期刊论文详细信息
BMC Medicine
The physician's unique role in preventing violence: a neglected opportunity?
David T George3  Mohsin Shah1  Karysse Trandem2  John C Umhau3 
[1]Medical College, CMH Lahore Medical College, University of Health Sciences, Abdur Rahman Road, Cantt, Lahore, Punjab, 54000, Pakistan
[2]Department of Obstetrics and Gynecology, Grand Itasca Clinic and Hospital, 1601 Golf Course Road, Grand Rapids, MN 55744, USA
[3]Laboratory of Clinical and Translational Studies, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, Building 10-CRC Hatfield Center, Room 1-5330, Bethesda, MD, 20892-1108, USA
关键词: domestic violence;    treatment;    neurobiology;    prevention;    domestic abuse;    violence;    psychopharmacology;    alcoholism;    aggression;   
Others  :  857281
DOI  :  10.1186/1741-7015-10-146
 received in 2012-07-30, accepted in 2012-11-23,  发布年份 2012
PDF
【 摘 要 】

Background

Episodes of explosive rage and violence comprise a symptom complex which can have a devastating effect on a person's life. In the community this behavior is seen as workplace violence, domestic abuse and road rage, while in the clinical setting, this behavior is rarely mentioned by patients, despite evidence that it can signify an important biological disorder that may afflict more than three percent of the population.

Discussion

Patients are often reluctant to seek help for episodic attacks of rage, especially attacks which are accompanied by physical violence. Although, in the past, clinicians have had few treatment options to offer, recent neuroscience advances have created new possibilities to understand and help patients with this neglected problem. No formal medical guidelines for treating violence exist; however, many patients can be helped by diagnosis, referral and treatment. Treatment can include pharmaceuticals and nutrients, as well as referral for anger management or behavioral therapy.

Summary

The astute clinician has an opportunity to positively impact an important problem through the diagnosis and treatment of patients with symptoms of intermittent explosive disorder.

【 授权许可】

   
2012 Umhau et al; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20140723074139652.pdf 298KB PDF download
【 参考文献 】
  • [1]Siegel A, Victoroff J: Understanding human aggression: new insights from neuroscience. Int J Law Psychiatry 2009, 32:209-215.
  • [2]American Psychiatric Association, Task Force on D-I: Diagnostic and statistical manual of mental disorders: DSM-IV-TR. Arlington, VA: American Psychiatric Publishing, Inc.; 2000.
  • [3]Kessler RC, Coccaro EF, Fava M, Jaeger S, Jin R, Walters E: The prevalence and correlates of DSM-IV intermittent explosive disorder in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2006, 63:669-678.
  • [4]George DT, Anderson P, Nutt D, Linnoila M: Aggressive thoughts and behavior: another symptom of panic disorder? Acta Psychiatr Scand 1989, 79:500-502.
  • [5]George DT, Hibbeln JR, Ragan PW, Umhau JC, Phillips MJ, Doty L, Hommer D, Rawlings RR: Lactate-induced rage and panic in a select group of subjects who perpetrate acts of domestic violence. Biol Psychiatry 2000, 47:804-812.
  • [6]George DT, Phillips MJ, Doty L, Umhau JC, Rawlings RR: A model linking biology, behavior and psychiatric diagnoses in perpetrators of domestic violence. Med Hypotheses 2006, 67:345-353.
  • [7]George DT, Umhau JC, Phillips MJ, Emmela D, Ragan PW, Shoaf SE, Rawlings RR: Serotonin, testosterone and alcohol in the etiology of domestic violence. Psychiatry Res 2001, 104:27-37.
  • [8]George DT, Rawlings RR, Williams WA, Phillips MJ, Fong G, Kerich M, Momenan R, Umhau JC, Hommer D: A select group of perpetrators of domestic violence: evidence of decreased metabolism in the right hypothalamus and reduced relationships between cortical/subcortical brain structures in position emission tomography. Psychiatry Res 2004, 130:11-25.
  • [9]Siever LJ: Neurobiology of aggression and violence. Am J Psychiatry 2008, 165:429-442.
