Prevalence, genotype profile and risk factors for multiple human papillomavirus cervical infection in unimmunized female adolescents in Goiânia, Brazil: a community-based study

BMC Public Health

Maria de Fátima da Costa Alves⁴  Marise Amaral Rebouças Moreira¹  Maria Cecília Costa³  Luisa Lina Villa³  Mirian Socorro Cardoso Seixas²  Mônica Maria Danda Garcia²  Eleuse Machado de Britto Guimarães⁴  Lyana Elias Santos²  Marília Dalva Turchi⁴  Rosane Ribeiro Figueiredo Alves⁵ 

[1] Department of Pathology, Radiology and Diagnostic Imaging. School of Medicine, Federal University of Goiás, Goiânia, Brazil;Institute of Tropical Pathology and Public Health Federal University of Goias, Postgraduate Studies Program, Goiânia, Brazil;Department of Radiology and Basic Oncology, School of Medicine, University of São Paulo and Center for Translational Investigation in Oncology, ICESP, São Paulo, Brazil;Division of Adolescent Medicine, Department of Pediatrics, School of Medicine, Federal University of Goiás, Goiânia, Brazil;Rua 235 S/N Setor Universitário, Goiânia, Goiás, Brazil

关键词: Cytological abnormalities;    female;    Adolescents;    PCR-PGMY09/11/line blot hybridization/RFLP;    Multiple HPV infection;    Epidemiology;   

Others  :  1161585
DOI  :  10.1186/1471-2458-13-1041

 received in 2013-03-14, accepted in 2013-10-11,  发布年份 2013

【 摘 要 】

Background

The epidemiology of infection with multiple human papillomavirus (HPV) types in female adolescents is poorly understood. The purpose of this study was to explore the epidemiology of infection with multiple HPV types in adolescents and its association with demographic, behavioral and biological variables, as well as with cytological abnormalities.

Methods

This community-based study included 432 sexually active females between 15 and 19 years of age. Genotyping for 30 HPV types was performed using a reverse blot strip assay/restriction fragment length polymorphism. Unconditional multivariate logistic regression was performed to identify factors significantly associated with HPV infection. The association between HPV infection and cytological abnormalities was calculated using a prevalence ratio.

Results

The most common HPV types detected were 16, 51, 31, 52 and 18. Of the 121 HPV-positive women, 54 (44.6%) were infected with multiple HPV types. Having more than one lifetime sexual partner was associated with infection with any HPV infection, single HPV infection, and infection with multiple HPV types. The presence of cytological abnormalities was associated with infection with multiple HPV types.

Conclusions

Co-infecting HPV genotypes occur in a high proportion of sexually active adolescents. Socio-demographic or sexual behavior factors associated with single HPV infection were similar to those associated with multiple HPV types. The higher risk of cytological abnormalities conferred by infection with multiple HPV types suggests a potential role of co-infection in the natural history of HPV infection.

【 授权许可】

   
2013 Figueiredo Alves et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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