期刊论文

【摘要】

Background

Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson’s disease, schizophrenia, depression, autism, and chronic fatigue syndrome.

Discussion

While the majority of patients with multiple sclerosis appear to have widespread mitochondrial dysfunction and impaired ATP production, the findings in patients diagnosed with Parkinson’s disease, autism, depression, bipolar disorder schizophrenia and chronic fatigue syndrome are less consistent, likely reflecting the fact that these diagnoses do not represent a disease with a unitary pathogenesis and pathophysiology. However, investigations have revealed the presence of chronic oxidative stress to be an almost invariant finding in study cohorts of patients afforded each diagnosis. This state is characterized by elevated reactive oxygen and nitrogen species and/or reduced levels of glutathione, and goes hand in hand with chronic systemic inflammation with elevated levels of pro-inflammatory cytokines.

Summary

This paper details mechanisms by which elevated levels of reactive oxygen and nitrogen species together with elevated pro-inflammatory cytokines could conspire to pave a major road to the development of mitochondrial dysfunction and impaired oxidative metabolism seen in many patients diagnosed with these disorders.

【授权许可】

2015 Berk and Morris; licensee BioMed Central.

【预览】

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【图表】

Figure 1.

Figure 2.

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BMC Medicine
The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

Michael Berk² Gerwyn Morris¹
[1]Tir Na Nog, Bryn Road seaside 87, Llanelli, Cardiff SA152LW, Wales, UK
[2]Department of Psychiatry, University of Melbourne, Level 1 North, Main Block, Royal Melbourne Hospital, Parkville 3052, Australia
关键词: Neurology; Psychiatry; Peroxynitrite; Parkinson’s disease; Oxidative stress; Nitric oxide; Multiple sclerosis; Mitochondrial dysfunction; Inflammatory; Immune dysfunction; Depression; Cytokines; Chronic fatigue syndrome; Schizophrenia; Bipolar disorder; Autism;
Others : 1160637 DOI : 10.1186/s12916-015-0310-y

received in 2014-12-23, accepted in 2015-03-04, 发布年份 2015
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