The Taiwan Birth Panel Study: a prospective cohort study for environmentally- related child health

BMC Research Notes

Pau-Chung Chen⁶  Yueliang Leon Guo¹  Chia-Yang Chen⁷  Kuen-Yuh Wu⁶  Yaw-Huei Hwang⁶  Feng-Ming Taso⁴  Suh-Fang Jeng²  Hua-Fang Liao²  Yi-Ning Su⁵  Wu-Shiun Hsieh³  Chia-Jung Hsieh⁶ 

[1] Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan;School and Graduate Institute of Physical Therapy, National Taiwan University College of Medicine, Taipei, Taiwan;Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan;Department of Psychology, National Taiwan University College of Science, Taipei, Taiwan;Department of Medical Genetics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan;Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan;Institute of Environmental Health, National Taiwan University College of Public Health, Taipei, Taiwan

关键词: single-nucleotide polymorphisms;    behaviour problem;    neurodevelopment;    child growth;    prenatal environmental exposure;    Cohort study;   

Others  :  1167291
DOI  :  10.1186/1756-0500-4-291

 received in 2011-04-13, accepted in 2011-08-12,  发布年份 2011

【 摘 要 】

Background

The Taiwan Birth Panel Study (TBPS) is a prospective follow-up study to investigate the development of child health and disease in relation to in-utero and/or early childhood environmental exposures. The rationale behind the establishment of such a cohort includes the magnitude of potential environmental exposures, the timing of exposure window, fatal and children's susceptibility to toxicants, early exposure delayed effects, and low-level or unknown neurodevelopmental toxicants.

Methods

A total of 486 mother-infant paired was enrolled from April 2004 to January 2005 in this study. Maternal blood before delivery, placenta and umbilical cord blood at birth, and mothers' urine after delivery were collected. The follow-up was scheduled at birth, 4, 6 months, and 1, 2, 3 and 5 years. The children's blood, urine, hair, and saliva were collected at 2 years of age and children's urine was collected at 5 years of age as well. The study has been approved by the ethical committee of National Taiwan University Hospital. All the subjects signed the inform consent on entering the study and each of the follow up.

Results

Through this prospective birth cohort, the main health outcomes were focused on child growth, neurodevelopment, behaviour problem and atopic diseases. We investigated the main prenatal and postnatal factors including smoking, heavy metals, perfluorinated chemicals, and non-persistent pesticides under the consideration of interaction of the environment and genes.

Conclusions

This cohort study bridges knowledge gaps and answers unsolved issues in the low-level, prenatal or postnatal, and multiple exposures, genetic effect modification, and the initiation and progression of "environmentally-related childhood diseases."

