive effect on T cell proliferation probably due to their linolenic acid (C18:3n-3) and/or alkaloids content. Nevertheless, all analysed plants seemed to be good source of saturated and monounsaturated fatty acids.
Conclusion
By having antioxidant, anti-hyperglycemic and immunosuppressive activities, these plants could be good candidates in the treatment of diabetes and diabetic pregnancy.
【 授权许可】
2013 Yessoufou et al.; licensee BioMed Central Ltd.
【 预 览 】
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20151103112655713.pdf | 1867KB | download | |
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Figure 2. | 42KB | Image | download |
Figure 1. | 93KB | Image | download |
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