Reduced duration mismatch negativity in adolescents with psychotic symptoms: further evidence for mismatch negativity as a possible biomarker for vulnerability to psychosis

BMC Psychiatry

Richard AP Roche²  Mary Cannon³  Patrick S Markey¹  Deirdre Twomey¹  Ian Kelleher¹  Caroline Rawdon²  Jennifer R Murphy¹ 

[1] Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland;Department of Psychology, National University of Ireland, Maynooth, Co, Kildare, Ireland;Department of Psychiatry, Education and Research Centre, Beaumont Hospital, Dublin, Ireland

关键词: Psychosis;    Schizophrenia;    Psychotic symptoms;    Mismatch negativity;    MMN;   

Others  :  1124148
DOI  :  10.1186/1471-244X-13-45

 received in 2012-10-01, accepted in 2013-01-24,  发布年份 2013

【 摘 要 】

Background

Deficits in the mismatch negativity (MMN) and P3a components are the most reliable and robust findings in schizophrenia. These abnormalities have also been recently documented in individuals clinically at risk for psychosis, indicating that the MMN may be a potential biomarker for psychosis. However, the at risk samples included in MMN studies are characterised by pre-existing clinical symptomatology and significant functional decline which are related to MMN amplitude. These factors may be potential confounds in determining whether deficient MMN is present prior to clinical manifestation of the disorder. Therefore, investigating the MMN in the extended psychosis phenotype comprising adolescents with psychotic symptoms from the general population may provide important information on whether abnormal MMN is apparent in the earliest stages of risk.

Methods

Thirty six adolescents completed a duration deviant MMN task. Fourteen adolescents with psychotic symptoms comprised the at risk group and 22 with no psychotic symptoms comprised the Controls. The task consisted of 85% standard tones (25 ms) and 15% deviant tones (50 ms). The groups were compared on MMN and P3a amplitude and latency across frontocentral and temporal electrodes.

Results

Adolescents with psychotic symptoms were characterised by a reduction in MMN amplitude at frontal and temporal regions compared to the controls.

Conclusions

This is the first study to demonstrate impaired auditory discrimination for duration deviant tones in nonclinical adolescents with psychotic symptoms. These findings suggest that MMN amplitude may be a possible biomarker for vulnerability to psychosis.

【 授权许可】

   
2013 Murphy et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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