“Neuroendocrine adenoma of the middle ear with the history of otitis media and carcinoma of the cheek: a case report”

BMC Research Notes

Khabti Almuhanna¹ 

[1] Department of Otolyringoscopy, Prince Sultan Military Medical City Hospital, Riyadh, Saudi Arabia

关键词: Saudi Arabia;    Otitis media;    Middle ear;    Neuroendocrine adenoma;   

Others  :  1130491
DOI  :  10.1186/1756-0500-7-532

 received in 2013-09-06, accepted in 2014-07-30,  发布年份 2014

【 摘 要 】

Background

Neuroendocrine adenomas of the middle ear are rare benign tumors deriving from middle ear mucosal cell with both neuroendocrine and epithelial properties. Approximately one hundred cases have been reported in the literature. Here we report a patient with neuroendocrine adenoma of the middle ear with the history of otitis media; the patient earlier had received radiotherapy for the treatment of basal cell carcinoma.

Case presentation

A 49- year- old Saudi man presented with a progressive hearing loss and fullness in the left ear with the history of otitis media for which he had undergone myringotomy and ventilating tubes insertion. Earlier at the age of 45 years this patient was given radiotherapy for the treatment of basal cell carcinoma in his cheek. The otoscopy showed a protruded external ear mass obscuring the tympanic membrane. Microscopy and histological examination suggested an endocrine adenoma of the middle ear. The computerized tomography scan of the temporal bone showed an extensive soft tissue mass without any osteolysis. Histological and immunohistochemical examination following surgical excision confirmed the diagnosis of neuroendocrine adenoma of the middle ear.

Conclusion

A rare case of neuroendocrine adenoma of the middle ear with earlier history of otitis media and carcinoma of the cheek is presented here. Surgical excision of mass resulted in uneventful recovery. Although the etiologic factors leading to the disease is far from clear, the role of radiotherapy given for the treatment of basal cell carcinoma may not be ruled out.

【 授权许可】

   
2014 Almuhanna; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Derlacki E, Barney P: Adenomatous tumors of the middle ear and mastoid. Laryngoscope 1976, 86:1123-1135.
• [2]Berns S, Pearl G: Middle ear adenoma. Arch Pathol Lab Med 2006, 130:1067-1069.
• [3]Lott Limbach AA, Hoschar AP, Thompson LD, Stelow EB, Chute DJ: Middle ear adenomas stain for two cell populations and lack myoepithelial cell differentiation. Head and Neck Pathol 2012, 6:345-353.
• [4]Amble FR, Harner SG, Weiland LH, McDonald TJ, Facer GW: Middle ear adenoma and adenocarcinoma. Otolaryngol Head Neck Surg 1993, 109:871-876.
• [5]Torske K, Thompson L: Adenoma versus carcinoid tumor of the middle ear: a study of 48 cases and review of the literature. Mod Pathol 2002, 15:543-555.
• [6]Bakhos D, Lescanne E, Fetissof F, Robier A, Morinière S: Neuroendocrine adenoma of the middle ear: a case study. Eur Arch Otorhinolaryngol 2007, 264:1525-1528.
• [7]Saliba I, Evrard AS: Middle ear glandular neoplasm: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series. Cases J 2009, 2:6508. BioMed Central Full Text
• [8]Ayache S, Braccini F, Fernandes M, Thomassin JM: Adenoma of the middle ear: a rare and misleading lesion. Otol neurol 2002, 23:988-991.
• [9]Jones SEM, Yung MW, Orell JM, Norris A: Adenoma in the middle ear: a report of two cases. J Laryngol Otol 2001, 115:216-219.
• [10]Orendorz-Fraczkowska K, Jaworska M, Gawron W, Badowski R: Middle ear ceruminous adenoma as a rare cause of hearing loss and vertigo: case reports. Auris Nausus larynx 2005, 32:393-397.
• [11]Jahrsdoerfer RA, Fechner RE, Moon CN, Selman JW, Poxell JB: Adenoma of the middle ear. Laryngoscope 1983, 93:1041-1044.
• [12]Maintz D, Stupp C, Krueger K, Wustrow J, Lackner K: MRI and CT Of adenomatous tumors of the middle ear. Neuroradiology 2001, 43:58-61.
• [13]Ramsey MJ, Nadol JB, Pilch BZ, McKenna MJ: Carcinoid tumor of the middle ear: clinical features, recurrences, and metastases. Laryngoscope 2005, 115:1660-1666.
• [14]Ron E: Cancer risks from medical radiation. Health Phys 2003, 85:47-59.
• [15]Lichter MD, Karagas MR, Mott LA, Spencer SK, Stukel TA, Greenberg ER: Therapeutic ionizing radiation and the incidence of basal cell carcinoma and squamous cell carcinoma. The New Hampshire Skin Cancer Study Group. Arch Dermatol 2000, 136:1007-1011.