An adult patient with Henoch-Schönlein purpura and non-occlusive mesenteric ischemia

BMC Research Notes

Kazuo Akiyama²  Tamiko Takemura⁴  Hiroyuki Mitomi³  Takahiro Tsuburai²  Satoshi Sugano⁵  Tomoko Omori¹  Masakazu Takigawa¹  Naomi Tsurikisawa²  Chiyako Oshikata² 

[1] Department of Radiology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, Kanagawa 252-0392, Japan;Department of Allergy and Respirology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, Kanagawa 252-0392, Japan;Department of Human Pathology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan;Department of Pathology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan;Department of Gastroenterology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, Kanagawa 252-0392, Japan

关键词: Small vessel vasculitis;    Non-occlusive mesenteric ischemia;    Intervention;    Henoch-Schönlein purpura;   

Others  :  1144929
DOI  :  10.1186/1756-0500-6-26

 received in 2012-08-17, accepted in 2013-01-18,  发布年份 2013

【 摘 要 】

Background

Onset of Henoch-Schönlein purpura (HSP) in middle age is uncommon, and adults with renal or gastrointestinal involvement present with more severe disease than do similar pediatric patients.

Case presentation

We present the case of a 69-year-old male with HSP who, after treatment with steroids, cyclophosphamide, and continuous intravenous prostaglandin E1 (PGE1), died as a result of severe gastrointestinal involvement with non-occlusive mesenteric ischemia (NOMI). Vascular narrowing associated with the NOMI improved after catheter injection of PGE1 and prednisolone, but the patient died of bleeding from an exposed small vessel. At autopsy there was no active vasculitis in the jejunal submucosa.

Conclusion

Treatment with PGE1 and prednisolone might improve small-vessel vasculitis associated with NOMI.

【 授权许可】

   
2013 Oshikata et al.; licensee BioMed Central Ltd.

【 图 表 】

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