Are selected IL-1 polymorphisms and selected subgingival microorganisms significantly associated to periodontitis in type 2 diabetes patients? a clinical study

BMC Oral Health

Anton Sculean¹  Sebastian Noe³  Julia Karl⁴  Marco Kesting⁴  Stefan Wagenpfeil²  Thomas Mücke⁴  Herbert Deppe⁴ 

[1] Department of Periodontology, University of Berne, Berne, Switzerland;Institute for Medical Biometry, Epidemiology and Medical Informatics, University of Saarland, Homburg Saar, Germany;Department of Internal Medical Department II, Technical University of Munich, Klinikum rechts der Isar, Homburg Saar, Germany;Department of Oral and Maxillofacial Surgery, Technical University of Munich, Klinikum rechts der Isar, Ismaninger Strasse 22, Homburg Saar D-81675 Munich, Germany

关键词: Microbiology;    IL1A;    Metabolic control;    Periodontitis;    Diabetes;   

Others  :  1233001
DOI  :  10.1186/s12903-015-0132-5

 received in 2015-06-26, accepted in 2015-11-06,  发布年份 2015

【 摘 要 】

Background

We evaluated the periodontal conditions in patients with type 2 diabetes mellitus compared to metabolically healthy controls, and determined whether periodontal interleukin genotypes and microorganisms differed between participants with and without type 2 diabetes mellitus.

Methods

From April 2011 to July 2012, we prospectively enrolled healthy controls and patients with type 2 diabetes mellitus. Evaluation included assessment of medical and periodontal findings. We also recorded the presence of several interleukin gene variants and specific microorganisms, both available through commercially available diagnostic kits. Statistical significance was tested by the chi-square test and student’s t-test.

Results

We enrolled 52 patients with type 2 diabetes mellitus and 52 healthy controls. Compared with controls, periodontal disease was significantly more severe in patients with type 2 diabetes mellitus for the following: plaque index, bleeding on probing, pocket probing depth, clinical attachment loss, severe periodontal destruction (i.e., clinical attachment loss ≥ 5 mm), and number of teeth. However, statistical analysis failed to detect significant differences with respect to the periodontal-related interleukin genotypes (p ≥ 0.58) or the selected oral microbiota (p ≥ 0.15).

Conclusion

Based on these results, it may be assumed that chronic periodontitis in patients with type 2 diabetes mellitus is most strongly associated with inadequate oral hygiene. Periodontal interleukin genotypes and differences in oral microbiota seem to play a subordinate role.

【 授权许可】

   
2015 Deppe et al.

【 图 表 】

Fig. 1.

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