  • [10]Davis M, Rainnie D, Cassell M: Neurotransmission in the rat amygdala related to fear and anxiety. Trends Neurosci 1994, 17:208-214.
  • [11]Davidson RJ, Putnam KM, Larson CL: Dysfunction in the neural circuitry of emotion regulation--a possible prelude to violence. Science 2000, 289:591-594.
  • [12]Bufkin JL, Luttrell VR: Neuroimaging studies of aggressive and violent behavior: current findings and implications for criminology and criminal justice. Trauma Violence Abus 2005, 6:176-191.
  • [13]Garcia R, Vouimba RM, Baudry M, Thompson RF: The amygdala modulates prefrontal cortex activity relative to conditioned fear. Nature 1999, 402:294-296.
  • [14]Eysenck HJ: The origins of violence. J Med Ethics 1979, 5:105-107.
  • [15]Forgays DG, Forgays DK, Spielberger CD: Factor structure of the State-Trait Anger Expression Inventory. J Pers Assess 1997, 69:497-507.
  • [16]Diamond PM, Magaletta PR: The short-form Buss-Perry Aggression Questionnaire (BPAQ-SF): a validation study with federal offenders. Assessment 2006, 13:227-240.
  • [17]Dutton DG: My back pages: reflections on thirty years of domestic violence research. Trauma Violence Abus 2008, 9:131-143.
  • [18]Simon RI, Tardiff K: Textbook of Violence Assessment and Management. Volume 355. Arlington, VA: American Psychiatric Publishing; 2008.
  • [19]Rossi J, Swan MC, Isaacs ED: The violent or agitated patient. Emerg Med Clin North Am 2010, 28:235-256. x
  • [20]Fava M: Psychopharmacologic treatment of pathologic aggression. Psychiatric Clin North Am 1997, 20:427-451.
  • [21]Lane SD, Kjome KL, Moeller FG: Neuropsychiatry of aggression. Neurologic Clin 2011, 29:49-64. vii
  • [22]Mattson M, editor: Neurobiology of aggression: understanding and preventing violence. Totowa, NJ: Humana Press; 2003.
  • [23]Olvera , Rene L: Intermittent explosive disorder: epidemiology, diagnosis and management. CNS drugs 2002, 16:517-526.
  • [24]Potter-Efron RT: Differential diagnosis of physiological, psychiatric and sociocultural conditions associated with aggression and substance abuse. J Chem Dependency Treat 1990, 3:37-59.
  • [25]Schneider LS, Sobin PB: Non-neuroleptic medications in the management of agitation in Alzheimer's disease and other dementia: a selective review. Int J Geriatr Psychiatry 1991, 6:691-708.
  • [26]Lewis DO, Pincus JH: Epilepsy and violence: evidence for a neuropsychotic-aggressive syndrome. J Neuropsychiatry Clin N 1989, 1:413-418.
  • [27]Rosenbaum A, Hoge SK: Head injury and marital aggression. Am J Psychiat 1989, 146:1048-1051.
  • [28]Tardiff K: Concise Guide to Assessment and Management of Violent Patients. Arlington, VA: American Psychiatric Publishing, Inc.; 1996.
  • [29]Tardiff K: Unusual diagnoses among violent patients. Psychiatr Clin North Am 1998, 21:567-576.
  • [30]Chermack ST, Blow FC: Violence among individuals in substance abuse treatment: the role of alcohol and cocaine consumption. Drug Alcohol Depend 2002, 66:29-37.
  • [31]Goedhard LE, Stolker JJ, Heerdink ER, Nijman HL, Olivier B, Egberts TC: Pharmacotherapy for the treatment of aggressive behavior in general adult psychiatry: a systematic review. J Clin Psychiatry 2006, 67:1013-1024.
  • [32]Huband N, Ferriter M, Nathan R, Jones H: Antiepileptics for aggression and associated impulsivity. Cochrane Database Syst Rev 2010, CD003499.
