Caffeine administration does not alter salivary α-amylase activity in young male daily caffeine consumers

BMC Research Notes

Michael Schoelles⁵  Urs M Nater⁴  Frank E Ritter³  Jeanette M Bennett¹  Courtney A Whetzel¹  Laura Cousino Klein² 

[1]Department of Biobehavioral Health & Penn State Institute of the Neurosciences, The Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, USA

[2]Penn State Institute of the Neurosciences, Pennsylvania State University, University Park, PA, USA

[3]College of Information Sciences and Technology, Pennsylvania State University, University Park, PA, USA

[4]Department of Psychology, University of Marburg, Marburg, Germany

[5]Cognitive Science Department, Rensselaer Polytechnic Institute, Troy, NY, USA

关键词: Heart rate;    Blood pressure;    Cortisol;    Caffeine;    Salivary alpha-amylase;   

Others  :  1134866
DOI  :  10.1186/1756-0500-7-30

 received in 2013-07-31, accepted in 2014-01-02,  发布年份 2014

【 摘 要 】

Background

To follow up on a recent report from our lab [Hum Psychopharmacol 25:359–367, 2010.] we examined the effects of caffeine on salivary α-amylase (sAA) activity in response to an engaging, non-stressful task in healthy young males (age 18–30 yrs) who consumed caffeine on a daily basis. Using a placebo-controlled, double-blind, between-subjects design, 45 men received either placebo, 200 mg or 400 mg of caffeine (Vivarin®). Participants then rested for 20 minutes, and performed a 20-minute computerized air traffic controller-like task that was cognitively engaging but not stressful. Saliva samples (assayed for sAA and cortisol), blood pressure, and heart rate were taken before (baseline) and 15 minutes after the computerized task.

Results

Systolic and diastolic blood pressure and sAA activity increased across the laboratory session (F’s > 9.20, p’s < 0.05); salivary cortisol levels decreased (F = 16.17, p < 0.05). There were no main effects for caffeine administration on sAA, salivary cortisol, or cardiovascular measures, and caffeine did not interact with the task to alter these measures.

Conclusions

Laboratory administered caffeine does not alter sAA activity, even when sAA activity is stimulated by participating in a cognitively engaging task. These data demonstrate that caffeine administration does not affect sAA activity, at least in healthy young men who regularly consume caffeine. Results support recent findings that basal caffeine levels in habitual caffeine users are not associated with basal sAA activity and that daily caffeine intake and diurnal sAA activity are not related.

