Ambient air pollution and birth defects in Haikou city, Hainan province

BMC Pediatrics

Qingguo Zhao²  Lichun Fan¹  Li Wu²  Zhijiang Liang² 

[1] Hainan Women and Children Hospital, Haikou, China;Guangdong Women and Children Hospital, Guangzhou, China

关键词: NO2;    SO2;    PM10;    Birth defects;    Air pollution;   

Others  :  1113341
DOI  :  10.1186/s12887-014-0283-6

 received in 2014-06-11, accepted in 2014-10-20,  发布年份 2014

【 摘 要 】

Background

Evidence shows exposure to ambient air pollution during pregnancy was associated with an increased risk of adverse birth outcomes, such as preterm birth, low birth weight and intrauterine growth retardation, but the results for birth defects have been inconsistent.

Methods

The data on birth defects was collected from the Birth Defects Monitoring Network of Haikou city. Air pollution data for PM₁₀, SO₂ and NO₂ were obtained from Haikou Environmental Monitoring Center. Logistic regression analysis was used to evaluate these associations.

Results

The risk of birth defects was related to PM₁₀ levels (adjusted OR = 1.039; 95% CI = 1.016-1.063) and SO₂ levels (adjusted OR = 0.843; 95% CI = 0.733-0.969) for the second month of pregnancy. In the third month of pregnancy, the risk of birth defects was also related to PM10 levels (adjusted OR = 1.066; 95% CI = 1.043-1.090) and SO₂ levels (adjusted OR = 0.740; 95% CI = 0.645-0.850).

Conclusion

The study provides evidence that exposure to PM₁₀ and SO₂ during the second and third month of pregnancy may associated with the risk of birth defects.

【 授权许可】

   
2014 Liang et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Mainolfi MB, Salihu HM, Wilson RE, Mbah AK: Low-level exposure to air pollution and risk of adverse birth outcomes in Hillsborough County, Florida. J Occup Environ Med 2013, 55(5):490-494.
• [2]Laumbach RJ: Outdoor air pollutants and patient health. Am Fam Physician 2010, 81(2):175-180.
• [3]Bobak M: Outdoor air pollution, low birth weight, and prematurity. Environ Health Perspect 2000, 108(2):173-176.
• [4]Rich DQ, Demissie K, Lu SE, Kamat L, Wartenberg D, Rhoads GG: Ambient air pollutant concentrations during pregnancy and the risk of fetal growth restriction. J Epidemiol Community Health 2009, 63(6):488-496.
• [5]Sram RJ, Binkova B, Dejmek J, Bobak M: Ambient air pollution and pregnancy outcomes: a review of the literature. Environ Health Perspect 2005, 113(4):375-382.
• [6]Wilhelm M, Ritz B: Residential proximity to traffic and adverse birth outcomes in Los Angeles county, California, 1994–1996. Environ Health Perspect 2003, 111(2):207-216.
• [7]Zhao Q, Liang Z, Tao S, Zhu J, Du Y: Effects of air pollution on neonatal prematurity in Guangzhou of China: a time-series study.Environ Health 2011, 10:2.
• [8]Smrcka V, Leznarova D: Environmental pollution and the occurrence of congenital defects in a 15-year period in a south Moravian district. Acta Chir Plast 1998, 40(4):112-114.
• [9]Ritz B, Yu F, Fruin S, Chapa G, Shaw GM, Harris JA: Ambient air pollution and risk of birth defects in Southern California. Am J Epidemiol 2002, 155(1):17-25.
• [10]Hansen CA, Barnett AG, Jalaludin BB, Morgan GG: Ambient air pollution and birth defects in Brisbane, Australia.PLoS One 2009, 4(4):e5408.
• [11][http://www.marchofdimes.com/downloads/Birth_Defects_Report-PF.pdf] webcite Christianson A, Howson C, Modell B: March of dimes global report on birth defects. White Plains, New York: March or Dimes Foundation, (accessed October 19, 2010); 2006.
• [12]China action to improve constitution of birth population quality and reduce birth defects and disabilities (2002–2010) Zhongguo Sheng Yu Jian Kang Za Zhi 2002, 13:98-101.
• [13]Dai L, Zhou G, Zhu J, Miao L, Wang Y, Wu Y, Liang J, Mao M: Impacts of birth defects on perinatal deaths in Chinese population. Zhonghua Liu Xing Bing Xue Za Zhi 2004, 25:138-141.
• [14][www.eurocat.ulster.ac.uk/pubdata] webcite Seller M: Genetic causes of congential anomalies and their interaction with envirmmental factors. EUROCAT Special Report The environmental causes of congenital anomalies: a review of the literature. (Available at: Accessed: 10 December 2008); 2004.
• [15]Wyszynski DF, Wu T: Prenatal and perinatal factors associated with isolated oral clefting. Cleft Palate Craniofac J 2002, 39(3):370-375.
• [16]Wilson J: Handbook of Teratology(Wilson JG & Frasor Foeds). In Embryo toxicity of drugs in man. Plenum, New York; 1997.
• [17]Strickland MJ, Klein M, Correa A, Reller MD, Mahle WT, Riehle-Colarusso TJ, Botto LD, Flanders WD, Mulholland JA, Siffel C, Marcus M, Tolbert PE: Ambient air pollution and cardiovascular malformations in Atlanta, Georgia, 1986–2003. Am J Epidemiol 2009, 169(8):1004-1014.
• [18]Gilboa SM, Mendola P, Olshan AF, Langlois PH, Savitz DA, Loomis D, Herring AH, Fixler DE: Relation between ambient air quality and selected birth defects, seven county study, Texas, 1997–2000. Am J Epidemiol 2005, 162(3):238-252.
• [19]Hwang BF, Jaakkola JJ: Ozone and other air pollutants and the risk of oral clefts. Environ Health Perspect 2008, 116(10):1411-1415.