  • [33]Bitter I, Czobor P, Dossenbach M, Volavka J: Effectiveness of clozapine, olanzapine, quetiapine, risperidone, and haloperidol monotherapy in reducing hostile and aggressive behavior in outpatients treated for schizophrenia: a prospective naturalistic study (IC-SOHO). Eur Psychiatry 2005, 20:403-408.
  • [34]McDougle CJ, Stigler KA, Posey DJ: Treatment of aggression in children and adolescents with autism and conduct disorder. J Clin Psychiatry 2003, 64:16.
  • [35]Fleminger S, Greenwood R, Oliver D: Pharmacological management for agitation and aggression in people with acquired brain injury. Cochrane Database Syst Rev 2006, CD003299.
  • [36]Stanford M, Anderson N, Lake S, Baldridge R: Pharmacologic treatment of impulsive aggression with antiepileptic drugs. Curr Treat Options Neurol 2009, 11:383-390.
  • [37]Haspel T: Beta-blockers and the treatment of aggression. Harv Rev Psychiatry 1995, 2:274-281.
  • [38]Mercer D, Douglass AB, Links PS: Meta-analyses of mood stabilizers, antidepressants and antipsychotics in the treatment of borderline personality disorder: effectiveness for depression and anger symptoms. J Pers Disord 2009, 23:156-174.
  • [39]McQuade DV, Barrnett RJ, King BH: Pharmacological intervention in aggression. In Neurobiology of Aggression: Understanding and Preventing Violence. Totawa, NJ: Humana Press, Inc.; 2003:289-313.
  • [40]Comai S, Tau M, Pavlovic Z, Gobbi G: The psychopharmacology of aggressive behavior: a translational approach: part 2: clinical studies using atypical antipsychotics, anticonvulsants, and lithium. J Clin Psychopharmacol 2012, 32:237-260.
  • [41]Barratt ES, Stanford MS, Felthous AR, Kent TA: The effects of phenytoin on impulsive and premeditated aggression: a controlled study. J Clin Psychopharmacol 1997, 17:341-349.
  • [42]Bowden CL, Grunze H, Mullen J, Brecher M, Paulsson B, Jones M, Vagero M, Svensson K: A randomized, double-blind, placebo-controlled efficacy and safety study of quetiapine or lithium as monotherapy for mania in bipolar disorder. J Clin Psychiatry 2005, 66:111-121.
  • [43]Yatham LN, Paulsson B, Mullen J, Vagero AM: Quetiapine versus placebo in combination with lithium or divalproex for the treatment of bipolar mania. J Clin Psychopharmacol 2004, 24:599-606.
  • [44]Campbell M, Adams PB, Small AM, Kafantaris V, Silva RR, Shell J, Perry R, Overall JE: Lithium in hospitalized aggressive children with conduct disorder: a double-blind and placebo-controlled study. J Am Acad Child Adolesc Psychiatry 1995, 34:445-453.
  • [45]Craft M, Ismail IA, Krishnamurti D, Mathews J, Regan A, Seth RV, North PM: Lithium in the treatment of aggression in mentally handicapped patients. A double-blind trial. Br J Psychiatry 1987, 150:685-689.
  • [46]Kafantaris V, Coletti DJ, Dicker R, Padula G, Kane JM: Lithium treatment of acute mania in adolescents: a large open trial. J Am Acad Child Adolesc Psychiatry 2003, 42:1038-1045.
  • [47]Masi G, Milone A, Manfredi A, Pari C, Paziente A, Millepiedi S: Effectiveness of lithium in children and adolescents with conduct disorder: a retrospective naturalistic study. CNS Drugs 2009, 23:59-69.
  • [48]Worrall EP, Moody JP, Naylor GJ: Lithium in non-manic-depressives: antiaggressive effect and red blood cell lithium values. Br J Psychiatry 1975, 126:464-468.
  • [49]Jones RM, Arlidge J, Gillham R, Reagu S, van den Bree M, Taylor PJ: Efficacy of mood stabilisers in the treatment of impulsive or repetitive aggression: systematic review and meta-analysis. Br J Psychiatry 2011, 198:93-98.
