Determinants of prescribed drug use among pregnant women in Bahir Dar city administration, Northwest Ethiopia: a cross sectional study

BMC Pregnancy and Childbirth

Gedefaw Abeje¹  Belaynew Wasie¹  Chanie Admasie² 

[1] School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia;Ethiopian Red Cross Society, Essential drug Program, Bahir Dar, Ethiopia

关键词: Bahir Dar city;    Drug use;    Prescription;    Pregnancy;   

Others  :  1125467
DOI  :  10.1186/1471-2393-14-325

 received in 2014-02-14, accepted in 2014-09-16,  发布年份 2014

【 摘 要 】

Background

Drug use during pregnancy may be dangerous to the fetus. There is high consumption of prescribed drugs among pregnant women. This condition may be much higher in developing countries. There is no sufficient evidence on prescribed drug use among pregnant women in Bahir Dar town. The aim of this study was to assess the level of prescribed drug use and associated factors among pregnant women attending antenatal care (ANC) service at government health centers in Bahir Dar city administration.

Methods

Institution based cross sectional study was used. Data were collected from randomly selected 510 pregnant women. Data were analyzed using SPSS version 16.0. Back ward stepwise logistic regression model was used and p-values <0.05 were considered statistically significant.

Result

A total of 510 pregnant women were included in the study of which 88.4% were prescribed at least one drug during pregnancy. Nearly 11% of the pregnant women were prescribed with drugs from category D or X of the US-FDA risk classification.

Prescribed drug use among pregnant women was more likely when the pregnancy is wanted, (AOR = 2.4, 95% CI: 1.3 - 4.6), if the mother had maternal illness (AOR = 8.5, 95% CI: 5.4-13.4), when the educational level of ANC provider is diploma (AOR = 2.7, 95% CI: 1.5-4.7) and when number of pregnancies is more (AOR =2.1, 95% CI: 1.3-3.3).

Conclusion

Prescribed drug use including those with potential harm to the fetus during pregnancy was very high in Bahir Dar city administration. Prescribed drug use is more when the woman had illness, when the woman was multi gravida and when the educational level of ANC provider was low (diploma). It is important to upgrade providers’ educational level and institute prevention of diseases like malaria to reduce the level of prescribed drug use during pregnancy.

【 授权许可】

   
2014 Admasie et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

【 参考文献 】

• [1]Koren G, Pastuszak A, Ito S: Drugs in pregnancy. N Engl J Med 1998, 338(16):1128-1137.
• [2]Bánhidy F, Lowry R, Czeizel A: Risk and benefit of drug use during pregnancy. Int J Med Sci 2005, 2(3):100-106.
• [3]Malm H, Martikainen J, Klaukka T, Neuvonen P, Study FR-B: Prescription drug during pregnancy and lactation: a Finnish register-based study. Eur J Clin Pharmacol 2003, 59(2):127-133.
• [4]Das B, Sarkar C, Datta A, Bohra S: A study of drug use during pregnancy in a teaching hospital in western Nepal. Pharmacoepidemiol Drug Saf 2003, 35:194-201.
• [5]Lee E, Maneno MK, Smith L, Weiss SR, Zuckerman IH, Wutoh AK, Xue Z: National patterns of medication use during Pregnancy. Pharmacoepidemiol Drug Saf 2006, 3:537-542.
• [6]WHO, University of Amsterdam, Royal tropical institute: How to investigate the use of medicines by consumers. 2004. Available at: http://www.who.int/drugresistance/Manual1_HowtoInvestigate.pdf webcite Date Accessed: January12, 2013
• [7]EzeUI EAE, Oparah AC, Enato E: Assessment of prescription profile of pregnant women visiting antenatal clinics. Pharm Pract 2007, 5(3):135-139. Available at: http://www.pharmacypractice.org/journal/index.php/pp/article/view/250 webcite
• [8]Kebede B, Gedif T, Getachew A: Assessment of drug use among pregnant women in Addis Ababa, Ethiopia. Pharmacoepidemiol Drug Saf 2008, 18:1-12.
• [9]Central statistical Agency (CSA): The 2007 population and housing Census of Ethiopia: Statistical summary report at national level. Addis Ababa: United Nations Population Fund (UNFPA); 2008.
• [10]Sanders DH: Statistics: A first course. 5th edition. New York: McGraw Hill; 1995:260-261.
• [11]Nordeng H, Eskild A, Nesheim BI, Jacobsen G: Drug use in pregnancy among parous Scandinavian women. Norwegian J Epidemiol 2001, 11:97-103.
• [12]Irl C, Kipferler P, Hasford J: Drug use assessment and risk evaluation in pregnancy. Pharmacoepidemiol Drug Saf 1997, 6:S37-S42.
• [13]Gomes KR, Moron AF, Silva RD, Siqueira A: Prevalence of Medicines during Pregnancy and its Relationship to Maternal Factors. Rev de Saude Publica 1999, 33(30):246-254.
• [14]Rohra DK, Das N, Azam SI, Solangi AN, Memon Z, Shaikh AM, Khan NH: Drug prescribing patterns during pregnancy in the tertiary care hospitals of Pakistan: a cross-sectional study. BMC Pregnancy Childbirth 2008, 8:24. BioMed Central Full Text
• [15]Andrade ES, Raebel MA, Morse AN, Davis RL, Chan KA, Finkelstein JA, Fortman K, McPhillips H, Roblin D, Smith DH, Yood MU, Platt R, Gurwitz JH: Use of prescription medications with a potential for fetal harm among pregnant women. Pharmacoepidemiol Drug Saf 2006, 15:546-554.
• [16]Kazeem AO, Ireti OA, Idowu OS, Ibrahim A, Olayinka O: Medicines used in Pregnancy, childbirth and lactation in a teaching Hospital in Lagos, Nigeria. Sri Lanka. J Obstet Gynaecol 2012, 34:84-98.
• [17]Kwok-Yin L, Yuk-Ping L, Ho-Yee C, Chin-Peng L, Mary HY: Are herbal medicinal plants less teratogenic than Western pharmaceutical products? Acta Pharmacol Sin 2002, 23(12):1169-1172.