期刊论文详细信息
BMC Surgery
Pancreato-jejunostomy versus hand-sewn closure of the pancreatic stump to prevent pancreatic fistula after distal pancreatectomy: a retrospective analysis
Piero Chirletti1  Monica Schiratti1  Dario Borreca1  Roberto Caronna1  Roberto L Meniconi1 
[1] Department of Surgical Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy
关键词: Hand-sewn Closure;    Roux-en-Y;    Pancreato-jejunostomy;    Pancreatic Fistula;    Distal Pancreatectomy;   
Others  :  866918
DOI  :  10.1186/1471-2482-13-23
 received in 2012-09-16, accepted in 2013-06-28,  发布年份 2013
PDF
【 摘 要 】

Background

Different methods of pancreatic stump closure after distal pancreatectomy (DP) have been described to decrease the incidence of pancreatic fistula (PF) which still represents one of the most common complications in pancreatic surgery. We retrospectively compared the pancreato-jejunostomy technique with the hand-sewn closure of the pancreatic stump after DP, and analyzed clinical outcomes between the two groups, focusing on PF rate.

Methods

Thirty-six patients undergoing open DP at our institution between May 2005 and December 2011 were included. They were divided in two groups depending on pancreatic remnant management: in 24 cases the stump was closed by hand-sewn suture (Group A), while in 12 earlier cases a pancreato-jejunostomy was performed (Group B). We analyzed postoperative data in terms of mortality, morbidity and length of hospital stay between the two groups.

Results

PF occurred in 7 of 24 (29.1%) cases of group A (control group) compared to zero fistula rate in group B (anastomosis group) (p=0.005). Operative time was significantly higher in the anastomosis group (p=0.024). Mortality rate was 0% in both groups. Other postoperative outcomes such as hemorrhages, infections, medical complications and length of hospital stay were not significant between the two groups.

Conclusion

Despite a higher operative time, the pancreato-jejunostomy after DP seems to be related to a lower incidence of PF compared to the hand-sewn closure of the pancreatic remnant.

【 授权许可】

   
2013 Meniconi et al.; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20140728071204983.pdf 697KB PDF download
91KB Image download
122KB Image download
【 图 表 】

