Neutrophil gelatinase-associated lipocalin in dehydrated patients: a preliminary report

BMC Research Notes

Dimitrios N Rigopoulos¹  Theodoros N Sergentanis¹  Georgios Georgakopoulos¹  Alexandros Kalkanis¹  Constantine N Antonopoulos¹ 

[1] Department of Internal Medicine, 401 General Army Hospital, Athens, Greece

关键词: acute kidney injury;    biomarker;    Ngal;    Neutrophil Gelatinase-Associated Lipocalin;    dehydration;   

Others  :  1167045
DOI  :  10.1186/1756-0500-4-435

 received in 2011-03-12, accepted in 2011-10-22,  发布年份 2011

【 摘 要 】

Background

Acute kidney injury has been recognized as a major contributor to end stage renal disease. Although neutrophil gelatinase-associated lipocalin (Ngal) has been reported as a promising biomarker for early detection of acute kidney injury, no study has yet examined its potential clinical impact in patients with normal renal function. The purpose of current study is to investigate possible difference in serum Ngal levels between dehydrated and control patients.

Findings

A total of twelve patients presented with symptoms of mild dehydration defined by history of diarrheas or vomiting and orthostatic (postural) hypotension and an age and sex matched group of twelve control patients were included. The two groups of patients did not seem to differ in basic clinical and laboratory parameters. Serum Ngal was higher in dehydrated patients when compared to control group (Ngal = 129.4 ± 25.7 ng/mL vs 60.6 ± 0.4 ng/mL, p = 0.02). Ngal was not correlated with age, hemoglobin, white blood cell count, red blood cell count, urea or creatinine.

Conclusions

The presence of elevated Ngal levels in dehydrated patients may suggest its role as a very sensitive biomarker in even minimal and "silent" prerenal kidney dysfunction

【 授权许可】

   
2011 Antonopoulos et al; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Devarajan P: Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease. Scand J Clin Lab Invest Suppl 2008, 241:89-94.
• [2]Jo SK, Rosner MH, Okusa MD: Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizon. Clin J Am Soc Nephrol 2007, 2:356-365.
• [3]Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, et al.: Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005, 365:1231-1238.
• [4]Macedo E, Mehta RL: Prerenal failure: from old concepts to new paradigms. Curr Opin Crit Care 2009, 15:467-473.
• [5]Racusen LC, Prozialeck DH, Solez K: Glomerular epithelial cell changes after ischemia or dehydration. Possible role of angiotensin II. Am J Pathol 1984, 114:157-163.
• [6]Lauverjat M, Hadj Aissa A, Vanhems P, Bouletreau P, Fouque D, Chambrier C: Chronic dehydration may impair renal function in patients with chronic intestinal failure on long-term parenteral nutrition. Clin Nutr 2006, 25:75-81.