Congenital anomalies among live births in a polluted area. A ten-year retrospective study

BMC Pregnancy and Childbirth

Giuseppe Latini¹  Maria Grazia Andreassi³  Maria Angela Vigotti⁴  Carlo Leo⁵  Gabriella Padolecchia⁵  Roberto Guarino²  Saverio Sabina²  Enrico Rosati¹  Antonella Bruni²  Emilio Antonio Luca Gianicolo² 

[1] Division of Neonatology, Perrino Hospital, Brindisi, Italy;National Research Council, Institute of Clinical Physiology, Campus Ecotekne Building A7, Via per Monteroni, 73100, Lecce, Italy;National Research Council, Institute of Clinical Physiology, Pisa, Italy;University of Pisa, Pisa, Italy;Local Health Unit, Brindisi, Italy

关键词: Registers of congenital anomalies;    Surveillance of birth defects;    Hospital discharge data;    Congenital anomalies;   

Others  :  1151316
DOI  :  10.1186/1471-2393-12-165

 received in 2012-04-11, accepted in 2012-12-18,  发布年份 2012

【 摘 要 】

Background

Congenital anomalies and their primary prevention are a crucial public health issue. This work aimed to estimate the prevalence of congenital anomalies in Brindisi, a city in southeastern Italy at high risk of environmental crisis.

Methods

This research concerned newborns up to 28 days of age, born between 2001 and 2010 to mothers resident in Brindisi and discharged with a diagnosis of congenital anomaly. We classified cases according to the coding system adopted by the European Network for the Surveillance of Congenital Anomalies (EUROCAT). Prevalence rates of congenital anomalies in Brindisi were compared with those reported by EUROCAT. Logistic regression models were adapted to evaluate the association between congenital anomalies and municipality of residence of the mother during pregnancy.

Results

Out of 8,503 newborns we recorded 194 subjects with congenital anomalies (228.2/10,000 total births), 1.2 times higher than the one reported by the EUROCAT pool of registries. We observed 83 subjects with congenital heart diseases with an excess of 49.1%. Odds Ratios for congenital heart diseases significantly increased for newborns to mothers resident in Brindisi (OR 1.75 CI 95% 1.30-2.35).

Conclusions

Our findings indicated an increased prevalence of Congenital Anomalies (especially congenital heart diseases) in the city of Brindisi. More research is needed in order to analyze the role of factors potentially involved in the causation of congenital anomalies.

【 授权许可】

   
2012 Gianicolo et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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