【 参考文献 】
  • [1]Lillemoe KD, Kaushal S, Cameron JL, Sohn TA, Pitt HA, Yeo CJ: Distal pancreatectomy: indications and outcomes in 235 patients. Ann Surg 1999, 229(5):693-698.
  • [2]Schnelldorfer T, Mauldin PD, Lewin DN, Adams DB: Distal pancreatectomy for chronic pancreatitis: risk factors for postoperative pancreatic fistula. J Gastrointest Surg 2007, 11(8):991-997.
  • [3]Rodriguez JR, Germes SS, Pandharipande PV, Gazelle GS, Thayer SP, Warshaw AL, Fernandez-del Castillo C: Implications and cost of pancreatic leak following distal pancreatic resection. Arch Surg 2006, 141(4):361-366.
  • [4]Adam U, Makowiec F, Riediger H, Benz S, Liebe S, Hopt UT: Pancreatic leakage after pancreas resection. An analysis of 345 operated patients. Chirurg 2002, 73(5):466-473.
  • [5]Sheehan MK, Beck K, Creech S, Pickleman J, Aranha GV: Distal pancreatectomy: does the method of closure influence fistula formation? Am Surg 2002, 68:264-267.
  • [6]Ferrone CR, Warshaw AL, Rattner DW, Berger D, Zheng H, Rawal B, Rodriguez R, Thayer SP, Fernandez-del Castillo C: Pancreatic fistula rates after 462 distal pancreatectomies. Stapler do not decrease fistula rates. J Gastrointest Surg 2008, 12:1691-1698.
  • [7]Diener MK, Seiler CM, Rossion I, Kleeff J, Glanemann M, Butturini G, Tomazic A, Bruns CJ, Busch OR, Farkas S, Belyaev O, Neoptolemos JP, Halloran C, Keck T, Niedergethmann M, Gellert K, Witzigmann H, Kollmar O, Langer P, Steger U, Neudecker J, Berrevoet F, Ganzera S, Heiss MM, Luntz SP, Bruckner T, Kieser M, Büchler MW: Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial. Lancet 2011, 377(9776):1514-1522.
  • [8]Konishi T, Hiraishi M, Kubota K, Bandai Y, Makuuchi M, Idezuki Y: Segmental occlusion of the pancreatic duct with prolamine to prevent fistula formation after distal pancreatectomy. Ann Surg 1995, 221(2):165-170.
  • [9]Ochiai T, Sonoyama T, Soga K, Inoue K, Ikoma H, Shiozaki A, Kuriu Y, Kubota T, Nakanishi M, Kikuchi S, Ichikawa D, Fujiwara H, Sakakura C, Okamoto K, Kokuba Y, Otsuji E: Application of polyethylene glycolic acid felt with fibrin sealant to prevent postoperative pancreatic fistula in pancreatic surgery. J Gastrointest Surg 2010, 14(5):884-890.
  • [10]Blansfield JA, Rapp MM, Chokshi RJ, Woll NL, Hunsinger MA, Sheldon DG, Shabahang MM: Novel method of stump closure for distal pancreatectomy with a 75% reduction in pancreatic fistula rate. J Gastrointest Surg 2012, 16(3):524-528.
  • [11]Kleeff J, Diener MK, Z’graggen K, Hinz U, Wagner M, Bachmann J, Zehetner J, Müller MW, Friess H, Büchler MW: Distal pancreatectomy: risk factors for surgical failure in 302 consecutive cases. Ann Surg 2007, 245(4):573-582.
  • [12]Adam U, Makowiec F, Riediger H, Trzeczak S, Benz S, Hopt UT: Distal pancreatic resection - indications, techniques and complications. Zentralbl Chir 2001, 126(11):908-912.
  • [13]Chirletti P, Peparini N, Caronna R, Fanello G, Delogu G, Meniconi RL: Roux-en-Y end-to-end and end-to-side double pancreaticojejunostomy: application of the reconstructive method of the Beger procedure to central pancreatectomy. Langenbecks Arch Surg 2010, 395(1):89-93.
  • [14]Wagner M, Gloor B, Ambuhl M, Worni M, Lutz JA, Angst E, Candinas D: Roux-en-Y drainage of the pancreatic stump decreases pancreatic fistula after distal pancreatic resection. J Gastrointest Surg 2007, 11(3):303-308.
  • [15]Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, Neoptolemos J, Sarr M, Traverso W, Buchler M: Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 2005, 138(1):8-13.
  • [16]Wente MN, Veit JA, Bassi C, Dervenis C, Fingerhut A, Gouma DJ, Izbicki JR, Neoptolemos JP, Padbury RT, Sarr MG, Yeo CJ, Büchler MW: Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery 2007, 142(1):20-25.
  • [17]Hashimoto Y, Traverso LW: Incidence of pancreatic anastomotic failure and delayed gastric emptying after pancreatoduodenectomy in 507 consecutive patients: use of a web-based calculator to improve homogeneity of definition. Surgery 2010, 147(4):503-515.
  • [18]Balcom JHIV, Rattner DW, Warshaw AL, Chang Y, Fernandez-del Castillo C: Ten year experience with 733 pancreatic resections: changing indications, older patients and decreasing length of hospitalization. Arch Surg 2001, 136:391-398.
  • [19]Hamanaka Y, Nishihara K, Hamasaki T, Kawabata A, Yamamoto S, Tsurumi M, Ueno T, Suzuki T: Pancreatic juice output after pancreatoduodenectomy in relation to pancreatic consistency, duct size, and leakage. Surgery 1996, 119(3):281-287.
  • [20]Yeo CJ, Cameron JL, Lillemoe KD, Sauter PK, Coleman J, Sohn TA, Campbell KA, Choti MA: Does prophylactic octreotide decrease the rates of pancreatic fistula and other complications after pancreaticoduodenectomy? Results of a prospective randomized placebo-controlled trial. Ann Surg 2000, 232(3):419-429.
  • [21]Lowy AM, Lee JE, Pisters PW, Davidson BS, Fenoglio CJ, Stanford P, Jinnah R, Evans DB: Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease. Ann Surg 1997, 226(5):632-641.
  • [22]Gurusamy KS, Koti R, Fusai G, Davidson BR: Somatostatin analogues for pancreatic surgery. Cochrane Database Syst Rev 2010., 2CD008370
  • [23]Buchler M, Friess H, Kelmpa I, Hermanek P, Sulkowski U, Becker H, Schafmayer A, Baca I, Lorenz D, Meister R: Role of octreotide in the prevention of postoperative complication following pancreatic resection. Am J Surg 1992, 163:125-131.
  • [24]Montorsi M, Zago M, Mosca F, Capussotti L, Zotti E, Ribotta G, Fegiz G, Fissi S, Roviaro G, Peracchia A: Efficacy of octreotide in the prevention of pancreatic fistula after elective pancreatic resections: a prospective, controlled, randomized trial. Surgery 1995, 117:26-31.
  • [25]Connor S, Alexakis N, Garden OJ, Leandros E, Bramis J, Wigmore SJ: Meta-analysis of the value of somatostatin and its analogues in reducing complications associated with pancreatic surgery. Br J Surg 2005, 92(9):1059-1067.
  • [26]Goh BK, Tan YM, Chung YF, Cheow PC, Ong HS, Chan WH, Chow PK, Soo KC, Wong WK, Ooi LL: Critical appraisal of 232 consecutive distal pancreatectomies with emphasis on risk factors, outcome, and management of the postoperative pancreatic fistula: a 21-year experience at a single institution. Arch Surg 2008, 143(10):956-965.
  文献评价指标  
  下载次数:49次 浏览次数:0次