Osteoarthritis and frailty in elderly individuals across six European countries: results from the European Project on OSteoArthritis (EPOSA)

BMC Musculoskeletal Disorders

Dorly Deeg³  Laura Schaap³  Richard Peter⁴  Mark Edwards⁵  Sabina Zambon²  Natasja van Schoor³  Rocio Queipo⁶  Mercedes Sanchez-Martinez⁶  Nancy Pedersen¹  Michael Denkinger⁴  Elaine Dennison⁵  Paola Siviero²  Angel Otero⁶  Suzan van der Pas³  Maria Victoria Castell⁶ 

[1] Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;Medicine and Surgical Sciences. Institute of Neuroscience, University of Padova, Padua, Italy;EMGO Institute for Health and Care Research, Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands;Bethesda Geriatric Clinic, University of Ulm, Ulm, Germany;MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK;IdiPAZ, Instituto de Investigacion de La PAZ, Madrid, Spain

关键词: Prevalence;    Frailty;    Osteoarthritis;    Older people;    European;   

Others  :  1233984
DOI  :  10.1186/s12891-015-0807-8

 received in 2014-09-15, accepted in 2015-11-06,  发布年份 2015

【 摘 要 】

Background

Osteoarthritis (OA) is the most common cause of disability in the elderly. Clinical frailty is associated with high mortality, but few studies have explored the relationship between OA and frailty.

The objective of this study was to consider the association between OA and frailty/pre-frailty in an elderly population comprised of six European cohorts participating in the EPOSA project.

Methods

Longitudinal study using baseline data and first follow-up waves, from EPOSA; 2,455 individuals aged 65-85 years were recruited from pre-existing population-based cohorts in Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom. Data were collected on clinical OA at any site (hand, knee or hip), based on the clinical classification criteria developed by the American College of Rheumatology (ACR). Frailty was defined according to Fried's criteria. The covariates considered were age, gender, educational level, obesity and country. We used multinomial logistic regression to analyse the associations between OA, frailty/pre-frailty and other covariates.

Results

The overall prevalence of clinical OA at any site was 30.4 % (95 % CI:28.6-32.2); frailty was present in 10.2 % (95 % CI:9.0-11.4) and pre-frailty in 51.0 % (95 % CI:49.0-53.0). The odds of frailty was 2.96 (95 % CI:2.11-4.16) and pre-frailty 1.54 (95 % CI:1.24-1.91) as high among OA individuals than those without OA. The association remained when Knee OA, hip OA or hand OA were considered separately, and was stronger in those with increasing number of joints.

Conclusions

Clinical OA is associated with frailty and pre-frailty in older adults in European countries. This association might be considered when designing appropriate intervention strategies for OA management.

【 授权许可】

   
2015 Castell et al.

【 图 表 】

Fig. 1.

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