Fatal co-infection with leptospirosis and dengue in a Sri Lankan male

BMC Research Notes

Murugapillai K Ragunathan¹  Gayan Ranasinghe¹  Nanthini Gnanapragash¹  Aruna Wijesinghe¹ 

[1] National Hospital of Sri Lanka, Colombo, Sri Lanka

关键词: Co-infection;    Leptospirosis;    Dengue fever;   

Others  :  1230888
DOI  :  10.1186/s13104-015-1321-7

 received in 2013-06-09, accepted in 2015-08-06,  发布年份 2015

【 摘 要 】

Background

Leptospirosis and dengue are endemic in countries with subtropical or tropical climates and have epidemic potential. The incidence of both these diseases peaks during monsoons and both diseases present with similar clinical manifestations making differentiation of leptospirosis from dengue difficult. It is important to distinguish leptospirosis from dengue as early antibiotic therapy in leptospirosis leads to a favourable outcome, while dengue has no specific treatment, yet early recognition is vital for close monitoring and careful fluid management. Despite the high prevalence of both these infections, co-infection of leptospirosis and dengue has not been reported previously in Sri Lanka. We present the first case of co-infection with leptospirosis and dengue in a Sri Lankan male.

Case presentation

A 52 year old previously healthy Sri Lankan male was admitted to our facility with a history of fever for 4 days associated with headache, generalized myalgia, reduced urine output. On examination, he was rational, hypotensive, tacycardic, tacypneic and he did not have clinical evidence of fluid leakage or pneumonitis. His serology showed high titre of dengue IgG and IgM and rising titre of leptospirosis antibody. His course of illness was complicated with septic shock, acute renal failure, acute respiratory distress syndrome and disseminated intravascular coagulation and he succumbed to his illness on the eighth day of admission.

Conclusion

In areas where both leptospirosis and dengue are endemic, both infections should be include in the differential diagnosis when evaluating patients with acute febrile illness and should consider the possibility of co-infection. Leptospirosis, being a condition having definitive antibiotic therapy, should always be ruled out even if the patient is positive for dengue serology in regions endemic to both these diseases as early initiation of antibiotic therapy can reduce mortality significantly.

【 授权许可】

   
2015 Wijesinghe et al.

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