期刊论文详细信息
BMC Psychiatry
Personality dimensions of schizophrenia patients compared to control subjects by gender and the relationship with illness severity
Lourdes Martorell1  Elisabet Vilella1  Alfonso Gutiérrez-Zotes1  María J Cortés1  Lorena Moreno1  Ana M Gaviria1  Sònia Setó1  Begoña Verge1  Yolanda Alonso1  Carmen Miralles1 
[1] Unitat de Psiquiatria, Hospital Universitari Psiquiàtric Institut Pere Mata, IISPV, Universitat Rovira i Virgili, CIBERSAM, C/ SantLlorenç, 21, 43201 Reus, Spain
关键词: Illness severity;    Gender;    TCI-R;    Personality dimensions;    Schizophrenia;   
Others  :  1123561
DOI  :  10.1186/1471-244X-14-151
 received in 2013-10-17, accepted in 2014-05-16,  发布年份 2014
PDF
【 摘 要 】

Background

Personality traits and schizophrenia present gender differences; however, gender has not been considered in most studies on personality and schizophrenia. This study aims to identify the different personality dimensions of schizophrenia patients and healthy control subjects by gender and to explore the relationship between personality dimensions and illness severity variables by analyzing data for males and females separately.

Methods

Temperament and Character Inventory-Revised dimensions were compared by gender between 161 schizophrenia patients and 214 healthy controls from a population-based sample using independent t-tests. We then investigated whether personality dimensions are related to illness severity variables using correlation analyses and bivariate logistic regression, also by gender.

Results

The patients had significantly higher scores for harm avoidance (HA) and self-transcendence (ST) and lower scores for reward dependence (RD), cooperativeness (C), and self-directedness (SD) than the controls. Similar results were obtained when the sample was stratified by gender, however the differences were higher and more significant for HA among males and for RD among females. The number of admissions to a psychiatric hospital positively correlated with novelty seeking (NS) in males and negatively with SD in females. In males, SD and ST negatively correlated with the number of suicide attempts.

Conclusions

Male and female patients present difficulties for regulating and adapting behavior to achieve goals (SD) and for identifying and accepting others (C), as well as a great sense of spirituality and universe identification (ST). However, male patients are more characterized by being fearful, doubtful and easily fatigued (HA), while female patients are characterized by presenting difficulties maintaining and pursuing associated reward behaviors (RD). Furthermore, male and female patients who are frequently admitted to psychiatric hospitals and male patients who attempt suicide should be evaluated regarding their personality dimensions. Future studies assessing the relationship between personality dimensions and the clinical features of schizophrenia should consider gender differences.

【 授权许可】

   
2014 Miralles et al.; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20150216035539121.pdf 267KB PDF download
Figure 1. 38KB Image download
【 图 表 】

Figure 1.

