期刊论文详细信息
BMC Health Services Research
On the improvement of blood sample collection at clinical laboratories
Nuria Barba4  Imma Caballé4  Mauricio GC Resende2  Luciana S Pessoa3  Helena Ramalhinho1  Alex Grasas1 
[1] Barcelona GSE, Barcelona, Spain;AT&T Labs Research, Florham Park, NJ, USA;IN3 Universitat Oberta de Catalunya, c/ Roc Boronat, 117, 08018 Barcelona, Spain;Catlab, Barcelona, Spain
关键词: Operations research;    Genetic algorithm;    Vehicle routing problem;    Blood sample transportation;   
Others  :  1134347
DOI  :  10.1186/1472-6963-14-12
 received in 2013-04-19, accepted in 2013-11-14,  发布年份 2014
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【 摘 要 】

Background

Blood samples are usually collected daily from different collection points, such hospitals and health centers, and transported to a core laboratory for testing. This paper presents a project to improve the collection routes of two of the largest clinical laboratories in Spain. These routes must be designed in a cost-efficient manner while satisfying two important constraints: (i) two-hour time windows between collection and delivery, and (ii) vehicle capacity.

Methods

A heuristic method based on a genetic algorithm has been designed to solve the problem of blood sample collection. The user enters the following information for each collection point: postal address, average collecting time, and average demand (in thermal containers). After implementing the algorithm using C programming, this is run and, in few seconds, it obtains optimal (or near-optimal) collection routes that specify the collection sequence for each vehicle. Different scenarios using various types of vehicles have been considered. Unless new collection points are added or problem parameters are changed substantially, routes need to be designed only once.

Results

The two laboratories in this study previously planned routes manually for 43 and 74 collection points, respectively. These routes were covered by an external carrier company. With the implementation of this algorithm, the number of routes could be reduced from ten to seven in one laboratory and from twelve to nine in the other, which represents significant annual savings in transportation costs.

Conclusions

The algorithm presented can be easily implemented in other laboratories that face this type of problem, and it is particularly interesting and useful as the number of collection points increases. The method designs blood collection routes with reduced costs that meet the time and capacity constraints of the problem.

【 授权许可】

   
2014 Grasas et al.; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1]Rais A, Viana A: Operations research in healthcare: a survey. Int Trans Operat Res 2010, 18:1-31.
  • [2]Carraro P, Plebani M: Errors in a stat laboratory: types and frequencies 10 years later. Clin Chem 2007, 53:1338-1342.
  • [3]Da Rin G: Pre-analytical workstations: a tool for reducing laboratory errors. Clin Chim Acta 2009, 404:68-74.
  • [4]Becan-McBride K: Avoiding specimen transportation errors. Medical Laboratory Observer 2002, 34:38-39.
  • [5]Toth P, Vigo D: An overview of vehicle routing problems. In The vehicle routing problem. Edited by Toth P, Vigo D. Philadelphia: SIAM; 2002:1-26.
  • [6]Garey MR, Johnson DS: Computers and intractability: a guide to the theory of NP-completeness. San Francisco: W. H. Freeman & Co; 1979.
  • [7]Laporte G: Fifty years of vehicle routing. Transport Sci 2009, 43:408-416.
  • [8]Li FY, Golden B, Wasil E: The open vehicle routing problem: algorithms, large-scale test problems, and computational results. Comput Operat Res 2007, 34:2918-2930.
  • [9]Generalitat de Catalunya, Departament de Sanitat i Seguretat Social, Direcció general de recursos sanitaris: Requisitos del transporte de muestras de diagnóstico para garantizar la estabilidad de sus propiedades biológicas. 2003. [http://www.ifcc.org/ria/div/muestras.pdf webcite]
  • [10]Park J, Kim BI: The school bus routing problem: a review. Eur J Operat Re 2010, 202:311-319.
  • [11]Belles-Sampera B, Ventura-Pedretb S, Gomis-Castellvi M, March-Amengualc JM: Rutas de recogida de muestras y error en el proceso analítico. Revista del Laboratorio Clínico 2012, 5:10-17.
  • [12]Gendreau M, Potvin JY (Eds): Handbook of Metaheuristics. 2nd edition. New York: Springer; 2010.
  • [13]Holland J: Genetic algorithms and the optimal allocation of trials. SIAM Journal on Computing 1972, 2:88-105.
  • [14]Bean JC: Genetic algorithms and random keys for sequencing and optimization. ORSA Journal on Computing 1994, 6:154-160.
  • [15]Gonçalves JF, Resende MGC: Biased random-key genetic algorithms for combinatorial optimization. Journal of Heuristics 2011, 17:487-525.
  • [16]Spears WM, DeJong KA: On the virtues of parameterized uniform crossover. In Proceedings of the Fourth International Conference on Genetic Algorithms. San Diego, CA: Morgan Kaufmann; 1991:230-236.
  • [17]ILOG CPLEX User’s Manual. http://www-03.ibm.com/software/products/en/ibmilogcpleoptistud/ webcite
  • [18]Brandeau ML, Sainfort F, Pierskalla WP (Eds): Operations research and health care: a handbook of methods and applications. New York: Kluwer Academic Publishers; 2004.
  • [19]Romeijn HE, Zenios SA: Introduction to the special issue on operations research in health care. Oper Res 2008, 56:1333-1334.
  • [20]Alejo JS, Martin MG, Ortega-Mier M, Garcia-Sanchez A: Mixed integer programming model for optimizing the layout of an ICU vehicle. BMC Health Serv Res 2009, 9:224. BioMed Central Full Text
  • [21]Jun GT, Morris Z, Eldabi T, Harper P, Naseer A, Patel B, Clarkson JP: Development of modelling method selection tool for health services management: from problem structuring methods to modelling and simulation methods. BMC Health Serv Res 2011, 11:108. BioMed Central Full Text
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