Antioxidant and anti-inflammatory activities of selected Chinese medicinal plants and their relation with antioxidant content

BMC Complementary and Alternative Medicine

Balaram Vysetti¹  Manavalan Satyanarayanan¹  Ming Jie Wu³  Gerald Münch²  Kirubakaran Shanmugam⁴  Paul T Smith³  John Bartlett³  Narsimha Reddy³  Sang Chul Jeong³  Sundar Rao Koyyalamudi⁵  Lin Zhang³  Anjaneya S Ravipati³ 

[1] CSIR-National Geophysical Research Institute, Uppal Road, Hyderabad, 500007, India;School of Medicine, University of Western Sydney, Locked Bag 1797, Penrith South DC, NSW 1797, Australia;School of Science and Health, Locked Bag 1797, Penrith South DC, NSW 1797, Australia;School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Queensland, 4811, Australia;Centre for Complementary Medicine Research, Locked Bag 1797, Penrith South DC, NSW 1797, Australia

关键词: Trace metals;    Flavonoids;    Phenolics;    Anti-inflammatory properties;    Antioxidant activities;   

Others  :  1231952
DOI  :  10.1186/1472-6882-12-173

 received in 2012-01-11, accepted in 2012-09-20,  发布年份 2012

【 摘 要 】

Background

The main aim of this study is to evaluate the antioxidant and anti-inflammatory properties of forty four traditional Chinese medicinal herbal extracts and to examine these activities in relation to their antioxidant content.

Methods

The antioxidant activities were investigated using DPPH radical scavenging method and yeast model. The anti-inflammatory properties of the herbal extracts were evaluated by measuring their ability to inhibit the production of nitric oxide and TNF-α in RAW 264.7 macrophages activated by LPS and IFN- γ, respectively. The cytotoxic effects of the herbal extracts were determined by Alomar Blue assay by measuring cell viability. In order to understand the variation of antioxidant activities of herbal extracts with their antioxidant contents, the total phenolics, total flavonoids and trace metal (Mg, Mn, Cu, Zn, Se and Mo) quantities were estimated and a correlation analysis was carried out.

Results

Results of this study show that significant levels of phenolics, flavonoids and trace metal contents were found in Ligustrum lucidum, Paeonia suffuticosa, Salvia miltiorrhiza, Sanguisorba officinalis,Spatholobus suberectus, Tussilago farfara and Uncaria rhyncophylla, which correlated well with their antioxidant and anti-inflammatory activities. Some of the plants displayed high antioxidant and anti-inflammatory activities but contained low levels of phenolics and flavonoids. Interestingly, these plants contained significant levels of trace metals (such as Zn, Mg and Se) which are likely to be responsible for their activities.

Conclusions

The results indicate that the phenolics, flavonoids and trace metals play an important role in the antioxidant activities of medicinal plants. Many of the plants studied here have been identified as potential sources of new antioxidant compounds.

【 授权许可】

   
2012 Ravipati et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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