The LIFE child study: a life course approach to disease and health

BMC Public Health

Wieland Kiess⁶  Antje Körner⁶  Andreas Hiemisch⁵  Matthew A Sabin³  Christiane Koch²  Stephanie Naumann²  Mandy Geserick²  Nora Casprzig²  Elena Sergeyev⁵  Christian Hirsch⁷  Michael Fuchs¹  Mirko Döhnert⁴  Mara Hesse⁵  Mirja Quante⁶ 

[1] Section of Phoniatrics and Audiology of the Department of Otorhinolaryngology, University of Leipzig, Liebigstrasse 10-14, D-04103 Leipzig, Germany;LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthalstrasse 27, D-04103 Leipzig, Germany;University of Melbourne, Melbourne, Melbourne, Victoria 3010, Australia;Department of Women and Child Health, Hospital for Child and Adolescent Psychiatry, University of Leipzig, Liebigstrasse 20a, D-04103 Leipzig, Germany;Department of Women and Child Health, Hospital for Children and Adolescents and Centre for Paediatric Research (CPL), University of Leipzig, Liebigstrasse 20a, D-04103 Leipzig, Germany;IFB Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Philipp-Rosenthalstrasse 27, D-04103 Leipzig, Germany;Department of Paediatric Dentistry, University of Leipzig, Nürnbergerstr. 57, D-04103 Leipzig, Germany

关键词: Epidemiology;    Life-course;    Pregnancy;    Children;    Cohort study;   

Others  :  1162787
DOI  :  10.1186/1471-2458-12-1021

 received in 2012-10-03, accepted in 2012-11-12,  发布年份 2012

【 摘 要 】

Background

Profound knowledge about child growth, development, health, and disease in contemporary children and adolescents is still rare. Epidemiological studies together with new powerful research technologies present exciting opportunities to the elucidation of risk factor-outcome associations with potentially major consequences for prevention, diagnosis and treatment.

Aim

To conduct a unique prospective longitudinal cohort study in order to assess how environmental, metabolic and genetic factors affect growth, development and health from fetal life to adulthood.

Methods

The ‘Leipzig Research Centre for Civilization Diseases (LIFE) Child Study’ focuses on two main research objectives: (1) monitoring of normal growth, development and health; (2) non-communicable diseases such as childhood obesity and its co-morbidities, atopy and mental health problems. Detailed assessments will be conducted alongside long-term storage of biological samples in 2,000 pregnant women and more than 10,000 children and their families.

Results

Close coordination and engagement of a multidisciplinary team in the LIFE Child study successfully established procedures and systems for balancing many competing study and ethical needs. Full participant recruitment and complete data collection started in July 2011. Early data indicate a high acceptance rate of the study program, successful recruitment strategies and the establishment of a representative cohort for the population of Leipzig. A series of subprojects are ongoing, and analyses and publications are on their way.

Discussion

This paper addresses key elements in the design and implementation of the new prospective longitudinal cohort study LIFE Child. Given the recognized need for long-term data on adverse effects on health and protective factors, our study data collection should provide magnificent opportunities to examine complex interactions that govern the emergence of non-communicable diseases.

【 授权许可】

   
2012 Quante et al.; licensee BioMed Central Ltd.

【 图 表 】

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