BMC Infectious Diseases | |
HPV clearance in postpartum period of HIV-positive and negative women: a prospective follow-up study | |
Silvana Maria Quintana1  Rodrigo Augustus Amaral de Morais3  Aparecida Yulie Yamamoto1  Renata Toscano Simoes3  Geraldo Duarte1  Patricia Pereira dos Santos Melli1  Francisco Inacio Bastos4  Emilia Moreira Jalil2  | |
[1] Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Sao Paulo, Brazil;ICICT/ENSP - Fundação Oswaldo Cruz - FIOCRUZ, Biblioteca de Manguinhos suite 229, Av. Brasil 4365, Rio de Janeiro RJ 21045-900, Brazil;Instituto de Ensino e Pesquisa da Santa Casa de, Belo Horizonte, Brazil;CAPES Visiting scholar, Imperial College London, London, UK | |
关键词: Polymerase Chain Reaction (PCR); Postpartum Period; Pregnancy; HIV; Human Papillomavirus; | |
Others : 1138272 DOI : 10.1186/1471-2334-13-564 |
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received in 2013-05-03, accepted in 2013-11-26, 发布年份 2013 | |
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【 摘 要 】
Background
HPV persistence is a key determinant of cervical carcinogenesis. The influence of postpartum on HPV clearance has been debated. This study aimed to assess HPV clearance in later pregnancy and postpartum among HIV-positive and negative women.
Methods
We conducted a follow-up study with 151 HPV-positive women coinfected with HIV, in 2007–2010. After baseline assessment, all women were retested for HPV infection using PCR in later pregnancy and after delivery. Multivariable logistic regressions assessed the putative association of covariates with HPV status in between each one of the successive visits.
Results
Seventy-one women (47%) have eliminated HPV between the baseline visit and their second or third visits. HIV-positive women took a significantly longer time (7.0 ± 3.8 months) to clear HPV, compared to those not infected by HIV (5.9 ± 3.0 months). HPV clearance was significantly more likely to take place after delivery than during pregnancy (84.5% x 15.5%).
Conclusions
Both HIV-positive and negative women presented a significant reduction in HPV infection during the postpartum period. HIV-positive status was found to be associated with a longer period of time to clear HPV infection in pregnant women.
【 授权许可】
2013 Jalil et al.; licensee BioMed Central Ltd.
【 预 览 】
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Figure 1. | 49KB | Image | ![]() |
【 图 表 】
Figure 1.
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