Asymmetry, sex differences and age-related changes in the white matter in the healthy elderly: a tract-based study

BMC Research Notes

Toshifumi Kishimoto¹  Kimihiko Kichikawa²  Masami Fukusumi¹  Toshiaki Taoka²  Kuniaki Kiuchi¹  Masayuki Morikawa³  Soichiro Kitamura¹ 

[1] Department of Psychiatry, Nara Medical University, Kashihara, Japan;Department of Radiology, Nara Medical University, Kashihara, Japan;Sakai City Mental Health Center, Sakai, Japan

关键词: white matter;    aging;    sex difference;    asymmetry;    tractography;    diffusion tensor imaging;   

Others  :  1167138
DOI  :  10.1186/1756-0500-4-378

 received in 2011-07-01, accepted in 2011-10-04,  发布年份 2011

【 摘 要 】

Background

Hemispherical asymmetry, sex differences and age-related changes have been reported for the human brain. Meanwhile it was still unclear the presence of the asymmetry or sex differences in the human brain occurred whether as a normal development or as consequences of any pathological changes. The aim of this study was to investigate hemispherical asymmetry, sex differences and age-related changes by using a tract-based analysis in the nerve bundles.

Methods

40 healthy elderly subjects underwent magnetic resonance diffusion tensor imaging, and we calculated fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values along the major white matter bundles.

Results

We identified hemispherical asymmetry in the ADC values for the cingulate fasciculus in the total subject set and in males, and a sex difference in the FA values for the right uncinate fasciculus. For age-related changes, we demonstrated a significant increase in ADC values with advancing age in the right cingulum, left temporal white matter, and a significant decrease in FA values in the right superior longitudinal fasciculus.

Conclusion

In this study, we found hemispherical asymmetry, sex differences and age-related changes in particular regions of the white matter in the healthy elderly. Our results suggest considering these differences can be important in imaging studies.

【 授权许可】

   
2010 Kitamura et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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