Computational developments in microRNA-regulated protein-protein interactions

BMC Systems Biology

Yi-Ping Phoebe Chen¹  Wei Zhu¹ 

[1] Department of Computer Science and Computer Engineering, La Trobe University, Melbourne, Australia

关键词: Protein-protein interaction;    Regulation;    miRNA;   

Others  :  1141454
DOI  :  10.1186/1752-0509-8-14

 received in 2013-01-03, accepted in 2014-01-20,  发布年份 2014

【 摘 要 】

Protein-protein interaction (PPI) is one of the most important functional components of a living cell. Recently, researchers have been interested in investigating the correlation between PPI and microRNA, which has been found to be a regulator at the post-transcriptional level. Studies on miRNA-regulated PPI networks will not only facilitate an understanding of the fine tuning role that miRNAs play in PPI networks, but will also provide potential candidates for tumor diagnosis. This review describes basic studies on the miRNA-regulated PPI network in the way of bioinformatics which includes constructing a miRNA-target protein network, describing the features of miRNA-regulated PPI networks and overviewing previous findings based on analysing miRNA-regulated PPI network features.

【 授权许可】

   
2014 Zhu and Chen; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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