  • [50]Sheard MH, Marini JL, Bridges CI, Wagner E: The effect of lithium on impulsive aggressive behavior in man. Am J Psychiatry 1976, 133:1409-1413.
  • [51]Umhau JC, Dauphinais KM: Omega-3 polyunsaturated fatty acids and health. In Low-Cost Approaches to Promote Physical and Mental Health: Theory, Research and Practice. Edited by L'Abate L. New York, NY Springer Publishing; 2007:87-101.
  • [52]Simopoulos AP: Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain. Mol Neurobiol 2011, 44:203-215.
  • [53]Werbach M: Nutritional influences on aggressive behavior. J Orthomol Med 1992, 7:45-51.
  • [54]Harris WS: Expert opinion: omega-3 fatty acids and bleeding-cause for concern? Am J Cardiol 2007, 99:44C-46C.
  • [55]Mozaffarian D, Rimm EB: Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA 2006, 296:1885-1899.
  • [56]Hibbeln JR, Ferguson TA, Blasbalg TL: Omega-3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for intervention. Int Rev Psychiatry 2006, 18:107-118.
  • [57]Freeman MP, Hibbeln JR, Wisner KL, Davis JM, Mischoulon D, Peet M, Keck PE Jr, Marangell LB, Richardson AJ, Lake J, Stoll AL: Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J Clin Psychiatry 2006, 67:1954-1967.
  • [58]Gesch CB, Hammond SM, Hampson SE, Eves A, Crowder MJ: Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners randomised, placebo-controlled trial. Br J Psychiatry 2002, 181:22-28.
  • [59]Zaalberg A, Nijman H, Bulten E, Stroosma L, van der Staak C: Effects of nutritional supplements on aggression, rule-breaking, and psychopathology among young adult prisoners. Aggress Behav 2010, 36:117-126.
  • [60]Schoenthaler SJ, Bier ID: The effect of vitamin-mineral supplementation on juvenile delinquency among American schoolchildren: a randomized, double-blind placebo-controlled trial. J Altern Complement Med 2000, 6:7-17.
  • [61]Murphy CM, Ting LA: Interventions for perpetrators of intimate partner violence: A review of efficacy research and recent trends. Partner Abuse 2010, 1:26-44.
  • [62]Clark DB: Pharmacotherapy for adolescent alcohol use disorder. CNS Drugs 2012, 26:559-569.
  • [63]Williams SH: Medications for treating alcohol dependence. Am Fam Physician 2005, 72:1775-1780.
  • [64]Ernst DB, Pettinati HM, Weiss RD, Donovan DM, Longabaugh R: An intervention for treating alcohol dependence: relating elements of Medical Management to patient outcomes with implications for primary care. Ann Fam Med 2008, 6:435-440.
  • [65]Babcock JC, Green CE, Robie C: Does batterers' treatment work? A meta-analytic review of domestic violence treatment. Clin Psychol Rev 2004, 23:1023-1053.
  • [66]Chemtob CM, Novaco RW, Hamada RS, Gross DM: Cognitive-behavioral treatment for severe anger in posttraumatic stress disorder. J Consult Clin Psychol 1997, 65:184-189.
  • [67]Gondolf EW: Batterer programs. J Interpers Violence 1997, 12:83-98.
  • [68]Lawson DM, Dawson TE, Kieffer KM, Perez LM, Burke J, Kier FJ: An integrated feminist/cognitive-behavioral and psychodynamic group treatment model for women who abuse their partners. Psychol Men Masculinity 2001, 2:86-99.
  • [69]Gondolf EW: A 30-month follow-up of court-referred batterers in four cities. Int J Offender Ther Comp Criminol 2000, 44:111-128.
  • [70]Beck R, Fernandez E: Cognitive-behavioral therapy in the treatment of anger: a meta-analysis. Cogn Ther Res 1998, 22:63-74.
  • [71]Coccaro E: Aggression: Psychiatric Assessment and Treatment. Volume 22. Zug, Switzerland: Informa Healthcare; 2003.
