Wasting among Uganda men with pulmonary tuberculosis is associated with linear regain in lean tissue mass during and after treatment in contrast to women with wasting who regain fat tissue mass: prospective cohort study

BMC Infectious Diseases

Christopher C Whalen²  Harriet K Mayanja³  W Henry Boom⁴  Roy Mugerwa³  Catherine M Stein¹  Isabel M Parraga⁶  Daniel J Tisch¹  Mary Nsereko⁵  Alphonse Okwera⁵  Sarah Zalwango⁵  LaShaunda Malone⁴  Ezekiel Mupere⁵ 

[1] Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, USA;Department of Epidemiology & Biostatistics College of Public Health, University of Georgia Athens, Athens, USA;Department of Internal Medicine College of Health Sciences, Makerere University, Kampala, Uganda;Tuberculosis Research Unit, Case Western Reserve University, Cleveland, USA;Uganda-Case Western Reserve Research Collaboration, Kampala, Uganda;Department of Nutrition, Case Western Reserve University, Cleveland, USA

关键词: Gender;    Body mass index;    Fat mass index;    Lean tissue mass index;    Wasting;    HIV;    Tuberculosis;   

Others  :  1135001
DOI  :  10.1186/1471-2334-14-24

 received in 2013-06-19, accepted in 2014-01-07,  发布年份 2014

【 摘 要 】

Background

Nutritional changes during and after tuberculosis treatment have not been well described. We therefore determined the effect of wasting on rate of mean change in lean tissue and fat mass as measured by bioelectrical impedance analysis (BIA), and mean change in body mass index (BMI) during and after tuberculosis treatment.

Methods

In a prospective cohort study of 717 adult patients, BMI and height-normalized indices of lean tissue (LMI) and fat mass (FMI) as measured by BIA were assessed at baseline, 3, 12, and 24 months.

Results

Men with wasting at baseline regained LMI at a greater rate than FMI (4.55 kg/m² (95% confidence interval (CI): 1.26, 7.83 versus 3.16 (95% CI: 0.80, 5.52)) per month, respectively during initial tuberculosis therapy. In contrast, women with wasting regained FMI at greater rate than LMI (3.55 kg/m² (95% CI: 0.40, 6.70) versus 2.07 (95% CI: -0.74, 4.88)), respectively. Men with wasting regained BMI at a rate of 6.45 kg/m² (95% CI: 3.02, 9.87) in the first three months whereas women, had a rate of 3.30 kg/m² (95% CI: -0.11, 6.72). There were minimal changes in body composition after month 3 and during months 12 to 24.

Conclusion

Wasted tuberculosis patients regain weight with treatment but the type of gain differs by gender and patients may remain underweight after the initial phase of treatment.

【 授权许可】

   
2014 Mupere et al.; licensee BioMed Central Ltd.

【 图 表 】

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