Integrative study of pandemic A/H1N1 influenza infections: design and methods of the CoPanFlu-France cohort

BMC Public Health

Fabrice Carrat⁹  Antoine Flahault^1,11  Pierre Le Cann³  Michèle Legeas³  Michaël Schwarzinger¹  Laurent Abel⁴  Eric Vivier²  Pierre-Yves Boëlle⁹  Simon Cauchemez^1,10  Laurent Andreoletti⁸  Marianne Leruez-Ville⁶  Frédéric Vely²  Marie-Lise Gougeon⁵  Rosemary M Delabre⁹  Pascal Ferrari⁹  Michel Setbon^1,11  Nicolas Salez⁷  Xavier de Lamballerie³  Nathanael Lapidus⁹ 

[1] Observatoire Régional de la Santé PACA, Marseille, France;Centre d’Immunologie de Marseille-Luminy (CIML), Université de la Méditerranée UM 631, Campus de Luminy, 13288 Marseille, France;Ecole des Hautes Etudes en Sante Publique, Rennes, France;Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA;Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Paris, France;Laboratoire de Virologie, Hôpital Necker, AP-HP, Paris, France;Unité des Virus Emergents, UMR-D 190, Aix-Marseille université and Institut de Recherche pour le Développement, Marseille, France;IFR 53/EA-4303 (DAT/PPCIDH), Faculté de Médecine, Reims, France;Université Pierre et Marie Curie-Paris 6, UMR-S 707, F-75012 Paris, France;Medical Research Council Centre for Outbreak Analysis and Modeling, Department of Infectious Disease Epidemiology, Imperial College, London, UK;Ecole des Hautes Etudes en Sante Publique, Paris, France

关键词: France;    Risk factors;    Cohort study;    Influenza a virus H1N1 subtype;   

Others  :  1163558
DOI  :  10.1186/1471-2458-12-417

 received in 2012-03-25, accepted in 2012-06-07,  发布年份 2012

【 摘 要 】

Background

The risk of influenza infection depends on biological characteristics, individual or collective behaviors and the environmental context. The Cohorts for Pandemic Influenza (CoPanFlu) France study was set up in 2009 after the identification of the novel swine-origin A/H1N1 pandemic influenza virus. This cohort of 601 households (1450 subjects) representative for the general population aims at using an integrative approach to study the risk and characteristics of influenza infection as a complex combination of data collected from questionnaires regarding sociodemographic, medical, behavioral characteristics of subjects and indoor environment, using biological samples or environmental databases.

Methods/Design

Households were included between December 2009 and July 2010. The design of this study relies on systematic follow-up visits between influenza seasons and additional visits during influenza seasons, when an influenza-like illness is detected in a household via an active surveillance system. During systematic visits, a nurse collects individual and environmental data on questionnaires and obtains blood samples from all members of the household. When an influenza-like-illness is detected, a nurse visits the household three times during the 12 following days, and collects data on questionnaires regarding exposure and symptoms, and biological samples (including nasal swabs) from all subjects in the household. The end of the follow-up period is expected in fall 2012.

Discussion

The large amount of data collected throughout the follow-up will permit a multidisciplinary study of influenza infections. Additional data is being collected and analyzed in this ongoing cohort. The longitudinal analysis of these households will permit integrative analyses of complex phenomena such as individual, collective and environmental risk factors of infection, routes of transmission, or determinants of the immune response to infection or vaccination.

