Acute lymphoblastic leukemia in a 2-year-old girl whose mother was previously diagnosed with antiphospholipid syndrome: a case report

BMC Research Notes

Lucy Adela Tibaduiza-Buitrago²  Ernesto Rueda-Arenas¹  Carlos Efraín Cortés-Sánchez⁴  Miguel Ángel Castro-Jiménez³ 

[1] Departamento de Pediatría, Facultad de Salud. Universidad Industrial de Santander - Hospital Universitario de Santander, Carrera 33 No. 20-126., Bucaramanga, (Santander), Colombia;Grupo Colombiano de Estudios Alfa en Epidemiología, Salud Poblacional, Estadística Aplicada y Ciencias Aliadas. Magna Science Corporation, Bogotá, D.C., Colombia;Grupo de Investigación Epidemiológica del Cáncer, Instituto Nacional de Cancerología, Avenida Calle 1 No. 9-85, Bogotá, D.C., Colombia;Postgrado en Salud Ocupacional. Universidad El Bosque, Avenida Carrera 9 No. 131 A – 02, Edificio Fundadores, Bogotá, D.C., Colombia

关键词: Maternal exposure;    Antiphospholipid syndrome;    Case report;    Child;    Acute lymphoblastic leukemia;   

Others  :  1177909
DOI  :  10.1186/s13104-015-1104-1

 received in 2014-03-07, accepted in 2015-03-31,  发布年份 2015

【 摘 要 】

Background

The role of maternal exposures and conditions in the origin of childhood cancer has been a subject of growing interest, but current evidence is inconclusive.

Case presentation

We present a case detected in a multicenter case–control study evaluating the association between parental risk factors and childhood acute lymphoblastic leukemia (ALL). The patient is a Colombian girl who was diagnosed with ALL-L1 when she was 2 years old. Her mother had been diagnosed with antiphospholipid syndrome before pregnancy and had also been treated with subcutaneous injections of heparin. Other potentially relevant maternal and patient exposures are also reported in this paper.

Conclusion

We hypothesize that the maternal autoimmune disease could be a contributor in the causality network of the daughter’s leukemia. However, the role of other exposures cannot be excluded.

【 授权许可】

   
2015 Castro-Jiménez et al.; licensee BioMed Central.

【 参考文献 】

• [1]Castro-Jiménez MA, Orozco-Vargas LC: Parental exposure to carcinogens and risk for childhood acute lymphoblastic leukemia, Colombia, 2000–2005. Prev Chronic Dis 2011, 8(5):A106.
• [2]Castro-Jiménez MA: Exposiciones preconcepcionales y prenatales ¿están asociadas con leucemia linfoblástica aguda en los menores de 15 años?. Universidad Industrial de Santander, Bucaramanga; 2007.
• [3]Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. International Agency for Research on Cancer, Lyon, France; 2010.
• [4]Petridou E, Trichopoulos D: Leukemias. In Textbook of Cancer Epidemiology. Edited by Adami HO, Hunter D, Trichopoulos D. Oxford University Press, Oxford; 2002:556-8.
• [5]Fabia J, Thuy TD: Occupation of father at time of birth of children dying of malignant diseases. Br J Prev Soc Med 1974, 28(2):98-100.
• [6]Infante-Rivard C, Siemiatycki J, Lakhani R, Nadon L: Maternal Exposure to Occupational Solvents and Childhood Leukemia. Environ Health Perspect 2005, 113:787-92.
• [7]McKinney PA, Fear NT, Stockton D: On behalf of the UK childhood cancer study investigators: Parental occupation at periconception: findings from the United Kingdom Childhood Cancer Study. Occup Environ Med 2003, 60:901-9.
• [8]Jensen CD, Block G, Buffler P, Ma X, Selvin S, Month S: Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States). Cancer Causes Control 2004, 15:559-70.
• [9]Milne E, Greenop KR, Scott RJ, Bailey HD, Attia J, Dalla-Pozza L, et al.: Parental prenatal smoking and risk of childhood acute lymphoblastic leukemia. Am J Epidemiol 2012, 175(1):43-53.
• [10]Glass DC, Reid A, Bailey HD, Milne E, Fritschi L: Risk of childhood acute lymphoblastic leukaemia following parental occupational exposure to pesticides. Occup Environ Med 2012, 69(11):846-9.
• [11]Hasle H, Clemmensen IH, Mikkelsen M: Risk of leukaemia and solid tumors in individuals with Down’s syndrome. Lancet 2000, 355:165-9.
• [12]Koushik A, King WD, McLaughlin JR: An ecologic study of childhood leukemia and population mixing in Ontario, Canada. Cancer Causes Control 2001, 12:483-90.
• [13]Greaves MF: Childhood Leukemia. BMJ 2002, 324:283-7.
• [14]Gardner MJ, Snee MP, Hall AJ, Powell CA, Downes S, Terrell JD: Results of case–control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ 1990, 300:423-9.
• [15]Roman E, Doyle P, Maconochie N, Davies G, Smith PG, Beral V: Cancer in children of nuclear industry employees: report on children aged under 25 years from nuclear industry family study. BMJ 1999, 318:1443-50.
• [16]Greaves M: Infection, immune responses and the aetiology of childhood leukaemia. Nature Rev Cancer 2006, 6:193-203.
• [17]Kinlen LJ: Epidemiological evidence for an infective basis in childhood leukaemia. Br J Cancer 1995, 71:1-5.
• [18]Kinlen LJ: Childhood leukemia and population mixing. Pediatrics 2004, 114:330-1.
• [19]Chan LC, Lam TH, Li CK, Lau YL, Li CK, Yuen HL, et al.: Is the timing of exposure to infection a major determinant of acute lymphoblastic leukemia in Hong Kong? Paediatr Perinat Epidem 2002, 16:154-65.
• [20]Petridou E, Dalamaga M, Mentis A, Skalkidou A, Moustaki M, Karphatios T, et al.: Evidence on the infectious etiology of childhood leukemia: the role of low herd immunity. Cancer Causes Control 2001, 12:645-52.
• [21]Migliorini G, Fiege B, Hosking FJ, Ma Y, Kumar R, Sherborne AL, et al.: Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. Blood 2013, 122(19):3298-307.
• [22]Treviño LR, Yangw , French D, Hunger S, Carroll WL, Devidas M, et al.: Germline genomic variations associated with childhood acute lymphoblastic leukemia. Nat Genet 2009, 41(9):1001-5.
• [23]Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, et al.: Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet 2009, 41(9):1006-10.
• [24]van de Schans SA, van Spronsen DJ, Hooijkaas H, Janssen-Heijnen ML, Coebergh JW: Excess of autoimmune and chronic inflammatory disorders in patients with lymphoma compared with all cancer patients: a cancer registry-based analysis in the south of the Netherlands. Autoimmun Rev 2011, 10(4):228-34.
• [25]Mellemkjaer L, Alexander F, Olsen JH: Cancer among children of parents with autoimmune diseases. Br J Cancer 2000, 82(7):1353-7.
• [26]Till M, Rapson N, Smith PG: Family studies in acute leukaemia in childhood: a possible association with autoimmune disease. Br J Cancer 1979, 40(1):62-71.
• [27]Wen WQ, Shu XO, Sellers T, Bhatia S, Lampkin B, Robison LL: Family history of cancer and autoimmune disease and risk of leukemia in infancy: a report from the Children’s Cancer Group (United States and Canada). Cancer Causes Control 1998, 9(2):161-71.
• [28]Gómez-Puerta JA, Cervera R: Diagnosis and classification of the antiphospholipid syndrome. J Autoimmun 2014, 48–49:20-5.