Serum HMGB1 as a prognostic marker for malignant pleural mesothelioma

BMC Cancer

Chiharu Tabata¹  Eisuke Shibata¹  Rie Tabata³  Shingo Kanemura¹  Koji Mikami¹  Yoshitaka Nogi¹  Eriko Masachika¹  Tomoyuki Nishizaki²  Takashi Nakano¹ 

[1] Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

[2] Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

[3] Department of Internal Medicine, Hyogo Prefectural Tsukaguchi Hospital, Hyogo, Japan

关键词: HMGB1;    Tumor marker;    Mesothelioma;   

Others  :  1079786
DOI  :  10.1186/1471-2407-13-205

 received in 2012-12-09, accepted in 2013-04-18,  发布年份 2013

【 摘 要 】

Background

Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to conventional chemotherapy and radiotherapy. Therefore, diagnosing MPM early is very important. Some researchers have previously reported that high-mobility group box 1 (HMGB1) was correlated with pulmonary fibrosis. MPM involves the malignant transformation of mesothelial cells, which originate from mesenchymal cells similar to lung fibroblasts. Here, we investigated serum levels of HMGB1 in patients with MPM and compared them with those of a population that had been exposed to asbestos without developing MPM.

Methods

HMGB1 production from MPM cell lines was measured using ELISA. Serum HMGB1 levels were also examined in 61 MPM patients and 45 individuals with benign asbestos-related diseases.

Results

HMGB1 concentrations of 2 out of 4 MPM cell lines were higher than that of normal mesothelial cell line, Met-5A. We demonstrated that patients with MPM had significantly higher serum levels of HMGB1 than the population who had been exposed to asbestos but had not developed MPM. The difference in overall survival between groups with serum HMGB1 levels that were lower and higher than assumed cut-off values was significant.

Conclusions

Our data suggest that serum HMGB1 concentration is a useful prognostic factor for MPM.

【 授权许可】

   
2013 Tabata et al.; licensee BioMed Central Ltd.

【 图 表 】

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