  • [72]Swenson CR, Sanderson C, Dulit RA, Linehan MM: The application of dialectical behavior therapy for patients with borderline personality disorder on inpatient units. Psychiatr Q 2001, 72:307-324.
  • [73]Evershed S, Tennant A, Boomer D, Rees A, Barkham M, Watson A: Practice-based outcomes of dialectical behaviour therapy (DBT) targeting anger and violence, with male forensic patients: a pragmatic and non-contemporaneous comparison. Crim Behav Ment Health 2003, 13:198-213.
  • [74]Maiuro RD, Eberle JA: State standards for domestic violence perpetrator treatment: current status, trends, and recommendations. Violence Vict 2008, 23:133-155.
  • [75]Levesque DA, Ciavatta MM, Castle PH, Prochaska JM, Prochaska JO: Evaluation of a stage-based, computer-tailored adjunct to usual care for domestic violence offenders. Psychol Violence 2012., 1
  • [76]Taft CT, Murphy CM, Elliott JD, Morrel TM: Attendance-enhancing procedures in group counseling for domestic abusers. J Couns Psychol 2001, 48:51-60.
  • [77]Horvath AO, Symonds BD: Relation between working alliance and outcome in psychotherapy: a meta-analysis. J Couns Psychol 1991, 38:139149.
  • [78]Stone AA: The Tarasoff decisions: suing psychotherapists to safeguard society. Harv Law Rev 1976, 358-378.
  • [79]Walcott DM, Cerundolo P, Beck JC: Current analysis of the Tarasoff duty: an evolution towards the limitation of the duty to protect. Behav Sci Law 2001, 19:325-43.
  • [80]Kaur G, Herbert L: Recognizing and intervening in intimate partner violence. Cleve Clin J Med 2005, 72:406-409.
  • [81]Brown JL: Physicians have ethical, legal obligation to report child abuse. AAP News 2012, 33:20-20.
  • [82]Houry D, Sachs CJ, Feldhaus KM, Linden J: Violence-inflicted injuries: reporting laws in the fifty states. Ann Emerg Med 2002, 39:56-60.
  • [83]Geiderman J: Mandatory and permissive reporting laws: conflicts in patient confidentiality, autonomy, and the duty to report. In Ethical Problems in Emergency Medicine: a Discussion-based Review. 1st edition. Edited by Jesus J, Rosen P, Adams J, Derse AR, Grossman SA, Wolfe R. Hoboken, NJ: Wiley-Blackwell; 2012:271-285.
  • [84]Felthous AR: The clinician's duty to protect third parties. Psychiatr Clin North Am 1999, 22:49-60.
  • [85]Beck JC: Legal and ethical duties of the clinician treating a patient who is liable to be impulsively violent. Behav Sci Law 1998, 16:375-89.
  • [86]Yudofsky S, Stevens L, Silver J, Barsa J, Williams D: Propranolol in the treatment of rage and violent behavior associated with Korsakoff's psychosis. Am J Psychiatry 1984, 141:114-115.
  • [87]Látalová K: Bipolar disorder and aggression. Int J Clin Pract 2009, 63:889-899.
  • [88]Boles SM, Miotto K: Substance abuse and violence: a review of the literature. Aggress Violent Behav 2003, 8:155-174.
  • [89]Tuninger EE, Levander S, Bernce R, Johansson G: Criminality and aggression among psychotic in-patients: frequency and clinical correlates. Acta Psychiatr Scand 2001, 103:294-300.
  • [90]d'Orbán PT, Dalton J: Violent crime and the menstrual cycle. Psychol Med 1980, 10:353-359.
  • [91]Barlow DH: Anxiety and its Disorders. In The Nature and Treatment of Anxiety and Panic. New York, NY: The Guilford Press; 2004.
  • [92]Kernberg OF: Aggression in Personality Disorders and Perversions. New Haven, CT: Yale University Press; 1995.
  • [93]Loney J: Hyperactivity and aggression in the diagnosis of attention deficit disorder. In Advances in clinical child psychology. Volume 10. Edited by Lahey BB, Kazdin AE. New York, NY: Plenum Press; 1987::99-135.