【 授权许可】

   
2012 Lapidus et al.; licensee BioMed Central Ltd.

【 图 表 】

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【 参考文献 】

• [1]Dawood FS, Jain S, Finelli L, Shaw MW, Lindstrom S, Garten RJ, Gubareva LV, Xu X, Bridges CB, Uyeki TM: Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009, 360:2605-2615.
• [2]World now at the start of 2009 influenza pandemic [http://www.who.int/mediacentre/news/statements/2009/h1n1_pandemic_phase6_20090611/en/index.html webcite].
• [3]Koita OA, Sangare L, Poudiougou B, Aboubacar B, Samake Y, Coulibaly T, Pronyk P, Salez N, Kieffer A, Ninove L, Flahault A, de Lamballerie X: A seroepidemiological study of pandemic A/H1N1(2009) influenza in a rural population of Mali. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 2011.
• [4]Dellagi K, Rollot O, Temmam S, Salez N, Guernier V, Pascalis H, Gérardin P, Fianu A, Lapidus N, Naty N, Tortosa P, Boussaïd K, Jaffar-Banjee M-C, Filleul L, Flahault A, Carrat F, Favier F, de Lamballerie X: Pandemic influenza due to pH1N1/2009 Virus: estimation of infection burden in Reunion Island through a prospective serosurvey, Austral Winter 2009. PLoS One 2011, 6:e25738.
• [5]Cauchemez S, Donnelly CA, Reed C, Ghani AC, Fraser C, Kent CK, Finelli L, Ferguson NM: Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States. N Engl J Med 2009, 361:2619-2627.
• [6]France AM, Jackson M, Schrag S, Lynch M, Zimmerman C, Biggerstaff M, Hadler J: Household transmission of 2009 influenza A (H1N1) virus after a school-based outbreak in New York City, April-May 2009. J Infect Dis 2010, 201:984-992.
• [7]Lee DH, Kim CW, Kim J-H, Lee JS, Lee MK, Choi JC, Choi BW, Choi S-H, Chung J-W: Risk factors for laboratory-confirmed household transmission of pandemic H1N1 2009 infection. Am J Infect Control 2010, 38:e43-e45.
• [8]Morgan OW, Parks S, Shim T, Blevins PA, Lucas PM, Sanchez R, Walea N, Loustalot F, Duffy MR, Shim MJ, Guerra S, Guerra F, Mills G, Verani J, Alsip B, Lindstrom S, Shu B, Emery S, Cohen AL, Menon M, Fry AM, Dawood F, Fonseca VP, Olsen SJ: Household transmission of pandemic (H1N1) 2009, San Antonio, Texas, USA, April-May 2009. Emerging Infect Dis 2010, 16:631-637.
• [9]Nishiura H, Oshitani H: Household Transmission of Influenza (H1N1-2009) in Japan: age-specificity and reduction of household transmission risk by Zanamivir Treatment. J Int Med Res 2011, 39:619-628.
• [10]Viboud C, Boëlle P-Y, Cauchemez S, Lavenu A, Valleron A-J, Flahault A, Carrat F: Risk factors of influenza transmission in households. Br J Gen Pract 2004, 54:684-689.
• [11]Cowling BJ, Chan K-H, Fang VJ, Cheng CKY, Fung ROP, Wai W, Sin J, Seto WH, Yung R, Chu DWS, Chiu BCF, Lee PWY, Chiu MC, Lee HC, Uyeki TM, Houck PM, Peiris JSM, Leung GM: Facemasks and hand hygiene to prevent influenza transmission in households: a cluster randomized trial. Ann Intern Med 2009, 151:437-446.
• [12]Simmerman JM, Suntarattiwong P, Levy J, Jarman RG, Kaewchana S, Gibbons RV, Cowling BJ, Sanasuttipun W, Maloney SA, Uyeki TM, Kamimoto L, Chotipitayasunondh T: Findings from a household randomized controlled trial of hand washing and face masks to reduce influenza transmission in Bangkok, Thailand. Influenza Other Respi Viruses 2011, 5:256-267.
• [13]Brankston G, Gitterman L, Hirji Z, Lemieux C, Gardam M: Transmission of influenza A in human beings. Lancet Infect Dis 2007, 7:257-265.
• [14]Coudeville L, Bailleux F, Riche B, Megas F, Andre P, Ecochard R: Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a bayesian random-effects model. BMC Med Res Methodol 2010, 10:18. BioMed Central Full Text
• [15]Bougnères P, Valleron A-J: Causes of early-onset type 1 diabetes: toward data-driven environmental approaches. J Exp Med 2008, 205:2953-2957.
• [16]Patel CJ, Bhattacharya J, Butte AJ: An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus. PLoS One 2010, 5:e10746.
• [17]Waksberg J: Sampling Methods for Random Digit Dialing. J Am Stat Assoc 1978, 73:40-46.
• [18]Dudoignon L, Vanheuverzwyn A: Coverage Optimization of the Telephone Surveys Thanks to the Inclusion of Mobile Phone Only Stratum.
• [19]Roy G, Vanheuverzwyn A: Mobile phone in sample surveys. Proceedings from International Conference on Improving Surveys (ICIS), Copenhagen (Denmark); 2002. 25–28 August
• [20]Databases - The population census [http://www.insee.fr/en/bases-de-donnees/default.asp?page=recensements.htm webcite].
• [21]Sentinelles network France - Weekly epidemiological record [http://sentiweb.org/ webcite].
• [22]Case Definitions for Infectious Conditions Under Public Health Surveillance [http://www.cdc.gov/osels/ph_surveillance/nndss/casedef/novel_influenzaA.htm webcite].
• [23]Carrat F, Pelat C, Levy-Bruhl D, Bonmarin I, Lapidus N: Planning for the next influenza H1N1 season: a modelling study. BMC Infect Dis 2010, 10:301. BioMed Central Full Text