18F-FDG PET/CT oncologic imaging at extended injection-to-scan acquisition time intervals derived from a single-institution 18F-FDG-directed surgery experience: feasibility and quantification of 18F-FDG accumulation within 18F-FDG-avid lesions and background tissues

BMC Cancer

Stephen P Povoski²  Douglas A Murrey¹  Sabrina M Smith³  Edward W Martin²  Nathan C Hall¹ 

[1] Division of Molecular Imaging and Nuclear Medicine, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA

[2] Division of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA

[3] College of Medicine, The Ohio State University, Columbus, OH 43210, USA

关键词: Oncologic;    Real-time;    ¹⁸F-FDG-directed surgery;    Tumor-to-background ratio;    Lesion-to-background ratio;    Delayed imaging;    Injection-to-scan acquisition time;    SUV_max;    PET/CT;    ¹⁸F-FDG;   

Others  :  855661
DOI  :  10.1186/1471-2407-14-453

 received in 2014-02-10, accepted in 2014-06-13,  发布年份 2014

【 摘 要 】

Background

¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) is a well-established imaging modality for a wide variety of solid malignancies. Currently, only limited data exists regarding the utility of PET/CT imaging at very extended injection-to-scan acquisition times. The current retrospective data analysis assessed the feasibility and quantification of diagnostic ¹⁸F-FDG PET/CT oncologic imaging at extended injection-to-scan acquisition time intervals.

Methods

¹⁸F-FDG-avid lesions (not surgically manipulated or altered during ¹⁸F-FDG-directed surgery, and visualized both on preoperative and postoperative ¹⁸F-FDG PET/CT imaging) and corresponding background tissues were assessed for ¹⁸F-FDG accumulation on same-day preoperative and postoperative ¹⁸F-FDG PET/CT imaging. Multiple patient variables and ¹⁸F-FDG-avid lesion variables were examined.

Results

For the 32 ¹⁸F-FDG-avid lesions making up the final ¹⁸F-FDG-avid lesion data set (from among 7 patients), the mean injection-to-scan times of the preoperative and postoperative ¹⁸F-FDG PET/CT scans were 73 (±3, 70-78) and 530 (±79, 413-739) minutes, respectively (P < 0.001). The preoperative and postoperative mean ¹⁸F-FDG-avid lesion SUV_max values were 7.7 (±4.0, 3.6-19.5) and 11.3 (±6.0, 4.1-29.2), respectively (P < 0.001). The preoperative and postoperative mean background SUV_max values were 2.3 (±0.6, 1.0-3.2) and 2.1 (±0.6, 1.0-3.3), respectively (P = 0.017). The preoperative and postoperative mean lesion-to-background SUV_max ratios were 3.7 (±2.3, 1.5-9.8) and 5.8 (±3.6, 1.6-16.2), respectively, (P < 0.001).

Conclusions

¹⁸F-FDG PET/CT oncologic imaging can be successfully performed at extended injection-to-scan acquisition time intervals of up to approximately 5 half-lives for ¹⁸F-FDG while maintaining good/adequate diagnostic image quality. The resultant increase in the ¹⁸F-FDG-avid lesion SUV_max values, decreased background SUV_max values, and increased lesion-to-background SUV_max ratios seen from preoperative to postoperative ¹⁸F-FDG PET/CT imaging have great potential for allowing for the integrated, real-time use of ¹⁸F-FDG PET/CT imaging in conjunction with ¹⁸F-FDG-directed interventional radiology biopsy and ablation procedures and ¹⁸F-FDG-directed surgical procedures, as well as have far-reaching impact on potentially re-shaping future thinking regarding the “most optimal” injection-to-scan acquisition time interval for all routine diagnostic ¹⁸F-FDG PET/CT oncologic imaging.

【 授权许可】

   
2014 Povoski et al.; licensee BioMed Central Ltd.

【 图 表 】

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