High-risk human papillomavirus infection is associated with premature rupture of membranes

BMC Pregnancy and Childbirth

HaiJoong Kim³  Min-Jeong Oh³  Jae-Kwan Lee³  Jin-Hwa Hong³  SuhngWook Kim²  Hye-Ri Hong¹  Kyung-Jin Min¹  GeumJoon Cho³ 

[1] Department of Obstetrics and Gynecology, Inha University Hospital, Incheon, Korea;Department of Biomedical Science, College of Health Sciences, Korea University, Seoul, Korea;Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea

关键词: Complication;    Pregnancy;    Human papillomavirus;   

Others  :  1137878
DOI  :  10.1186/1471-2393-13-173

 received in 2013-01-03, accepted in 2013-08-30,  发布年份 2013

【 摘 要 】

Background

Human papillomavirus (HPV) is known to be more prevalent in spontaneous abortions than in elective terminations of pregnancy. More recently, placental infection with HPV was shown to be associated with spontaneous preterm delivery. However, no study has evaluated the prevalence of HPV infection in pregnant Korean females and its association with adverse pregnancy outcomes.

Methods

We conducted a cross-sectional study of 311 females who gave birth at Korea University Medical Center. Our sample included 45 preterm deliveries, 50 cases of premature rupture of the membranes (PROM), 21 preeclampsia cases, and 8 gestational diabetes mellitus (GDM) patients. We used the Hybrid Capture II system to detect high-risk (HR)-HPV infection at six weeks postpartum.

Results

The prevalence of HR-HPV infection was 14.1%. Women with HR-HPV infection had a higher incidence of PROM than those without HR-HPV. HR-HPV infection was associated with an increased risk of PROM (OR, 2.380; 95% CI, 1.103-5.134). The prevalence of preterm delivery, preeclampsia, or GDM was not different between the two groups.

Conclusions

We observed a high prevalence of HR-HPV infection in pregnant women. Moreover, HR-HPV infection was associated with a risk of PROM at term. Further studies are needed to evaluate mechanisms by which HR-HPV infection induces PROM.

【 授权许可】

   
2013 Cho et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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