  • [94]Feldbau-Kohn S, Heyman RE, O'Leary KD: Major depressive disorder and depressive symptomatology as predictors of husband to wife physical aggression. Violence Vict 1998, 13:347-360.
  • [95]Villano JL, Mlinarevich N, Watson KS, Engelhard HH, Anderson-Shaw L: Aggression in a patient with primary brain tumor: ethical implications for best management. J Neuro-Oncol 2009, 94:293-296.
  • [96]Dickson DW, Davies P, Mayeux R, Crystal H, Horoupian DS, Thompson A, Goldman JE: Diffuse Lewy body disease. Acta neuropathologica 1987, 75:8-15.
  • [97]Benedict RH, Shapiro A, Priore R, Miller C, Munschauer F, Jacobs L: Neuropsychological counseling improves social behavior in cognitively-impaired multiple sclerosis patients. Mult Scler 2000, 6:391-396.
  • [98]Kito Y, Kazui H, Kubo Y, Yoshida T, Takaya M, Wada T, Nomura K, Hashimoto M, Ohkawa S, Miyake H: Neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus. Behav Neurol 2009, 21:165-174.
  • [99]Rosenblatt A, Leroi I: Neuropsychiatry of Huntington's disease and other basal ganglia disorders. Psychosomatics 2000, 41:24-30.
  • [100]Orengo CA, Khan J, Kunik ME, Snow AL, Morgan R, Steele A, Cully JA, Graham DP: Aggression in individuals newly diagnosed with dementia. Am J Alzheimers Dis Other Demen 2008, 23:227-232.
  • [101]Golden CJ, Jackson ML, Peterson-Rohne A, Gontkovsky ST: Neuropsychological correlates of violence and aggression: A review of the clinical literature. Aggress Violent Beh 1996, 1:3-25.
  • [102]Rayel MG, Land WB, Gutheil TG: Dementia as a risk factor for homicide. J Forensic Sci 1999, 44:565-567.
  • [103]Hector M, Burton JR: What are the psychiatric manifestations of vitamin B12 deficiency? J Am Geriatr Soc 1988, 36:1105-1112.
  • [104]Lonsdale D, Shamberger RJ: Red cell transketolase as an indicator of nutritional deficiency. Am J Clin Nutr 1980, 33:205-211.
  • [105]Werbach M: Nutritional influences on aggressive behavior. J Orthomol Med 1992, 7:45-51.
  • [106]Liu J, Raine A: The effect of childhood malnutrition on externalizing behavior. Curr Opin Pediatr 2006, 18:565-570.
  • [107]Schrauzer GN, Shrestha KP: Lithium in drinking water and the incidences of crimes, suicides, and arrests related to drug addictions. Biol Trace Elem Res 1990, 25:105-113.
  • [108]Rasmussen HH, Mortensen PB, Jensen IW: Depression and magnesium deficiency. Int J Psychiatry Med 1989, 19:57-63.
  • [109]Branchey L, Branchey M, Shaw S, Lieber CS: Depression, suicide, and aggression in alcoholics and their relationship to plasma amino acids. Psychiatry Res 1984, 12:219-226.
  • [110]Giancola PR, Corman MD: Alcohol and aggression: a test of the attention-allocation model. Psychol Sci 2007, 18:649-655.
  • [111]Licata A, Taylor S, Berman M, Cranston J: Effects of cocaine on human aggression. Pharmacol Biochem Behav 1993, 45:549-552.
  • [112]Gottschalk LA, Rebello T, Buchsbaum MS, Tucker HG, Hodges EL: Abnormalities in hair trace elements as indicators of aberrant behavior. Compr Psychiatry 1991, 32:229-237.
  • [113]Singh S, Sharma N: Neurological syndromes following organophosphate poisoning. Neurol India 2000, 48:308-313.
  • [114]Henry J: Drug overdose, drugs of abuse and hypermetabolism. In Hyperthermic and Hypermetabolic Disorders: Exertional Heat-stroke, Malignant Hyperthermia and Related Syndromes. Edited by Hopkins PM, Ellis FR. Cambridge, UK: Press Syndicate of the University of Cambridge; 1996:239-258.
