Insights into the miRNA regulations in human disease genes

BMC Genomics

Tapash Chandra Ghosh¹  Soumita Podder¹  Jyotirmoy Das¹ 

[1] Bioinformatics Centre, Bose Institute, P 1/12, C.I.T. Scheme VII M, Kolkata 700 054, India

关键词: Epigenetic modifications;    AREScores;    mRNA decay rates;    Cancer;    MicroRNAs;   

Others  :  1091513
DOI  :  10.1186/1471-2164-15-1010

 received in 2014-07-11, accepted in 2014-11-11,  发布年份 2014

【 摘 要 】

Background

MicroRNAs are a class of short non-coding RNAs derived from either cellular or viral transcripts that act post-transcriptionally to regulate mRNA stability and translation. In recent days, increasing numbers of miRNAs have been shown to be involved in the development and progression of a variety of diseases. We, therefore, intend to enumerate miRNA targets in several known disease classes to explore the degree of miRNA regulations on them which is unexplored till date.

Results

Here, we noticed that miRNA hits in cancer genes are remarkably higher than other diseases in human. Our observation suggests that UTRs and the transcript length of cancer related genes have a significant contribution in higher susceptibility to miRNA regulation. Moreover, gene duplication, mRNA stability, AREScores and evolutionary rate were likely to have implications for more miRNA targeting on cancer genes. Consequently, the regression analysis have confirmed that the AREScores plays most important role in detecting miRNA targets on disease genes. Interestingly, we observed that epigenetic modifications like CpG methylation and histone modification are less effective than miRNA regulations in controlling the gene expression of cancer genes.

Conclusions

The intrinsic properties of cancer genes studied here, for higher miRNA targeting will enhance the knowledge on cancer gene regulation.

【 授权许可】

   
2014 Das et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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