Effects of combined extract of cocoa, coffee, green tea and garcinia on lipid profiles, glycaemic markers and inflammatory responses in hamsters

BMC Complementary and Alternative Medicine

Mei-Chich Hsu³  Chi-Chang Huang²  Wen-Ching Huang¹  Yi-Ming Chen²  Yi-Ju Hsu²  Chih-Wei Chang³ 

[1] Graduate Institute of Athletics and Coaching Science, National Taiwan Sport University, 250, Wen-Hua 1st Rd, Taoyuan 33301, Taiwan;Graduate Institute of Sports Science, National Taiwan Sport University, 250, Wen-Hua 1st Rd, Guishan 33301, Taoyuan, Taiwan;Department of Sports Medicine, Kaohsiung Medical University, 100, Shih-Chuan 1st Rd, Sanmin 80708, Kaohsiung, Taiwan

关键词: HOMA-IR;    Dose-dependent;    Plant;    Polyphenols;    Dyslipidaemia;    Cholesterol;   

Others  :  1222570
DOI  :  10.1186/s12906-015-0806-1

 received in 2015-04-27, accepted in 2015-08-06,  发布年份 2015

【 摘 要 】

Background

Dyslipidaemia is highly associated with cardiovascular and cerebrovascular diseases, which have been ranked second and third place of leading causes of death in Taiwan. Some plant extracts have been proved effective against dyslipidaemia. However, the combination of plant extracts was rarely studied. The purpose of the present study is to understand the beneficial effects of a combined extract (comprising cocoa, coffee, green tea and garcinia; CCGG) on lipid profiles in serum, liver, and faeces as well as glycaemic markers and related proinflammatory cytokines by using an appropriate animal model, the golden Syrian hamster.

Methods

A total of 40 male hamsters were randomly assigned to five groups: (1) vehicle control, (2) high-cholesterol diet control, (3) high-cholesterol diet of 311 mg/kg/d of CCGG, (4) high-cholesterol diet of 622 mg/kg/d of CCGG and (5) high-cholesterol diet of 1555 mg/kg/d of CCGG. At the end of the experiment, blood, tissue and faecal samples were collected for further analysis.

Results

After 6 weeks of treatment, CCGG supplementation significantly reduced serum lipid content (triglycerides, total cholesterol and LDL-C) and hepatic lipid content (triglycerides and cholesterol) with dose-dependent effects. In addition, an increase in excretion of faecal lipids (bile acids) was observed after supplementation. Furthermore, the homeostasis model assessment of insulin resistance (HOMA-IR) index and serum proinflammatory cytokine levels (TNF-α and IL-6) involved in dyslipidaemia was markedly improved. In addition, by monitoring biochemical parameters as well as histopathology of major tissues, no toxicity was observed after the consumption of CCGG.

Conclusion

Dietary CCGG supplementation may exert potential effects on ameliorating hyperlipidaemia, insulin resistance, liver steatosis and related inflammation.

【 授权许可】

   
2015 Chang et al.

【 图 表 】

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