【 授权许可】

   
2014 Klein et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Klein LC, Bennett JM, Whetzel CA, Granger DA, Ritter FE: Effects of caffeine and stress on salivary α-amylase in young men. Hum Psychopharmacol 2010, 25:359-367.
• [2]Freedman ND, Park Y, Abnet CC, Hollenbeck AR, Sinha R: Association of coffee drinking with total and cause-specific mortality. N Engl J Med 2012, 2012(366):1891-1904.
• [3]Rodrigues IM, Klein LC: Boiled or filtered coffee? Effects of coffee and caffeine on cholesterol, fibrinogen, and C-reactive protein. Toxicol Rev 2006, 25:55-69.
• [4]James JE: Understanding Caffeine: A Biobehavioral Analysis. Thousand Oaks, CA: Sage Publications; 1997.
• [5]Mort JR, Kruse HR: Timing of blood pressure measurement related to caffeine consumption. Ann Pharmacother 2008, 42:105-110.
• [6]Scannapieco FA, Torres G, Levine ML: Salivary alpha-amylase: role in dental plaque and caries formation. Crit Rev Oral Biol Med 1993, 4:301-307.
• [7]Baum BJ: Principles of saliva secretion. Ann New York Acad Sci 1993, 694:17-23.
• [8]Granger DA, Kivlighan KT, El-Sheikh M, Gordis E, Stroud LR: Salivary alpha-amylase in biobehavioral research: recent developments and applications. Ann New York Acad Sci 2007, 1098:122-144.
• [9]Nater UM, Rohleder N: Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: current state of research. Psychoneuroendocrinology 2009, 34:486-496.
• [10]Rohleder N, Nater UM: Determinants of salivary α-amylase in humans and methodological considerations. Psychoneuroendocrinology 2009, 34:469-485.
• [11]Bishop NC, Walker GJ, Scanlon GA, Richards S, Rogers E: Salivary IgA responses to prolonged intensive exercise following caffeine ingestion. Med Sci Sports Exerc 2006, 38:513-519.
• [12]Morrison WE, Haas EC, Shaffner DH, Garrett ES, Fackler JC: Noise, stress, and annoyance in a pediatric intensive care unit. Crit Care Med 2003, 31:113-119.
• [13]Nater UM, Rohleder N, Schlotz W, Ehlert U, Kirschbaum C: Determinants of the diurnal course of saliva alpha-amylase. Psychoneuroendocrinology 2007, 32:392-401.
• [14]McLean C, Graham TE: Effects of exercise and thermal stress on caffeine pharmacokinetics in men and eumenorrheic women. J Appl Physiol 2002, 93:1471-1478.
• [15]Childs E, de Wit H: Hormonal, cardiovascular, and subjective responses to acute stress in smokers. Psychopharmacology (Berl) 2009, 203:1-12.
• [16]Abernethy DR, Todd EL: Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptive steroids. Eur J Clin Pharmacol 1985, 28:425-428.
• [17]Centers for Disease Control: Healthy Weight–it’s not a diet, it’s a lifestyle! About BMI for Adults. http://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/index.html webcite
• [18]Radloff LS: The CES-D scale: a self report depression scale for research in the general population. Appl Psychol Meas 1977, 1:385-401.
• [19]Borow KM, Newburger JW: Noninvasive estimation of central aortic pressure using the oscillometric method for analyzing artery pulsatile flow: comparative study of indirect systolic, diastolic, and mean brachial artery pressure with simultaneous direct ascending aortic pressure measurements. Am Heart J 1982, 103:879-886.
• [20]Mueller UK, Wells M, Radevski I, Ouwerkerk J, Tager R, Sliwa K, Sareli P: Repeated versus daytime ambulatory blood pressure measurement in mild, moderate and severe untreated black hypertensive patients. Blood Press Monit 1997, 2:21-25.
• [21]Lane JD, Pieper CF, Phillips-Bute BG, Bryant JE, Kuhn CM: Caffeine affects cardiovascular and neuroendocrine activation at work and home. Psychosom Med 2002, 64:595-603.
• [22]Lieberman HR, Tharion WJ, Shukitt-Hale B, Speckman KL, Tulley R: Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Psychopharmacology (Berl) 2002, 164:250-261.
• [23]Bonati M, Latini R, Galletti F, Young JF, Tognoni G, Garattini S: Caffeine disposition after oral doses. Clin Pharmacol Ther 1982, 32:98-106.
• [24]Liguori A, Huges JR, Grass JA: Absorption and subjective effects of caffeine from coffee, cola and capsules. Pharmacol Biochem Behav 1997, 58:721-726.
• [25]Schoelles MJ, Gray WD: Argus: a suite of tools for research in complex cognition. Behav Res Meth Instrum Comput 2001, 33:130-140.
• [26]Kirschbaum C, Pirke KM, Hellhammer DH: The ‘Trier Social Stress Test’–a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 1993, 28:76-81.
• [27]Granger DA, Kivlighan KT, Blair C, El-Sheikh M, Mize J, Lisonbee JA, Buckhalt JA, Stroud LR, Handwerger K, Schwartz EB: Integrating the measurement of salivary α-amylase into studies of child health, development, and social relationships. J Pers Soc Relat 2006, 23:267-290.
• [28]Ockenfels MC, Porter L, Smyth J, Kirschbaum C, Hellhammer DH, Stone AA: Effect of chronic stress associated with unemployment in salivary cortisol: overall cortisol levels, diurnal rhythm, and acute stress reactivity. Psychosom Med 1995, 57:460-467.
• [29]al’Absi M, Lovallo WR, McKey B, Sung BH, Whitsett TL, Wilson MF: Hypothalamic-pituitary-adrenocortical responses to psychological stress and caffeine in men at high and low risk for hypertension. Psychosom Med 1998, 60:521-527.
• [30]Lovallo WR, al’Absi M, Pincomb GA, Everson SA, Sung BH, Passey RB, Wilson MF: Caffeine and behavioral stress effects on blood pressure in borderline hypertensive Caucasian men. Health Psychol 1996, 15:11-17.
• [31]Bennett JM, Rodrigues IM, Klein LC: Effects of caffeine and stress on biomarkers of cardiovascular disease in healthy men and women with a family history of hypertension. Stress Health 2013, 29:401-409.
• [32]Sudano I, Spieker L, Binggeli C, Ruschitzka F, Lüscher TF, Noll G, Corti R: Coffee blunts mental stress-induced blood pressure increase in habitual but not in nonhabitual coffee drinkers. Hypertension 2005, 46:521-526.