【 参考文献 】
  • [1]Eklund M, Hansson L, Bengtsson-Tops A: The influence of temperament and character on functioning and aspects of psychological health among people with schizophrenia. Eur Psychiatry 2004, 19(1):34-41.
  • [2]Jetha MK, Goldberg JO, Schmidt LA: Temperament and its relation to social functioning in schizophrenia. Int J Soc Psychiatry 2013, 59(3):254-263.
  • [3]Lysaker PH, Davis LW: Social function in schizophrenia and schizoaffective disorder: associations with personality, symptoms and neurocognition. Health Qual Life Outcomes 2004, 2:15. BioMed Central Full Text
  • [4]Remschmidt H, Theisen F: Early-onset schizophrenia. Neuropsychobiology 2012, 66(1):63-69.
  • [5]Skokou M, Gourzis P: Demographic features and premorbid personality disorder traits in relation to age of onset and sex in paranoid schizophrenia. Psychiatry Res 2014, 215(3):554-559.
  • [6]Newton-Howes G, Tyrer P, North B, Yang M: The prevalence of personality disorder in schizophrenia and psychotic disorders: systematic review of rates and explanatory modelling. Psychol Med 2008, 38(8):1075-1082.
  • [7]Widiger TA: Integrating normal and abnormal personality structure: a proposal for DSM-V. J Pers Disord 2011, 25(3):338-363.
  • [8]Cloninger CR, Svrakic DM, Przybeck TR: A psychobiological model of temperament and character. Arch Gen Psychiatry 1993, 50(12):975-990.
  • [9]Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M: Personality traits and schizophrenia: evidence from a case–control study and meta-analysis. Psychiatry Res 2012, 198(1):7-11.
  • [10]Sim M, Kim JH, Yim SJ, Cho SJ, Kim SJ: Increase in harm avoidance by genetic loading of schizophrenia. Compr Psychiatry 2012, 53(4):372-378.
  • [11]Smith MJ, Cloninger CR, Harms MP, Csernansky JG: Temperament and character as schizophrenia-related endophenotypes in non-psychotic siblings. Schizophr Res 2008, 104(1–3):198-205.
  • [12]Szöke A, Schürhoff F, Ferhadian N, Bellivier F, Rouillon F, Leboyer M: Temperament in schizophrenia: a study of the tridimensional personality questionnaire (TPQ). Eur Psychiatry 2002, 17(7):379-383.
  • [13]Ochoa S, Usall J, Cobo J, Labad X, Kulkarni J: Gender differences in schizophrenia and first-episode psychosis: a comprehensive literature review. Schizophr Res Treatment 2012, 2012:916198.
  • [14]Iniesta R, Ochoa S, Usall J: Gender differences in service use in a sample of people with schizophrenia and other psychoses. Schizophr Res Treatment 2012, 2012:365452.
  • [15]Abu-Akel A, Bo S: Superior mentalizing abilities of female patients with schizophrenia. Psychiatry Res 2013, 210(3):794-799.
  • [16]Miettunen J, Veijola J, Lauronen E, Kantojärvi L, Joukamaa M: Sex differences in Cloninger’s temperament dimensions–a meta-analysis. Compr Psychiatry 2007, 48(2):161-169.
  • [17]Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Saitoh O, Murray RM, Okabe S, Kunugi H: Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI). Psychiatry Res 2008, 160(2):175-183.
  • [18]Guillem F, Bicu M, Semkovska M, Debruille JB: The dimensional symptom structure of schizophrenia and its association with temperament and character. Schizophr Res 2002, 56(1–2):137-147.
  • [19]Ritsner M, Susser E: Temperament types are associated with weak self-construct, elevated distress and emotion-oriented coping in schizophrenia: evidence for a complex vulnerability marker? Psychiatry Res 2004, 128(3):219-228.
  • [20]Herrán A, Sierra-Biddle D, Cuesta MJ, Sandoya M, Vázquez-Barquero JL: Can personality traits help us explain disability in chronic schizophrenia? Psychiatry Clin Neurosci 2006, 60(5):538-545.
  • [21]Boeker H, Kleiser M, Lehman D, Jaenke L, Bogerts B, Northoff G: Executive dysfunction, self, and ego pathology in schizophrenia: an exploratory study of neuropsychology and personality. Compr Psychiatry 2006, 47(1):7-19.
  • [22]Calvó de Padilla M, Padilla E, González Alemán G, Bourdieu M, Guerrero G, Strejilevich S, Escobar JI, Svrakic N, Cloninger CR, de Erausquin GA: Temperament traits associated with risk of schizophrenia in an indigenous population of Argentina. Schizophr Res 2006, 83(2–3):299-302.
  • [23]Gonzalez-Torres MA, Inchausti L, Ibáñez B, Aristegui M, Fernández-Rivas A, Ruiz E, Fernandez E, Bayón C: Temperament and character dimensions in patients with schizophrenia, relatives, and controls. J Nerv Ment Dis 2009, 197(7):514-519.
  • [24]Cortés MJ, Valero J, Gutiérrez-Zotes JA, Hernández A, Moreno L, Jariod M, Martorell L, Vilella E, Labad A: Psychopathology and personality traits in psychotic patients and their first-degree relatives. Eur Psychiatry 2009, 24(7):476-482.
  • [25]Margetić BA, Jakovljević M, Ivanec D, Margetić B: Temperament, character, and quality of life in patients with schizophrenia and their first-degree relatives. Compr Psychiatry 2011, 52(4):425-430.
  • [26]Calati R, Giegling I, Rujescu D, Hartmann AM, Möller HJ, de Ronchi D, Serretti A: Temperament and character of suicide attempters. J Psychiatr Res 2008, 42(11):938-945.