【 授权许可】

   
2011 Chen et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

【 参考文献 】

• [1]Woodruff TJ, Axelrad DA, Kyle AD, Nweke O, Miller GG, Hurley BJ: Trends in environmentally related childhood illnesses. Pediatrics 2004, 113(4 Suppl):1133-1140.
• [2]Barrett JR: On a growth curve: children's environmental health centers. Environ Health Perspect 2002, 110(10):A570-572.
• [3]Branum AM, Collman GW, Correa A, Keim SA, Kessel W, Kimmel CA, Klebanoff MA, Longnecker MP, Mendola P, Rigas M, et al.: The National Children's Study of environmental effects on child health and development. Environ Health Perspect 2003, 111(4):642-646.
• [4]Olsen J, Melbye M, Olsen SF, Sorensen TI, Aaby P, Andersen AM, Taxbol D, Hansen KD, Juhl M, Schow TB, et al.: The Danish National Birth Cohort--its background, structure and aim. Scand J Public Health 2001, 29(4):300-307.
• [5]Magnus P, Irgens LM, Haug K, Nystad W, Skjaerven R, Stoltenberg C: Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa). Int J Epidemiol 2006, 35(5):1146-1150.
• [6]Hiroshi N: World Research Trends in Child Health and the Environment. In SCIENCE & TECHNOLOGY TRENDS. Volume 32. Japan; 2009::34-42.
• [7]Susser E, Terry MB, Matte T: The birth cohorts grow up: new opportunities for epidemiology. Paediatr Perinat Epidemiol 2000, 14(2):98-100.
• [8]Eaton W: The logic for a conception-to-death cohort study. Ann Epidemiol 2002, 12(7):445-451.
• [9]Berkowitz GS, Wolff MS, Matte T, Susser E, Landrigan PJ: The rationale for a national prospective cohort study of environmental exposure and childhood development. Environ Res 2001, 85(2):59-68.
• [10]Grandjean P, Landrigan PJ: Developmental neurotoxicity of industrial chemicals. Lancet 2006, 368(9553):2167-2178.
• [11]Cadwell BM, Bradley RH: Home Observation for Measurement of the Environment. Little Rock, AR: University of Arkansas Press; 1979.
• [12]Morgan AM, Koch V, Lee V, Aldag J: Neonatal neurobehavioral examination. A new instrument for quantitative analysis of neonatal neurological status. Phys Ther 1988, 68(9):1352-1358.
• [13]Wang TM, Su CW, Liao HF, Lin LY, Chou KS, Lin SH: The standardization of the Comprehensive Developmental Inventory for Infants and Toddlers. Psychology Test 1998, 45:19-46.
• [14]Fenson L, Dale PS, Reznick JS: The MacArthur Communicative Development Inventories: User's Guide and Technical Manual. San Diego, CA: Singular Publishing Group; 1993.
• [15]Brown T, Lalor A: The Movement Assessment Battery for Children--Second Edition (MABC-2): a review and critique. Phys Occup Ther Pediatr 2009, 29(1):86-103.
• [16]Achenbach TM, Rescorla LA: Manual for the ASEBA preschool forms and profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, & Families; 2000.
• [17]Gau SS, Shang CY, Liu SK, Lin CH, Swanson JM, Liu YC, Tu CL: Psychometric properties of the Chinese version of the Swanson, Nolan, and Pelham, version IV scale - parent form. Int J Methods Psychiatr Res 2008, 17(1):35-44.
• [18]Fullard W, McDevitt SC, Carey WB: Assessing temperament in one- to three-year-old children. J Pediatr Psychol 1984, 9(2):205-217.
• [19]Tsou KS, Ju SH, Chen MY, Li SI, Hsu CC: A preliminary study of the temperamental characteristics of toddlers. Taiwanese Journal of Psychiatry 1987, 1:123-133.
• [20]Abidin RR: Parenting Stress Index: Professional Manual. 3rd edition. Odessa, FL: Psychological Assessment Resources; 1995.
• [21]Hsieh CJ, Liao HF, Wu KY, Hsieh WS, Su YN, Jeng SF, Yu SN, Chen PC: CYP1A1 Ile462Val and GSTT1 modify the effect of cord blood cotinine on neurodevelopment at 2 years of age. Neurotoxicology 2008, 29(5):839-845.
• [22]Hsieh CJ, Jeng SF, Su YN, Liao HF, Hsieh WS, Wu KY, Chen PC: CYP1A1 modifies the effect of maternal exposure to environmental tobacco smoke on child behavior. Nicotine Tob Res 2010, 12(11):1108-1117.
• [23]Wang IJ, Hsieh WS, Wu KY, Guo YL, Hwang YH, Jee SH, Chen PC: Effect of gestational smoke exposure on atopic dermatitis in the offspring. Pediatr Allergy Immunol 2008, 19(7):580-586.
• [24]Wang IJ, Guo YL, Lin TJ, Chen PC, Wu YN: GSTM1, GSTP1, prenatal smoke exposure, and atopic dermatitis. Ann Allergy Asthma Immunol 2010, 105(2):124-129.
• [25]Liu JH, Wu HC, Chen PC, Guo YL, Hwang YH: Concentration distributions of elements in umbilical cord blood in Taiwan. Taiwan Journal of Public Health 2009, 28(5):420-434.
• [26]Su FC, Liao HF, Hwang YH, Hsieh WS, Wu HC, Jeng SF, Su YN, Chen PC: In utero exposure to manganese and psychomotor development at the age of six months. Journal of Occupational Safety and Health 2007, 15:204-217.
• [27]Lin CM, Doyle P, Wang D, Hwang YH, Chen PC: The role of essential metals in the placental transfer of lead from mother to child. Reprod Toxicol 2010, 29(4):443-446.
• [28]Chuang CH, Liao HF, Hsieh WS, Jeng SF, Su YN, Chen PC: Maternal psychosocial factors around delivery on development of 2-year-old children: A prospective cohort study. J Paediatr Child Health 2010.
• [29]Chuang CH, Jeng SF, Hsieh WS, Liao HF, Su YN, Chen PC: Maternal psychosocial factors around delivery on behavior of two-year-old children: a prospective cohort study. Pediatrics International 2011.
• [30]Hu IJ, Chen PC, Su FC, Hsieh CJ, Jeng SF, Liao HF, Su YN, Lin SJ, Hsieh WS: Perinatal toxoplasmosis, northern Taiwan. Emerg Infect Dis 2006, 12(9):1460-1461.
• [31]Chen MH, Chen PC, Jeng SF, Hsieh CJ, Su FC, Liao HF, Su YN, Lin SJ, Hsieh WS: High perinatal seroprevalence of cytomegalovirus in northern Taiwan. J Paediatr Child Health 2008, 44(4):166-169.