Rubella seroprevalence among pregnant women in Burkina Faso

BMC Infectious Diseases

Jean B Ouedraogo³  Claude P Muller²  Jacques R Kremer²  Emilie Charpentier²  Da Ernest¹  Zekiba Tarnagda³  Judith M Hübschen²  Marc C Tahita³ 

[1] Clinique Lorentia, Ministère de la Santé, Bobo-Dioulasso, 01 BP 502, Burkina Faso;Institute of Immunology, Centre de Recherche Public de la Santé/Laboratoire National de Santé, 20A rue Auguste Lumière, Luxembourg, L, 1950, Luxembourg;Institut de Recherche en Sciences de la Santé, 399 Avenue de la liberté, Bobo-Dioulasso, BP 545, Burkina Faso

关键词: Burkina Faso;    IgG;    Seroprevalence;    Rubella;   

Others  :  1149037
DOI  :  10.1186/1471-2334-13-164

 received in 2012-12-17, accepted in 2013-03-26,  发布年份 2013

【 摘 要 】

Background

Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso.

Methods

Between December 2007 and March 2008 serum samples were collected from 341 pregnant women in Bobo (n = 132, urban area) and Houndé (n = 209, rural area) and were tested for rubella-specific IgG antibodies with a commercial ELISA kit.

Results

An overall seropositivity rate of 95.0% (324/341) was found, with a higher percentage in the urban population and in the oldest age group. Considering an antibody titer of at least 10 International Units per ml as protective, the overall immunity rate in the cohort of pregnant women was 93.3% (318/341).

Conclusions

The high overall seropositivity rate in the absence of routine immunization suggests a continuous transmission of endemic rubella virus in Burkina Faso, posing a threat to non-immune pregnant women.

【 授权许可】

   
2013 Tahita et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Weir E, Sider D: A refresher on rubella. CMAJ 2005, 172(13):1680-1681.
• [2]De Santis M, Cavaliere AF, Straface G, Caruso A: Rubella infection in pregnancy. Reprod Toxicol 2006, 21(4):390-398.
• [3]Report of a Meeting on Preventing Congenital Rubella Syndrome: Immunization Strategies, Surveillance Needs. whqlibdoc.who.int/hq/2000/WHO_V&B_00.10_eng.pdf
• [4]Bamgboye AE, Afolabi KA, Esumeh FI, Enweani IB: Prevalence of rubella antibody in pregnant women in Ibadan, Nigeria. West Afr J Med 2004, 23(3):245-248.
• [5]Barreto J, Sacramento I, Robertson SE, Langa J, de Gourville E, Wolfson L, Schoub BD: Antenatal rubella serosurvey in Maputo, Mozambique. Trop Med Int Health 2006, 11(4):559-564.
• [6]Corcoran C, Hardie DR: Seroprevalence of rubella antibodies among antenatal patients in the Western Cape. S Afr Med J 2005, 95(9):688-690.
• [7]Dromigny JA, Nabeth P, Perrier Gros Claude JD: Evaluation of the seroprevalence of rubella in the region of Dakar (Senegal). Trop Med Int Health 2003, 8(8):740-743.
• [8]Faye-Kette YH, Sylla-Koko DJ, Akoua-Koffi GC, Kacou-N’Douba A, Cissel L, Bouzid S, Acho YB, N’Takpe BN, Dosso M: Seroprevalence of rubella in 461 pregnant women in Abidjan (Cote d’Ivoire). Bull Soc Pathol Exot 1993, 86(3):185-187.
• [9]Rodier MH, Berthonneau J, Bourgoin A, Giraudeau G, Agius G, Burucoa C, Hekpazo A, Jacquemin JL: Seroprevalences of Toxoplasma, malaria, rubella, cytomegalovirus, HIV and treponemal infections among pregnant women in Cotonou, Republic of Benin. Acta Trop 1995, 59(4):271-277.
• [10]Monjour L, Druilhe P, Huraux JM, Palminteri R, Froment A, Kyelem JM, Alfred C, Laplace JL, Gentilini M: Rubella epidemiology in rural Upper Volta. Acta Trop 1982, 39(3):247-252.
• [11]Linguissi LS, Nagalo BM, Bisseye C, Kagone TS, Sanou M, Tao I, Benao V, Simpore J, Kone B: Seroprevalence of toxoplasmosis and rubella in pregnant women attending antenatal private clinic at Ouagadougou, Burkina Faso. Asian Pac J Trop Med 2012, 5(10):810-813.
• [12]WHO: Rubella vaccines: WHO position paper. Wkly Epidemiol Rec 2011, 86(29):301-316.
• [13]Robertson SE, Featherstone DA, Gacic-Dobo M, Hersh BS: Rubella and congenital rubella syndrome: global update. Rev Panam Salud Publica 2003, 14(5):306-315.
• [14]The World Factbook. https://www.cia.gov/library/publications/the-world-factbook/geos/uv.html webcite
• [15]Vynnycky E, Gay NJ, Cutts FT: The predicted impact of private sector MMR vaccination on the burden of congenital rubella syndrome. Vaccine 2003, 21(21-22):2708-2719.