  • [27]Aukst Margetić B, Jakovljević M, Ivanec D, Marčinko D, Margetić B, Jakšić N: Current suicidality and previous suicidal attempts in patients with schizophrenia are associated with different dimensions of temperament and character. Psychiatry Res 2012, 200(2–3):120-125.
  • [28]Albayrak Y, Ekinci O, Cayköylü A: Temperament and character personality profile in relation to suicide attempts in patients with schizophrenia. Compr Psychiatry 2012, 53(8):1130-1136.
  • [29]Rabinowitz J, Levine SZ, Häfner H: A population based elaboration of the role of age of onset on the course of schizophrenia. Schizophr Res 2006, 88(1–3):96-101.
  • [30]Norman RMG, Malla AK, McLean TS, McIntosh EM, Neufeld RWJ, Voruganti LP, Cortese L: An evaluation of a stress management program for individuals with schizophrenia. Schizophr Res 2002, 58(2–3):293-303.
  • [31]Ascher-Svanum H, Zhu B, Faries D, Ernst FR: A comparison of olanzapine and risperidone on the risk of psychiatric hospitalization in the naturalistic treatment of patients with schizophrenia. Ann Gen Hosp Psychiatry 2004, 3(1):11. BioMed Central Full Text
  • [32]Durbin A, Rudoler D, Durbin J, Laporte A, Callaghan RC: Examining patient race and area predictors of inpatient admission for schizophrenia among hospital users in California. J Immigr Minor Health 2013. in press
  • [33]Simone C, Carolin L, Max S, Reinhold K: Associations between community characteristics and psychiatric admissions in an urban area. Soc Psychiatry Psychiatr Epidemiol 2013, 48(11):1797-1808.
  • [34]Sung T-I, Chen M-J, Lin C-Y, Lung S-C, Su H-J: Relationship between mean daily ambient temperature range and hospital admissions for schizophrenia: results from a national cohort of psychiatric inpatients. Sci Total Environ 2011, 410–411:41-46.
  • [35]Vázquez-Barquero JL: SCAN: Cuestionarios Para La Evaluación Clínica En Neuropsiquiatría. Madrid: Meditor; 1993.
  • [36]Goldberg DP, Hillier VF: A scaled version of the General Health Questionnaire. Psychol Med 1979, 9(1):139-145.
  • [37]Lobo A, Pérez-Echeverría MJ, Artal J: Validity of the scaled version of the General Health Questionnaire (GHQ-28) in a Spanish population. Psychol Med 1986, 16(1):135-140.
  • [38]Gutiérrez-Zotes JA, Bayón C, Montserrat C, Valero J, Labad A, Cloninger CR, Fernández-Aranda F: Temperament and Character Inventory Revised (TCI-R). Standardization and normative data in a general population sample. Actas Esp Psiquiatr 2004, 32(1):8-15.
  • [39]Gutiérrez-Zotes JA, Cortés MJ, Valero J, Pena J, Labad A: Psychometric properties of the abbreviated Spanish version of TCI-R (TCI-140) and its relationship with the Psychopathological Personality Scales (MMPI-2 PSY-5) in patients. Actas Esp Psiquiatr 2005, 33(4):231-237.
  • [40]Ritsner MS, Blumenkrantz H: Predicting domain-specific insight of schizophrenia patients from symptomatology, multiple neurocognitive functions, and personality related traits. Psychiatry Res 2007, 149(1–3):59-69.
  • [41]Lange LA, Kampov-Polevoy AB, Garbutt JC: Sweet liking and high novelty seeking: independent phenotypes associated with alcohol-related problems. Alcohol Alcohol 2010, 45(5):431-436.
  • [42]Kim JH, Kim D, Park S-H, Lee HB, Chung EK: Novelty-seeking among schizophrenia patients with comorbid alcohol abuse. J Nerv Ment Dis 2007, 195(7):622-624.
  • [43]Määttänen I, Jokela M, Hintsa T, Firtser S, Kähönen M, Jula A, Raitakari OT, Keltikangas-Järvinen L: Testosterone and temperament traits in men: Longitudinal analysis. Psychoneuroendocrinology 2013, 38(10):2243-2248.
  • [44]Gade-Andavolu R, Macmurray J, Comings DE, Calati R, Chiesa A, Serretti A: Association between the estrogen receptor TA polymorphism and Harm avoidance. Neurosci Lett 2009, 467(2):155-158.
  • [45]Tseng HC, Chi MH, Lee L-T, Tsai HC, Lee IH, Chen KC, Yang YK, Chen PS: Sex-specific associations between plasma oxytocin levels and schizotypal personality features in healthy individuals. J Psychiatr Res 2014, 51:37-41.
  • [46]Rosenström T, Jokela M, Cloninger CR, Hintsanen M, Juonala M, Raitakari O, Viikari J, Keltikangas-Järvinen L: Associations between dimensional personality measures and preclinical atherosclerosis: the cardiovascular risk in Young Finns study. J Psychosom Res 2012, 72(5):336-343.
  • [47]Josefsson K, Merjonen P, Jokela M, Pulkki-Råback L, Keltikangas-Jarvinen L: Personality profiles identify depressive symptoms over Ten years? A population-based study. Depress Res Treat 2011, 2011:431314.
  • [48]Kendler KS, Gardner CO: Sex differences in the pathways to major depression: a study of opposite-sex twin pairs. Am J Psychiatry 2014, 171(4):426-435.
  • [49]Poustka L, Murray GK, Jääskeläinen E, Veijola J, Jones P, Isohanni M, Miettunen J: The influence of temperament on symptoms and functional outcome in people with psychosis in the Northern Finland 1966 Birth Cohort. Eur Psychiatry 2010, 25(1):26-32.
  • [50]Song YY, Kang JI, Kim SJ, Lee MK, Lee E, An SK: Temperament and character in individuals at ultra-high risk for psychosis and with first-episode schizophrenia: associations with psychopathology, psychosocial functioning, and aspects of psychological health. Compr Psychiatry 2013, 54(8):1161-1168.
  文献评价指标  
  下载次数:8次 浏览次数:14次