Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese

BMC Genetics

Hongbing Shen⁴  Zhibin Hu⁴  Juncheng Dai²  Guangfu Jin²  Jianhang Gong²  Yuan Lin²  Jiangbo Du²  Yudi Lin¹  Meihua Dong¹  Huizhang Li³  Feng Lu⁵  Sijun Liu²  Yun Qian² 

[1] Department of Chronic Non-communicable Disease Control, Wuxi Center for Disease Control and Prevention, Wuxi, China;Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China;Department of Cancer Prevention and Treatment, Zhejiang Cancer Hospital, Hangzhou, China;State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China;Department of Chronic Non-communicable Disease Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China

关键词: Type 2 diabetes;    Single nucleotide polymorphism;    Genetic susceptibility;    Genome-wide association study;    Fat mass and obesity-associated Gene;   

Others  :  1086664
DOI  :  10.1186/1471-2156-14-86

 received in 2013-04-03, accepted in 2013-09-16,  发布年份 2013

【 摘 要 】

Background

Genome-wide association study (GWAS) has identified that rs8050136 C/A polymorphism in fat mass and obesity-associated gene (FTO) was associated with the risk of type 2 diabetes (T2D) in Europeans. But this association was abolished after adjustment for body mass index (BMI), suggesting that the effect of rs8050136 on T2D risk might be mediated by BMI in Europeans. However, the findings in subsequent studies were inconsistent among Asian populations. To determine whether rs8050136 polymorphism in FTO is independently associated with the risk of T2D in Chinese, we conducted a case–control study with 2,925 T2D patients and 3,281 controls in Han Chinese.

Results

Logistic regression revealed that the A allele of rs8050136 was significantly associated with an increased risk of T2D, independent of BMI (odds ratio (OR) = 1.17, 95% confidence interval (95% CI) = 1.03-1.32, p = 0.016). Meta-analysis containing 10 reported studies and our data with a total of 15,819 cases and 18,314 controls further confirmed the association between rs8050136 polymorphism and T2D risk in East Asians (OR = 1.13, 95% CI = 1.07-1.19).

Conclusions

Our findings indicate that the genetic variant in FTO may contribute to T2D risk in Han Chinese and rs8050136 polymorphism may be a genetic marker for T2D susceptibility.

【 授权许可】

   
2013 Qian et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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