Characteristics of patients with primary open angle glaucoma and normal tension glaucoma at a university hospital: a cross-sectional retrospective study

BMC Research Notes

Toru Nakazawa¹  Taiki Kokubun²  Hiroko Kayaba²  Mai Takahashi²  Sayaka Hashimoto²  Hideyuki Konno²  Kazuichi Maruyama²  Yu Yokoyama² 

[1] Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan;Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai 980-8574, Miyagi, Japan

关键词: Intraocular pressure;    Progression of visual field defects;    Visual field;    Glaucoma;   

Others  :  1230876
DOI  :  10.1186/s13104-015-1339-x

 received in 2014-10-18, accepted in 2015-08-12,  发布年份 2015

【 摘 要 】

Background

The characteristics of glaucoma patients and their response to therapy may differ by institution, region and country. Therefore, clinicians should understand the distinctiveness of their patients. Here, we profile primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients at a major university hospital in Japan.

Methods

This study included 523 eyes from 523 POAG and NTG patients who underwent full clinical ophthalmologic evaluations at Tohoku University Hospital. Clinical characteristics such as age, sex, visual acuity, intraocular pressure, Humphrey field analyzer-measured mean deviation (MD) and MD slope were collected retrospectively. MD slope was calculated from MD data that included the first baseline measurement of MD and 4 subsequent, consecutive, reliable measurements of MD. Refractive error was analyzed in a subgroup with no history of refractive surgery, including intraocular lens implantation. Patient characteristics were analyzed separately in the groups of patients with low (<15 mmHg) and high IOP (≥15 mmHg) and in the groups with MD slope ≥−1.0 and <−1.0 dB/year.

Results

Mean age, visual acuity (median), IOP, pre-treatment IOP (from patient history), refractive error and MD were 61.7 ± 12.5 years, −0.08 (interquartile range −0.08 to 0.05) LogMAR, 13.87 ± 3.37 mmHg, 18.35 ± 6.26 mmHg, −4.48 ± 3.81 diopters and −11.73 ± 8.83 dB, respectively. POAG and NTG patients had significant differences in mean age (63.4 ± 12.4 vs. 60.7 ± 12.5 years, P < 0.01), visual acuity, IOP (14.95 ± 4.20 vs. 13.21 ± 2.54 mmHg, P < 0.01) and MD (−13.85 ± 9.32 vs. −10.45 ± 8.27 dB, P < 0.01). Interestingly, MD slope was slightly steeper in the low-IOP group than in the high-IOP group, although the difference was not statistically significant (−0.85 vs. −0.70 dB/year, P = 0.31). Baseline MD was significantly worse in the group with MD slope <−1.0 dB/year than in the group with MD slope ≥−1.0 dB/year (−11.56 vs. −7.64 dB/year, P < 0.01).

Conclusions

We identified characteristics of glaucoma patients at a university hospital that may reflect the specialized nature of such an institution.

【 授权许可】

   
2015 Yokoyama et al.

【 图 表 】

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