Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report

BMC Research Notes

Yahya Daneshbod⁵  Shahram Paydar⁴  Mohammad Mohammadianpanah³  Reza Vojdani⁶  Babak Bagheri¹  Mahsa Khanlari² 

[1] Institute of Ophthalmology, Dr. Bagheri clinic, Shiraz, Iran;Institute of Hematopathology, Dr Daneshbod Pathology Laboratory, Shiraz, Iran;Institute of Radiation- Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;Institute of Trauma and surgery, Rajaee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;Dr Daneshbod Pathology Laboratory, Dept. of Hematopathology, Shiraz, 7134777118, Iran;Institute of Hematology -Oncology, Nemazee Hospital, Shiraz, Iran

关键词: SOX 11;    14);    t(11;    Mantle cell lymphoma;    Conjunctiva;    Orbit;    Lymphoma;   

Others  :  1165065
DOI  :  10.1186/1756-0500-5-671

 received in 2012-08-04, accepted in 2012-10-15,  发布年份 2012

【 摘 要 】

Background

To describe a rare manifestation of mantle cell lymphoma (MCL) in conjunctiva, with clinical, hisologic, immunohistologic and genetic findings together with review of the Literature.

Case presentation

Most ocular adnexal lymphomas are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT). A few cases of ocular adnexal mantle cell lymphomas have been reported in the literature. We present a case of mantle cell lymphoma presenting as right conjunctival mass of at least three months duration in a 64-year-old man. Histopathologic examination showed a proliferation of monomorphous small-to-medium-sized lymphoid cells with cleaved nuclei in the subconjunctiva. By immunohistochemistry, the infiltrate was positive for CD20, CD5, BCL-2, cyclin D1, and the transcription factor SOX11. Fluorescent in situ hybridization demonstrated the presence of IGH-CCND1 fusion indicating t(11;14).

Conclusion

A rigorous approach to initial diagnosis and staging of small cell lymphomas of the ocular adnexa is needed. The recognition of ocular MCL requires appropriate immunohistochemical staining and/or genetic confirmation to differentiate this rare form of presentation of MCL from other more frequent small cell lymphomas.

【 授权许可】

   
2012 Khanlari et al.; licensee BioMed Central Ltd.

【 图 表 】

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