Endogenous ROS levels in C. elegans under exogenous stress support revision of oxidative stress theory of life-history tradeoffs

BMC Evolutionary Biology

Suzanne Estes⁴  Dee R Denver³  Leigh C Latta¹  Samson W Smith² 

[1] Biology Department, Reed College, Portland, 97202, OR, USA;Current address: Department of Biology and Microbiology, South Dakota State University, Brookings, 57007, SD, USA;Department of Zoology, Oregon State University, Corvallis, 97331, OR, USA;Department of Biology, Portland State University, Portland, 97201, OR, USA

关键词: Resource allocation;    Lifespan;    Free radicals;    Fitness;    Aging;   

Others  :  1118122
DOI  :  10.1186/s12862-014-0161-8

 received in 2014-04-22, accepted in 2014-07-14,  发布年份 2014

【 摘 要 】

Background

The oxidative stress theory of life-history tradeoffs states that oxidative stress caused by damaging free radicals directly underpins tradeoffs between reproduction and longevity by altering the allocation of energetic resources between these tasks. We test this theory by characterizing the effects of exogenous oxidative insult and its interaction with thermal stress and diet quality on a suite of life-history traits and correlations in Caenorhabditis elegans nematodes. We also quantify demographic aging rates and endogenous reactive oxygen species (ROS) levels in live animals.

Results

Our findings indicate a tradeoff between investment in reproduction and antioxidant defense (somatic maintenance) consistent with theoretical predictions, but correlations between standard life-history traits yield little evidence that oxidative stress generates strict tradeoffs. Increasing oxidative insult, however, shows a strong tendency to uncouple positive phenotypic correlations and, in particular, to reduce the correlation between reproduction and lifespan. We also found that mild oxidative insult results in lower levels of endogenous ROS accompanied by hormetic changes in lifespan, demographic aging, and reproduction that disappear in combined-stress treatments--consistent with the oxidative stress theory of aging.

Conclusions

Our findings demonstrate that oxidative stress is a direct contributor to life-history trait variation and that traditional tradeoffs are not necessary to invoke oxidative stress as a mediator of relationships between life-history traits, supporting previous calls for revisions to theory.

【 授权许可】

   
2014 Smith et al.; licensee BioMed Central Ltd

【 图 表 】

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