The impact of different GFR estimating equations on the prevalence of CKD and risk groups in a Southeast Asian cohort using the new KDIGO guidelines

BMC Nephrology

Piyamitr Sritara²  Bunlue Hengprasith³  Somlak Vanavanan¹  Sayan Cheepudomwit²  Anchalee Chittamma¹  Prin Vathesatogkit²  Sukit Yamwong²  Chagriya Kitiyakara² 

[1] Division of Clinical Chemistry, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10110, Thailand;Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok10110, Thailand;Medical and Health Office, Electricity Generating Authority of Thailand, Bangkruay, Nonthaburi 11130, Thailand

关键词: Thai;    kidney;    epidemiology, classification;    renal failure;    glomerular filtration rate;    EGAT;   

Others  :  1083212
DOI  :  10.1186/1471-2369-13-1

 received in 2011-04-26, accepted in 2012-01-06,  发布年份 2012

【 摘 要 】

Background

Recently, the Kidney Disease: Improving Global Outcomes (KDIGO) group recommended that patients with CKD should be assigned to stages and composite relative risk groups according to GFR (G) and proteinuria (A) criteria. Asians have among the highest rates of ESRD in the world, but establishing the prevalence and prognosis CKD is a problem for Asian populations since there is no consensus on the best GFR estimating (eGFR) equation. We studied the effects of the choice of new Asian and Caucasian eGFR equations on CKD prevalence, stage distribution, and risk categorization using the new KDIGO classification.

Methods

The prevalence of CKD and composite relative risk groups defined by eGFR from with Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI); standard (S) or Chinese(C) MDRD; Japanese CKD-EPI (J-EPI), Thai GFR (T-GFR) equations were compared in a Thai cohort (n = 5526)

Results

There was a 7 fold difference in CKD_3-5 prevalence between J-EPI and the other Asian eGFR formulae. CKD_3-5 prevalence with S-MDRD and CKD-EPI were 2 - 3 folds higher than T-GFR or C-MDRD. The concordance with CKD-EPI to diagnose CKD_3-5 was over 90% for T-GFR or C-MDRD, but they only assigned the same CKD stage in 50% of the time. The choice of equation also caused large variations in each composite risk groups especially those with mildly increased risks. Different equations can lead to a reversal of male: female ratios. The variability of different equations is most apparent in older subjects. Stage G3aA1 increased with age and accounted for a large proportion of the differences in CKD_3-5 between CKD-EPI, S-MDRD and C-MDRD.

Conclusions

CKD prevalence, sex ratios, and KDIGO composite risk groupings varied widely depending on the equation used. More studies are needed to define the best equation for Asian populations.

【 授权许可】

   
2012 Kitiyakara et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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