Effectiveness of intra-articular injections of sodium bicarbonate and calcium gluconate in the treatment of osteoarthritis of the knee: a randomized double-blind clinical trial

BMC Musculoskeletal Disorders

Jorge L Rosado³  María del Carmen Caamaño³  Karla Elena Gonzalez-Romero²  Miguel Angel Duarte-Vázquez¹  Sandra García-Padilla² 

[1] Nucitec S.A. de C.V, Santiago de Querétaro, Mexico;Cindetec A.C, Parque Industrial Querétaro, Jurica 122, Santiago de Querétaro, C.P. 76220, Qro, Mexico;Universidad Autónoma de Querétaro, Santiago de Querétaro, Mexico

关键词: Sodium bicarbonate and calcium gluconate;    Knee;    Joint;    Osteoarthritis therapy;   

Others  :  1229771
DOI  :  10.1186/s12891-015-0568-4

 received in 2014-08-26, accepted in 2015-04-29,  发布年份 2015

【 摘 要 】

Background

A novel therapeutic management of osteoarthritis (OA) of the knee was assessed. The study aimed to evaluate the effect of monthly sodium bicarbonate with a single (SBCG1) or double dose (SBCG2) of calcium gluconate injections on OA of the knee; as well as the efficacy and safety of both SBCG interventions in the long term.

Methods

A double-blind parallel-group clinical trial with 74 knee OA patients was performed during 12 months, both SBCG interventions were followed-up for another 6mo after intervention. The outcome variables were the Western Ontario-McMaster University Osteoarthritis Index (WOMAC), the Lequesne’s functional index and joint-space width changes from serial radiographs.

Results

After 12 months, group SBCG1 decreased −14.8 (95% CI:-14.2, −17.0) and group SBCG2 decreased −14.6 (−16.9, −12.4) in the global WOMAC score, the mean changes represent 80% and 82% lessened pain, respectively. In the Lequesne Functional Index scale, SBCG1 decreased −11.9 (−10.4, −14.2) and SBCG2 decreased -11.9 (−13.8, −10.0), representing 66 and 69% of improvement. Both mean scores were maintained after intervention discontinued. SBCG2 improved the knees’ joint space width more than SBCG1 at 3 and 18 months. Both SBCG interventions were well tolerated after 12 months of treatment

Conclusion

A solution of sodium bicarbonate and calcium gluconate is effective on reducing the symptoms associated with OA. Its beneficial effect is maintained for one year of continuous monthly administration and at least for 6 months after the administration is discontinued. When the dose of calcium gluconate is increased, it prevents further narrowing of joint-space.

Trial registration

Clinicaltrials.gov NCT00977444 webcite September 11, 2009.

【 授权许可】

   
2015 García-Padilla et al.; licensee BioMed Central.

【 图 表 】

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