Characterisation of inflammatory response, coagulation, and radiological findings in Katayama fever: a report of three cases at the Medical University of Vienna, Austria

BMC Infectious Diseases

Michael Ramharter³  Wolfgang Graninger²  Rainer Gattringer¹  Fredrik Waneck⁵  Cihan Ay⁴  Heimo Lagler² 

[1] Institute of Hygiene, Microbiology and Tropical Medicine, Elisabethinen Hospital Linz, Fadingerstrasse 1, Linz 4020, Austria;Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria;Institut für Tropenmedizin, University of Tübingen, Wilhelmstraße 27, Tübingen 72074, Germany;Department of Medicine I, Division of Haematology and Haemostasiology, Medical, University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria;Departement of Biomedical Imaging and Image-guided Therapy, Division of Cardiovascular and Interventional Radiology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna 1090, Austria

关键词: Africa;    Radiology;    Coagulation;    Inflammation;    Katayama;    Schistosomiasis;   

Others  :  1127467
DOI  :  10.1186/1471-2334-14-357

 received in 2014-02-16, accepted in 2014-06-18,  发布年份 2014

【 摘 要 】

Background

Katayama fever is an acute clinical condition characterised by high fever, dry cough and general malaise occurring during early Schistosoma spp. infection. It is predominantly reported in travellers from non-endemic regions. Whereas the immunological response to Schistosoma infection is well characterised, alterations in inflammatory markers and coagulation in response to acute infection are poorly understood.

Methods

Here we report the clinical, laboratory and radiological characteristics of three returning travellers with Katayama fever. Inflammatory markers and coagulation status were assessed repeatedly during follow-up to characterise the host response to infection. Radiographic findings were correlated with clinical and laboratory markers.

Results

Clinical symptoms were suggestive of a significant inflammatory response in all patients including high fever (>39°C), cough, and general malaise. Classical inflammatory markers including blood sedimentation rate, C-reactive protein, and serum amyloid A were only moderately elevated. Marked eosinophilia (33–42% of white blood cells) was observed and persisted despite anti-inflammatory and anthelminthic treatment for up to 32 weeks. Analysis of blood coagulation markers indicated increased coagulability reflected by elevated D-dimer values (0.57–1.17 μg/ml) and high thrombin generating potentials (peak thrombin activity: 311–384 nM). One patient showed particularly high levels of microparticle-associated tissue factor activity at initial presentation (1.64 pg/ml). Multiple pulmonary and hepatic opacities demonstrated by computed tomography (CT) scanning were associated with raised inflammatory markers in one patient.

Conclusions

The characterisation of the inflammatory response, blood coagulation parameters and radiological findings in three patients adds to our current understanding of Katayama fever and serves as a starting point for further systematic investigations of the pathophysiology of this acute helminthic infection.

【 授权许可】

   
2014 Lagler et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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