  • [115]Blacker K: Aggression and the chronic use of LSD. J Psychoactive Drugs 1970, 3:32-37.
  • [116]Gerra G, Zaimovic A, Raggi MA, Giusti F, Delsignore R, Bertacca S, Brambilla F: Aggressive responding of male heroin addicts under methadone treatment: psychometric and neuroendocrine correlates. Drug Alcohol Depend 2001, 65:85-95.
  • [117]Anderson PD, Bokor G: Forensic Aspects of Drug-Induced Violence. Journal of Pharmacy Practice 2012, 25:41-49.
  • [118]DiMascio A: The effects of benzodiazepines on aggression: reduced or increased? Psychopharmacology 1973, 30:95-102.
  • [119]Williams ER, Shepherd SM: Medical clearance of psychiatric patients. Emerg Med Clin North Am 2000, 18:185-198.
  • [120]Benton D, Kumari N, Brain PF: Mild hypoglycaemia and questionnaire measures of aggression. Biol Psychol 1982, 14:129-135.
  • [121]Rahman T, Hodgson H: Clinical management of acute hepatic failure. Intensive Care Med 2001, 27:467-476.
  • [122]Gupta N, Midha P, Singh G: Psychiatric aspects of endocrine disorders. In Recent Advances Pediatrics: Pediatric Endocrinology. Special Volume 13. Edited by Gupte S. New Delhi: Jaypee Brothers Medical Publishers; 2004:308.
  • [123]Trafford PA: Homicide in acute porphyria. Forensic Sci 1976, 7:113-120.
  • [124]Berkowitz L: Pain and aggression: some findings and implications. Motivation Emotion 1993, 17:277-293.
  • [125]Soldatos C, Kales A: Sleep disorders: research in psychopathology and its practical implications. Acta Psychiatr Scand 1982, 65:381-387.
  • [126]Arai A, Ishii T, Yasui T, Takahashi A, Ishigooka J, Murakaki M: A case of iron deficiency anemia with delirium. Kanagawaken Seishin Igakkaishi 1998, 48:31-36.
  • [127]Simpson TL, Saxon AJ, Meredith CW, Malte CA, McBride B, Ferguson LC, Gross CA, Hart KL, Raskind M: A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence. Alcohol Clin Exp Res 2009, 33:255-263.
  • [128]Kaplan BJ, Crawford SG, Gardner B, Farrelly G: Treatment of mood lability and explosive rage with minerals and vitamins: two case studies in children. J Child Adolesc Psychopharmacol 2002, 12:205-219.
  • [129]Yudofsky S, Williams D, Gorman J: Propranolol in the treatment of rage and violent behavior in patients with chronic brain syndromes. Am J Psychiatry 1981, 138:218-220.
  • [130]Stanford MS, Houston RJ, Mathias CW, Greve KW, Villemarette-Pittman NR, Adams D: A double-blind placebo-controlled crossover study of phenytoin in individuals with impulsive aggression. Psychiatry Res 2001, 103:193-203.
  • [131]Coccaro EF, Kavoussi RJ: Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch Gen Psychiatry 1997, 54:10811088.
  • [132]George DT, Phillips MJ, Lifshitz M, Lionetti TA, Spero DE, Ghassemzedeh N, Doty L, Umhau JC, Rawlings RR: Fluoxetine treatment of alcoholic perpetrators of domestic violence: a 12-week, double-blind, randomized, placebo-controlled intervention study. J Clin Psychiatry 2011, 72:60-65.
  • [133]Sultzer DL, Gray KF, Gunay I, Berisford MA, Mahler ME: A double-blind comparison of trazodone and haloperidol for treatment of agitation in patients with dementia. Am J Geriatr Psychiatry 1997, 5:60-69.
  • [134]Buckley PF: The role of typical and atypical antipsychotic medications in the management of agitation and aggression. J Clin Psychiatry 1999, 60(suppl 10):52-60.
  文献评价指标  
  下载次数:7次 浏览次数:20次