Association between tooth loss and orodigestive cancer mortality in an 80-year-old community-dwelling Japanese population: a 12-year prospective study

BMC Public Health

Naoko Shimada⁴  Akira Sogame²  Tomoko Hamasaki⁵  Shuji Awano³  Inho Soh³  Akihiro Yoshida³  Yutaka Takata¹  Toshihiro Ansai³ 

[1] Division of General Internal Medicine, Kyushu Dental University, Kitakyushu, Japan;Munakata and Onga Office for Health, Human Services and Environmental Issues, Munakata, Japan;Division of Community Oral Health Development, Kyushu Dental University, Kitakyushu, Japan;Kitakyushu Public Health and Welfare Bureau, Kitakyushu, Japan;Division of Home Economics, Kyushu Women University, Kitakyushu, Japan

关键词: Tooth loss;    Gastrointestinal cancer;    Dental care;   

Others  :  1161828
DOI  :  10.1186/1471-2458-13-814

 received in 2013-05-08, accepted in 2013-09-05,  发布年份 2013

【 摘 要 】

Background

A growing body of evidence has indicated a possible association between oral and gastrointestinal (orodigestive) cancers and periodontal disease or tooth loss. However, the evidence remains contradictory. This study investigated whether tooth loss, which is indicative of poor oral health and a potential source of oral infections, is associated with death from orodigestive cancer.

Methods

The study included 656 subjects in Fukuoka prefecture, Japan, who were 80 years old at baseline in 1998. All subjects underwent oral clinical examination and answered a questionnaire to determine their background characteristics. Cause of death over the 12-year follow-up was recorded from the registers at the Public Health Centers and classified according to the WHO International Classification of Diseases. Statistical analysis of associations was performed using Kaplan-Meier and Cox multivariate regression analyses.

Results

A significant association was observed between tooth loss (continuous variable) and cancer death (hazard ratio (HR): 1.03, 95% confidence interval (CI): 1.00–1.07), after adjustment for potential confounders, including sex and smoking status. However, that association became insignificant in the fully adjusted model. On the other hand, tooth loss was significantly associated with orodigestive cancer (HR: 1.06, 95% CI: 1.01–1.13), even in the fully adjusted model including place of residence as a part of socioeconomic status.

Conclusions

This study provides the first evidence in a prospective study in a Japanese population that tooth loss is associated with increased orodigestive cancer mortality, although the causality remains unclear.

【 授权许可】

   
2013 Ansai et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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