Admixture mapping of coronary artery calcification in African Americans from the NHLBI family heart study

BMC Genetics

Ingrid B Borecki¹  Michael A Province¹  Qunyuan Zhang¹  Haley Abel¹  Lihua Wang¹  Felicia Gomez¹ 

[1] Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine in St Louis, 4444 Forest Park Blvd, St Louis 63108, MO, USA

关键词: African Americans;    Admixture mapping;    Coronary artery calcification;   

Others  :  1178832
DOI  :  10.1186/s12863-015-0196-x

 received in 2014-10-17, accepted in 2015-04-06,  发布年份 2015

【 摘 要 】

Background

Coronary artery calcification (CAC) is an imaging biomarker of coronary atherosclerosis. In European Americans, genome-wide association studies (GWAS) have identified several regions associated with coronary artery disease. However, few large studies have been conducted in African Americans. The largest meta-analysis of CAC in African Americans failed to identify genome-wide significant variants despite being powered to detect effects comparable to effects identified in European Americans. Because CAC is different in prevalence and severity in African Americans and European Americans, admixture mapping is a useful approach to identify loci missed by GWAS.

Results

We applied admixture mapping to the African American cohort of the Family Heart Study and identified one genome-wide significant region on chromosome 12 and three potential regions on chromosomes 6, 15, and 19 that are associated with CAC. Follow-up studies using previously reported GWAS meta-analysis data suggest that the regions identified on chromosome 6 and 15 contain variants that are possibly associated with CAC. The associated region on chromosome 6 contains the gene for BMP-6, which is expressed in vascular calcific lesions.

Conclusions

Our results suggest that admixture mapping can be a useful hypothesis-generating tool to identify genomic regions that contribute to complex diseases in genetically admixed populations.

【 授权许可】

   
2015 Gomez et al.; licensee BioMed Central.

【 图 表 】

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