Composition and cytotoxic activity of essential oils from Xylopia aethiopica (Dunal) A. Rich, Xylopia parviflora (A. Rich) Benth.) and Monodora myristica (Gaertn) growing in Chad and Cameroon

BMC Complementary and Alternative Medicine

Chantal Menut⁴  Fabrice Fekam Boyom³  Pierre Michel Jazet Dongmo²  Youssouf Secka¹  Lucain Walbadet¹  Marcel Garcia⁴  Audrey Gallud⁴  Magali Gary-Bobo⁴  Lauve Rachel Yamthe Tchokouaha⁵  Patrick Valere Tsouh Fokou³  Jean Baptiste Hzounda³  Issakou Bakarnga-Via⁴ 

[1] Department of Biology, Faculty of Science, University of Adam Barka-Abeche, P.O. Box 1173, Abeche, Chad;Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon;Antimicrobial Agents Unit, Faculty of science, University of Yaoundé I, P.O Box 812, Yaoundé, Cameroon;IBMM, UMR 5247, Equipe Glyco et nanovecteurs pour le ciblage thérapeutique, Université de Montpellier 1, Faculté de Pharmacie, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier, France;Institute of Medical Research and Medicinal Plants Studies (IMPM), Yaoundé, Cameroon

关键词: Sesquiterpene;    Monoterpene;    ARPE-19 cells;    MCF-7 cells;    Cytotoxicity;    Essential oils;   

Others  :  1220198
DOI  :  10.1186/1472-6882-14-125

 received in 2014-02-03, accepted in 2014-03-27,  发布年份 2014

【 摘 要 】

Background

Cancer has become a global public health problem and the search for new control measures is urgent. Investigation of plant products such as essential oils from Monodora myristica, Xylopia aethiopica and Xylopia parviflora might lead to new anticancer therapy. In this study, we have investigated the antineoplastic activity of essential oils from fruits of these plants growing in Chad and Cameroon.

Methods

The essential oils obtained by hydrodistillation of fruits of Monodora myristica, Xylopia aethiopica and Xylopia parviflora collected in Chad and Cameroon were analyzed by GC-FID and GC-MS and investigated for their antiproliferative activity against the breast cancer cell line (MCF7).

Results

Overall, monoterpenes were mostly found in the six essential oils. Oils from X. aethiopica and X. parviflora from Chad and Cameroon mainly contain β-pinene at 24.6%, 28.2%, 35.7% and 32.9% respectively. Monodora myristica oils from both origins contain mainly α-phellandrene at 52.7% and 67.1% respectively. The plant origin did not significantly influence the chemical composition of oils. The six essential oils exerted cytotoxic activity against cancer (MCF-7) and normal cell lines (ARPE-19), with more pronounced effect on neoplastic cells in the majority of cases. The highest selectivity was obtained with the essential oils of X. parviflora from Chad and Cameroon (5.87 and 5.54) which were more cytotoxic against MCF-7 than against normal cell line (ARPE-19) with IC₅₀ values of 0.155 μL/mL and 0.166 μL/mL respectively.

Conclusions

Essential oils from fruits of Monodora myristica, Xylopia aethiopica and Xylopia parviflora have shown acceptable antineoplastic potency, and might be investigated further in this regard.

【 授权许可】

   
2014 Bakarnga-Via et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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